Effect of Teucrium polium L. plant on HepG2 cell line grown in Turkey

Abstract

Introduction: Some plants have been used for medicinal purpose for centuries. One of the most popular plant is Teucrium polium L. that is used by Persian and Southeastern Anatolia Region of Turkey for many pathological situations such as gastrointestinal disturbance, inflammation and diabetes. There are no study showing the level of toxicity of the Teucrium polium L. in the literature. The aim of this study is to investigate the effect of Teucrium polium L. Plant on HepG2 Cell Line Plant Grown in Turkey.
Material and Method: To measure of the toxicity levels Teucrium polium L. plant, cell culture method was used.
Results: According to the results, Teucrium polium L. plant has shown high level of toxicity on the HepG2 cell line.
Conclusion: According to our findings, unconsciously consumed products, even if they are natural, could be destroying in human body, or causing deaths and DNA breaking. Teucrium polium L. plant is not suitable for human use.

Keywords

• cytotoxicity
• hepG2
• Teucrium Polium L
• cell line
• toxicity

Türkiye’de yetişen Teucrium polium L. bitkisinin HepG2 hücre hattı üzerindeki etkisi

Abstract

Giriş: Bazı bitkiler yüzyıllardır tıbbi amaç için kullanılmaktadır. Gastrointestinal bozukluklar, inflamasyon ve diyabet gibi bazı patolojik durumlar için İranlılar ve Türkiye’nin Güneydoğu Anadolu Bölgesi tarafından kullanılan en popüler bitkilerden biri Teucrium polium L. ‘dir. Literatürde Teucrium polium L. bitkisinin toksisite seviyesini gösteren herhangi bir çalışma bulunmamaktadır. Bu çalışmada amaç; Türkiye’de yetişen Teucrium polium L. bitkisinin HepG2 hücre hattı üzerindeki etkisini araştırmaktır.
Gereç ve Yöntem: Çalışmamızda; Teucrium polium L. bitkisinin toksisite seviyesini ölçmek için hücre kültürü metodu kullanılmıştır.
Bulgular: Araştırmamızdan elde ettiğimiz sonuçlara göre; Teucrium polium L. bitkisi HepG2 hücre hattı üzerinde yüksek oranda toksisite göstermiştir.
Sonuç: Çalışmamızdan elde ettiğimiz bilgilere göre; insanların bilinçsizce tükettiği ürünler doğal da olsa, insan vücudunda tahribatlara, hücre ölümlerine, DNA kırıklarına neden olabilir. Teucrium polium L. bitkisi insanlar tarafından kullanıma uygun değildir.

Keywords

• HepG2
• Teucrium polium L.,
• toksisite
• sitotoksisite
• hücre hattı

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