Akut iskemik inme ve geçici iskemik atağın tanısında ortalama trombosit hacminin ölçümü

Yıl 2025, Cilt: 6 Sayı: 1, 7 - 12, 14.02.2025

Erkan Boğa

https://doi.org/10.47582/jompac.1590302

Öz

Özet

Amaç:
Bu çalışmanın temel amacı, ortalama trombosit hacminin (MPV) akut iskemik inme (AIS) ve geçici iskemik atağın (TIA) tanı ve prognostik değerlendirmesindeki potansiyel rolünü araştırmaktır. Çalışma, AIS ve TIA hastalarında MPV’nin klinik önemini değerlendirmeyi ve tanı süreçlerine katkısını incelemeyi hedeflemiştir.

Yöntemler:
Bu retrospektif çalışma, 15 Haziran - 15 Aralık 2014 tarihleri arasında Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Acil Tıp Kliniği’nde gerçekleştirilmiştir. Çalışmaya AIS veya TIA tanısı almış 300 hasta ile demografik olarak eşleştirilmiş 100 sağlıklı bireyden oluşan bir kontrol grubu dahil edilmiştir. Katılımcılar, hipertansiyon, diyabet ve hiperlipidemi gibi vasküler risk faktörlerine göre değerlendirilmiş ve AIS alt grupları TOAST sınıflamasına göre analiz edilmiştir. MPV ve trombosit sayıları ile birlikte biyokimyasal parametreler ölçülmüş ve istatistiksel analizler SPSS yazılımı kullanılarak gerçekleştirilmiştir.

Bulgular:
Olgu grubundaki MPV değerleri, kontrol grubuna kıyasla anlamlı derecede yüksek bulunmuştur (p<0.001). Trombosit sayıları açısından gruplar arasında anlamlı bir fark saptanmamıştır (p>0.05). MPV, hipertansiyon, hiperlipidemi ve diğer vasküler risk faktörleriyle anlamlı bir ilişki göstermemiştir; ancak TIA öyküsü olan hastalarda MPV’nin daha yüksek olduğu gözlenmiştir, bu fark istatistiksel olarak anlamlı değildir. MPV ile trombosit sayıları arasında zayıf, ancak istatistiksel olarak anlamlı bir negatif korelasyon tespit edilmiştir (r=-0.20, p<0.05).

Sonuç:
Ortalama trombosit hacmi, AIS ve TIA’nın tanı ve prognostik süreçlerinde önemli bir biyobelirteç olarak kullanılma potansiyeline sahiptir. Ancak, MPV ile risk faktörleri arasındaki ilişkiye dair literatürde gözlenen tutarsızlıklar, bu parametrenin klinik uygulamalardaki yerini netleştirmek için daha kapsamlı, prospektif ve standartlaştırılmış çalışmaları gerekli kılmaktadır. Bulgular, MPV’nin klinik uygulamalarda tanısal doğruluğun artırılmasına katkı sağlayabileceğini düşündürmektedir.

Anahtar Kelimeler:
Akut iskemik inme, geçici iskemik atak, ortalama trombosit hacmi, biyobelirteç, serebrovasküler hastalık.

Anahtar Kelimeler

Anahtar Kelimeler: Akut iskemik inme, geçici iskemik atak, ortalama trombosit hacmi, biyobelirteç, serebrovasküler hastalık.

Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack

Öz

Abstract
Aims: The primary aim of this study is to investigate the potential role of mean platelet volume (MPV) in the diagnostic and prognostic evaluation of acute ischemic stroke (AIS) and transient ischemic attack (TIA), focusing on its clinical significance and role in diagnostic processes. This study aims to evaluate the clinical significance of MPV in patients with AIS and TIA and its role in diagnostic processes.
Methods: This retrospective study was conducted between June 15 and December 15, 2014, at the Emergency Medicine Department of Haydarpaşa Numune Training and Research Hospital. The study included 300 patients diagnosed with AIS or TIA and 100 healthy individuals matched for demographic characteristics as the control group. Participants were evaluated based on vascular risk factors such as hypertension, diabetes, and hyperlipidemia, and AIS subgroups were analyzed according to the TOAST classification. MPV and platelet counts, along with biochemical parameters, were measured, and statistical analyses were performed utilizing SPSS software.
Results: MPV values in the case group were significantly higher compared to the control group (p<0.001). No significant differences were observed in platelet counts between the two groups (p>0.05). MPV demonstrated no significant associations with hypertension, hyperlipidemia, or other vascular risk factors; however, patients with a history of TIA exhibited higher MPV levels compared to those without, although the difference was not statistically significant. A weak but statistically significant negative correlation was identified between MPV and platelet counts (r=-0.20, p<0.05).
Conclusion: MPV demonstrates potential as a significant biomarker in the diagnostic and prognostic processes of AIS and TIA. Nevertheless, the inconsistencies observed in the literature regarding the relationship between MPV and risk factors necessitate more extensive, prospective, and standardized studies to elucidate its clinical utility. The evidence suggests that MPV may contribute to enhancing diagnostic accuracy in clinical practice.

Anahtar Kelimeler

Acute ischemic stroke, transient ischemic attack, mean platelet volume, biomarker, cerebrovascular disease

Kaynakça

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