Derleme

Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health

Cilt: 4 Sayı: 1 23 Mart 2023
PDF İndir
EN

Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health

Öz

5-Hydroxytryptophan (5-HTP) is an amino acid that the body synthesizes spontaneously. It is also known as the active metabolite of L-Tryptophan amino acid. L-Tryptophan participates in the production of serotonin in the body. The body uses 5-HTP to produce the chemical hormone serotonin, which sends signals to nerve cells. Low levels of serotonin are associated with susceptibility to depression, anxiety, sleep disorders, weight gain, and other health problems. In various clinical studies, 5-HTP has also been reported to treat fibromyalgia, myoclonus, migraine and cerebellar ataxia. Positive effects of 5-HTP have been observed in human and animal studies for neurodegenerative diseases such as Alzheimer's and Parkinson's. However, it has been proven in human clinical studies that it supports weight control by providing satiety and is effective on obesity treatment. 5-HTP supplements are thought to treat depression by increasing serotonin levels. In addition, studies show that the potential antidepressant effects of 5-HTP are stronger when combined with other substances or antidepressant drugs than when they are used alone. Increasing the production of serotonin in the body has several therapeutic effects. Therefore, 5-Hydroxytryptophan is effective in eliminating sleep disorders and improving sleep quality by increasing melatonin production. Nutritional supplements containing 5-Hydroxytryptophan are becoming increasingly popular, as it plays an important role in producing serotonin. Caution should be exercised when using it in combination with antidepressants or other interacting nutritional supplements. Some medications can increase serotonin production. Combining these drugs with 5-HTP can cause dangerous levels of serotonin in the body. Care should be taken when using 5-HTP nutritional support, and as with all other nutritional supplements, it should be used under doctor's control and daily dosages should be observed. Using the wrong dosage can lead to gastrointestinal system disorders such as diarrhea, vomiting, stomach pain. In addition, different dosages and usage times are recommended for different effects. However, these clinical findings, like all therapeutic findings for 5-HTP, are preliminary and need to be confirmed by further research.

Anahtar Kelimeler

Destekleyen Kurum

İstanbul Okan Üniversitesi

Kaynakça

  1. 1. Yang, T. H., Hsu, P. Y., Meng, M., & Su, C. C. (2015). Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis. Arthritis research & therapy, 17(1), 1-12.
  2. 2. Sharma, A., Castellani, R. J., Smith, M. A., Muresanu, D. F., Dey, P. K., & Sharma, H. S. (2019). 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology. In International Review of Neurobiology (Vol. 146, pp. 1-44). Academic Press.
  3. 3. Pappert, E. J., Goetz, C. G., Stebbins, G. T., Belden, M., & Carvey, P. M. (1998). 5-Hydroxytryptophan-induced myoclonus in guinea pigs: Mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology, 347(1), 51-56.
  4. 4. Zhao, F., Ma, C., Zhao, G., Wang, G., Li, X., & Yang, K. (2019). Rumen-protected 5-hydroxytryptophan improves sheep melatonin synthesis in the pineal gland and intestinal tract. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 25, 3605.
  5. 5. Weaver, S. R., Prichard, A. S., Maerz, N. L., Prichard, A. P., Endres, E. L., Hernández-Castellano, L. E., ... & Hernandez, L. L. (2017). Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation. PloS one, 12(9), e0184939.
  6. 6. Kious, B. M., Sabic, H., Sung, Y. H., Kondo, D. G., & Renshaw, P. (2017). An open-label pilot study of combined augmentation with creatine monohydrate and 5-hydroxytryptophan for SSRI-or SNRI-resistant depression in adult women. Journal of clinical psychopharmacology, 37(5), 578.
  7. 7. Coutinho, S. R., Rehfeld, J. F., Holst, J. J., Kulseng, B., & Martins, C. (2018). Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity. American Journal of Physiology-Endocrinology and Metabolism.
  8. 8. King, N. A., Caudwell, P. P., Hopkins, M., Stubbs, J. R., Naslund, E., & Blundell, J. E. (2009). Dual-process action of exercise on appetite control: Increase in orexigenic drive but improvement in meal-induced satiety. The American journal of clinical nutrition, 90(4), 921-927.

Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yayımlanma Tarihi

23 Mart 2023

Gönderilme Tarihi

9 Kasım 2022

Kabul Tarihi

3 Mart 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 4 Sayı: 1

Kaynak Göster

APA
Otrav, İ., & Günal, A. M. (2023). Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health. Journal of Innovative Healthcare Practices, 4(1), 1-8. https://izlik.org/JA86CY65DU
AMA
1.Otrav İ, Günal AM. Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health. Journal of Innovative Healthcare Practices. 2023;4(1):1-8. https://izlik.org/JA86CY65DU
Chicago
Otrav, İpek, ve Ahmet Murat Günal. 2023. “Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health”. Journal of Innovative Healthcare Practices 4 (1): 1-8. https://izlik.org/JA86CY65DU.
EndNote
Otrav İ, Günal AM (01 Mart 2023) Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health. Journal of Innovative Healthcare Practices 4 1 1–8.
IEEE
[1]İ. Otrav ve A. M. Günal, “Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health”, Journal of Innovative Healthcare Practices, c. 4, sy 1, ss. 1–8, Mar. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA86CY65DU
ISNAD
Otrav, İpek - Günal, Ahmet Murat. “Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health”. Journal of Innovative Healthcare Practices 4/1 (01 Mart 2023): 1-8. https://izlik.org/JA86CY65DU.
JAMA
1.Otrav İ, Günal AM. Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health. Journal of Innovative Healthcare Practices. 2023;4:1–8.
MLA
Otrav, İpek, ve Ahmet Murat Günal. “Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health”. Journal of Innovative Healthcare Practices, c. 4, sy 1, Mart 2023, ss. 1-8, https://izlik.org/JA86CY65DU.
Vancouver
1.İpek Otrav, Ahmet Murat Günal. Effects of 5-Hydroxytryptophan (5-Htp) Nutritional Supplement on Health. Journal of Innovative Healthcare Practices [Internet]. 01 Mart 2023;4(1):1-8. Erişim adresi: https://izlik.org/JA86CY65DU