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Total diz protezi hastalarında hızlandırılmış iyileşme protokolü: adduktor kanal bloğu ile ağrı ve opioid tüketiminin azaltılması

Yıl 2025, Cilt: 6 Sayı: 3, 252 - 257, 18.06.2025
https://doi.org/10.47582/jompac.1655139

Öz

Giriş
Bu çalışma, Enhanced Recovery After Surgery (ERAS) protokollerine uygun olarak gerçekleştirilen total diz artroplastisi (TKA) operasyonlarında ultrason eşliğinde uygulanan adduktör kanal bloğunun (AKB) ameliyat sonrası ağrı kontrolü, opiyat tüketimi ve taburculuk süresi üzerindeki etkilerini değerlendirmeyi amaçlamaktadır.

Yöntem
Bu prospektif gözlemsel kohort çalışma, Pamukkale Üniversitesi Hastanesi Anesteziyoloji ve Reanimasyon Yoğun Bakım Ünitesinde, Pamukkale Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulu’ndan alınan etik onay (08.01.2020-E.1710) ile yürütülmüştür. Birincil çıktı, ameliyat sonrası ilk 24 saat içinde istirahat hâlinde ve ilk ambulasyon sırasında ölçülen Visual Analog Skala (VAS) skorlarıydı. İkincil çıktılar arasında ameliyat sonrası tramadol kullanımı, dozu, opioide bağlı yan etkiler, ilk ambulasyon süresi, ambulasyon mesafesi, hasta memnuniyeti, 24. saatteki kuadriseps kas gücü ve taburculuğa hazır olma zamanı yer almaktadır. Veriler SPSS 25.0 yazılımı kullanılarak analiz edilmiştir. Sürekli değişkenler ortalama ± standart sapma, kategorik değişkenler ise sayı ve yüzde biçiminde ifade edilmiştir. Gruplar arası karşılaştırmalarda Independent T testi ve Mann-Whitney U testi, grup içi değişikliklerin değerlendirilmesinde Friedman testi uygulanmıştır. Kategorik veriler Pearson Ki-kare testiyle analiz edilmiştir. İstatistiksel anlamlılık düzeyi p<0.05 olarak kabul edilmiştir.

Bulgular
Çalışmaya TKA uygulanan 60 hasta dâhil edilmiştir. Hastalar iki gruba ayrılmıştır: Grup I yalnızca LIA almış, Grup II ise hem LIA hem de AKB (20 mL içinde 15 mL %0,5 bupivakain, 4 mL serum fizyolojik ve 1 mL epinefrin) almıştır. Ağrı, ilk 24 saat içinde istirahat hâlinde, yürüme sırasında ve VAS yöntemiyle ölçülmüştür. Grup II, istirahat, yürüme ve uyku dâhil tüm zaman noktalarında Grup I’e göre sürekli olarak daha düşük VAS skorlarına sahip olmuştur (p<0,05). Opioid tüketimi Grup I’de anlamlı derecede daha yüksek bulunmuştur (p<0,027) ve taburculuğa hazır olma süresi Grup I’de Grup II’ye kıyasla daha geç gerçekleşmiştir (p<0,05).

Sonuç
AKB alan hastalarda, ameliyat sonrasındaki ilk 24 saat boyunca istirahat, ambulasyon ve uyku esnasında ölçülen VAS skorlarının anlamlı derecede daha düşük olduğu görülmüştür. Ayrıca opioid tüketimi daha düşük, yan etki insidansı daha az, hasta memnuniyeti daha yüksek ve taburculuğa hazır olma süresi AKB grubunda daha kısa bulunmuştur.bölgesel anestezi.

