Implant and Immunity in Neurosurgery

Yıl 2019, Cilt: 1 Sayı: 1, 31 - 34, 17.06.2019

Ceren Kızmazoğlu Hasan Emre Aydın Orhan Kalemci

Öz

Biological implants are widely used in neurosurgical operations especially in spine surgery. Many non-allergen metal implants have been developed such as titanium. Allergies agains other metal implants such as nickel, cobalt, and chrome, are common in the general population. Allergic reactions could cause complications such as intense pain, excessive inflammation, or rejection of implanted material/tissue. Implant life period depends on tissue implant reactions. Natural immunity and adaptive immune responses play a part in inflamatory reactions. Diagnostic tests could be done for metal implants allegy. In conclusion, if the titanium hypersensitivity reaction is proven, the definitive treatment is the removal of the device.

Anahtar Kelimeler

Allergy, implant, immunity

Nöroşirurjide İmplant ve İmmünite

Öz

Biyolojik implantlar, nöroşirürji operasyonları, özellikle omurga cerrahisinde yaygın olarak kullanılır. Titanyum gibi alerjik olmayan birçok metal implant geliştirilmiştir. Nikel, kobalt ve krom gibi diğer metal implantlara karşı alerjiler, genel popülasyonda yaygındır. Alerjik reaksiyonlar, şiddetli ağrı, aşırı iltihaplanma veya implant materyalin dokunun reddi gibi komplikasyonlara neden olabilir. İmplant ömrü, doku implantı reaksiyonlarına bağlıdır. Doğal bağışıklık ve adaptif bağışıklık tepkileri, enflamatuar reaksiyonlarda rol oynar. Metal implantları için tanı amaçlı testler yapılabilir. Sonuç olarak, eğer titanyum aşırı duyarlılık reaksiyonu kanıtlanmışsa kesin tedavi cihazın çıkarılmasıdır.

Anahtar Kelimeler

Alerji, implant, immünite

Kaynakça

• 1. Katou F, Andoh N, Motegi K, Nagura H. Immuno-inflammatory responses in the tissue adjacent to titanium miniplates used in the treatment of mandibular fractures. J Craniomaxillofac Surg. 1996;24(3):155-62.
• 2. Leopold SS, Berger RA, Patterson L, Skipor AK, Urban RM, Jacobs JJ. Serum titanium level for diagnosis of a failed, metal-backed patellar component. J Arthroplasty. 2000;15(7):938-43.
• 3. Purdue PE, Koulouvaris P, Potter HG, Nestor BJ, Sculco TP. The cellular and molecular biology of periprosthetic osteolysis. Clin Orthop Relat Res. 2007;454:251-61.
• 4. Revell PA. The combined role of wear particles, macrophages and lymphocytes in the loosening of total joint prostheses. J R Soc Interface. 2008;5(28):1263-78.
• 5. Abu-Amer Y, Darwech I, Clohisy JC. Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies. Arthritis Res Ther. 2007;9 Suppl 1:S6.
• 6. Mori G, D'Amelio P, Faccio R, Brunetti G. The Interplay between the bone and the immune system. Clin Dev Immunol. 2013;2013:720504.
• 7. al-Saffar N, Revell PA. Pathology of the bone-implant interfaces. J Long Term Eff Med Implants. 1999;9(4):319-47.
• 8. Revell PA, al-Saffar N, Kobayashi A. Biological reaction to debris in relation to joint prostheses. Proc Inst Mech Eng H. 1997;211(2):187-97.
• 9. Hercus B, Revell PA. Phenotypic characteristics of T lymphocytes in the interfacial tissue of aseptically loosened prosthetic joints. J Mater Sci Mater Med. 2001;12(10-12):1063-7.
• 10. Saeed S, Revell PA. Production and distribution of interleukin 15 and its receptors (IL-15Ralpha and IL-R2beta) in the implant interface tissues obtained during revision of failed total joint replacement. Int J Exp Pathol. 2001;82(3):201-9.
• 11. Bernard S, Baeck M, Tennstedt D, Haufroid V, Dekeuleneer V. Chromate or titanium allergy -- the role of impurities? Contact Dermatitis. 2013;68(3):191-2.
• 12. Cederbrant K, Hultman P, Marcusson JA, Tibbling L. In vitro lymphocyte proliferation as compared to patch test using gold, palladium and nickel. Int Arch Allergy Immunol. 1997;112(3):212-7.
• 13. Wood MM, Warshaw EM. Hypersensitivity reactions to titanium: diagnosis and management. Dermatitis. 2015;26(1):7-25.
• 14. Thyssen JP, Linneberg A, Menne T, Johansen JD. The epidemiology of contact allergy in the general population--prevalence and main findings. Contact Dermatitis. 2007;57(5):287-99.
• 15. Kzhyshkowska J, Gudima A, Riabov V, Dollinger C, Lavalle P, Vrana NE. Macrophage responses to implants: prospects for personalized medicine. J Leukoc Biol. 2015;98(6):953-62.
• 16. Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008;20(2):86-100.
• 17. Luttikhuizen DT, Harmsen MC, Van Luyn MJ. Cellular and molecular dynamics in the foreign body reaction. Tissue Eng. 2006;12(7):1955-70.
• 18. Williams DF. On the mechanisms of biocompatibility. Biomaterials. 2008;29(20):2941-53.
• 19. Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu Rev Immunol. 2012;30:459-89.
• 20. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159-75.
• 21. Nauseef WM, Borregaard N. Neutrophils at work. Nat Immunol. 2014;15(7):602-11.
• 22. Zdolsek J, Eaton JW, Tang L. Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans. J Transl Med. 2007;5:31.
• 23. Basko-Plluska JL, Thyssen JP, Schalock PC. Cutaneous and systemic hypersensitivity reactions to metallic implants. Dermatitis. 2011;22(2):65-79.
• 24. Hallab N. Metal sensitivity in patients with orthopedic implants. J Clin Rheumatol. 2001;7(4):215-8.
• 25. Cadosch D, Chan E, Gautschi OP, Filgueira L. Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening--current concepts. J Biomed Mater Res A. 2009;91(4):1252-62.
• 26. Bozzini B, Carlino P, D'Urzo L, Pepe V, Mele C, Venturo F. An electrochemical impedance investigation of the behaviour of anodically oxidised titanium in human plasma and cognate fluids, relevant to dental applications. J Mater Sci Mater Med. 2008;19(11):3443-53.
• 27. Urban RM, Jacobs JJ, Tomlinson MJ, Gavrilovic J, Black J, Peoc'h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J Bone Joint Surg Am. 2000;82(4):457-76.
• 28. Kumazawa R, Watari F, Takashi N, Tanimura Y, Uo M, Totsuka Y. Effects of Ti ions and particles on neutrophil function and morphology. Biomaterials. 2002;23(17):3757-64.
• 29. Cadosch D, Chan E, Gautschi OP, Meagher J, Zellweger R, Filgueira L. Titanium IV ions induced human osteoclast differentiation and enhanced bone resorption in vitro. J Biomed Mater Res A. 2009;91(1):29-36.