Proje Numarası

Evrak Tarih ve Sayısı: 08.01.2020-E.1710

Kaynakça

  • ERAS Türkiye Derneği. ERAS Türkiye Derneği. http://eras.org.tr/page.php?id=9. Accessed October 15, 2020.
  • Wainwright TW, Gill M, McDonald DA, et al. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: enhanced recovery after surgery (ERAS) society recommendations. Acta Orthop. 2020;91(1):3-19. doi:10.1080/17453674. 2019.1683790
  • Pagnotto MR, Pagnano MW. Multimodal pain management with peripheral nerve blocks for total knee arthroplasty. Instr Course Lect. 2012;61:389-395.
  • Fraser TW, Doty JF. Peripheral nerve blocks in foot and ankle surgery. Orthop Clin North Am. 2017;48(4):507-515. doi:10.1016/j.ocl.2017.06.008
  • Cullom C, Weed JT. Anesthetic and analgesic management for outpatient knee arthroplasty. Curr Pain Headache Rep. 2017;21(5):23. doi:10.1007/s11916-017-0623-y
  • Li J, Lam D, King H, et al. Novel regional anesthesia for outpatient surgery. Curr Pain Headache Rep. 2019;23(10):69. doi:10.1007/s11916-019-0809-6
  • Kastelik J, Fuchs M, Krämer M, et al. Local infiltration anesthesia versus sciatic nerve and adductor canal block for fast-track knee arthroplasty: a randomized controlled clinical trial. Eur J Anaesthesiol. 2019;36(4):255-263. doi:10.1097/EJA.0000000000000929
  • Deiter J, Ponzio D, Grau L, et al. Efficacy of adductor canal block protocol implementation in a multimodal pain management protocol for total knee arthroplasty. J Clin Orthop Trauma. 2020;11(1):118-121. doi:10.1016/j.jcot.2019.05.012
  • Agarwala S, Bhadiyadra R, Menon A. Analgesic effectiveness of local infiltrative analgesia alone versus combined single-dose adductor canal block with local infiltrative analgesia: a single center case-control study. J Clin Orthop Trauma. 2020;11(Suppl 5):S717-S721. doi:10.1016/j.jcot. 2020.05.044
  • Çardaközü T, Aksu C. Abdominal cerrahide anestezi. KOU Sag Bil Derg. 2019;5(1):47-53. doi:10.30934/kusbed.456408
  • Frassanito L, Vergari A, Nestorini R, et al. Enhanced recovery after surgery (ERAS) in hip and knee replacement surgery: description of a multidisciplinary program to improve management of the patients undergoing major orthopedic surgery. Musculoskelet Surg. 2020;104(1): 87-92. doi:10.1007/s12306-019-00603-4
  • Goytizolo EA, Lin Y, Kim DH, et al. Addition of adductor canal block to periarticular injection for total knee replacement: a randomized trial. J Bone Joint Surg Am. 2019;101(9):812-820. doi:10.2106/JBJS.18.00195
  • Sawhney M, Mehdian H, Kashin B, et al. Pain after unilateral total knee arthroplasty: a prospective randomized controlled trial examining the analgesic effectiveness of a combined adductor canal peripheral nerve block with periarticular infiltration versus adductor canal nerve block alone versus periarticular infiltration alone. Anesth Analg. 2016;122(6): 2040-2046. doi:10.1213/ANE.0000000000001210
  • Henshaw DS, Jaffe JD, Reynolds JW, et al. An evaluation of ultrasound-guided adductor canal blockade for postoperative analgesia after medial unicondylar knee arthroplasty. Anesth Analg. 2016;122(4):1192-1201. doi:10.1213/ANE.0000000000001162
  • Lee HH, Kwon H, Lee WS, et al. Effectiveness of ERAS (enhanced recovery after surgery) protocol via peripheral nerve block for total knee arthroplasty. J Clin Med. 2022;11(12):3354. doi:10.3390/jcm11123354
  • Mingdeng X, Yuzhang A, Xiaoxiao X, et al. Combined application of adductor canal block and local infiltration anesthesia in primary total knee arthroplasty: an updated meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg. 2022;142(6):913-926. doi:10.1007/s00402-020-03706-x
  • Hussain N, Brull R, Zhou S, et al. Analgesic benefits of single-shot versus continuous adductor canal block for total knee arthroplasty: a systematic review and meta-analysis of randomized trials. Reg Anesth Pain Med. 2022;48(1):49-60. doi:10.1136/rapm-2022-103756
  • Gudmundsdottir S, Franklin JL. Continuous adductor canal block added to local infiltration analgesia (LIA) after total knee arthroplasty has no additional benefits on pain and ambulation on postoperative days 1 and 2 compared with LIA alone. Acta Orthop. 2017;88(5):537-542. doi:10.1080/17453674.2017.1342184
  • Laoruengthana A, Rattanaprichavej P, Kositanurit I, et al. Adductor canal block combined with interspace between the popliteal artery and capsule of the knee (iPACK) versus periarticular injection for total knee arthroplasty. Clin Orthop Surg. 2022;14(4):514-521. doi:10.4055/cios21108
  • Ahmed RKA, Mohamed AS, Nassef JN, et al. Adductor canal block as an adjuvant in a multimodal analgesia protocol vs. multimodal analgesia alone for total knee arthroplasty. Anaesth Pain Intensive Care. 2023; 27(1):31-36. doi:10.35975/apic.v27i1.1941
  • Muñoz-Leyva F, Jack JM, Bhatia A, et al. No benefits of adding dexmedetomidine, ketamine, dexamethasone, and nerve blocks to an established multimodal analgesic regimen after total knee arthroplasty. Anesthesiology. 2022;137(4):459-470. doi:10.1097/ALN. 0000000000004326
  • Xing Q, Dai W, Zhao D, et al. Adductor canal block with local infiltrative analgesia compared with local infiltrate analgesia for pain control after total knee arthroplasty: a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2017;96(38):e8103. doi:10.1097/MD.0000000000008103
  • Hanson NA, Derby RE, Auyong DB, et al. Ultrasound-guided adductor canal block for arthroscopic medial meniscectomy: a randomized, double-masked trial. Can J Anaesth. 2013;60(9):874-880. doi:10.1007/s12630-013-9992-9
  • Zhou M, Ding H, Ke J, et al. Adductor canal block in combination with posterior capsular infiltration on the pain control after TKA. Ir J Med Sci. 2018;187(2):465-471. doi:10.1007/s11845-017-1647-3
  • Li Y, Li A, Zhang Y, et al. The efficacy of combined adductor canal block with local infiltration analgesia for pain control after total knee arthroplasty: a meta-analysis. Medicine (Baltimore). 2018;97(49):e13326. doi:10.1097/MD.0000000000013326
  • Choi J, Lahori A, Merlo JA, et al. Adductor canal blocks with bupivacaine and magnesium after same-day discharge total knee arthroplasty improve postoperative pain relief and decrease opioid consumption. Clin J Pain. 2022;38(5):388-395. doi:10.1097/AJP.0000000000001036
  • Ahmad MR, Datu MD, Hardiyanti R, et al. Adductor canal block (ACB) provides adequate postoperative analgesia in patients undergoing total knee arthroplasty (TKA): case report. Open Pain J. 2022;15(1). doi:10. 2174/18763863-v15-e2206100
  • Ma J, Gao F, Sun W, et al. Combined adductor canal block with periarticular infiltration versus periarticular infiltration for analgesia after total knee arthroplasty. Medicine (Baltimore). 2016;95(52):e5701. doi:10.1097/MD.0000000000005701
  • Biswas A, Perlas A, Ghosh M, et al. Relative contributions of adductor canal block and intrathecal morphine to analgesia and functional recovery after total knee arthroplasty: a randomized controlled trial. Reg Anesth Pain Med. 2018;43(2):154-160. doi:10.1097/AAP. 0000000000000724
  • Perlas A, Kirkham KR, Billing R, et al. The impact of analgesic modality on early ambulation following total knee arthroplasty. Reg Anesth Pain Med. 2013;38(4):334-339. doi:10.1097/AAP.0b013e318296b6a0
  • Abdo HMA, Abd elaziz M, Eldin Abd Elhamid AE, et al. Effect of adding infiltration between the popliteal artery and capsule of the knee block (IPACK) to continuous adductor canal block after total knee arthroplasty. Egypt J Anaesth. 2023;39(3):680-686. doi:10.1080/11101849. 2023.2246732
  • Domagalska M, Reysner T, Kowalski G, et al. Pain management, functional recovery, and stress response expressed by NLR and PLR after the iPACK block combined with adductor canal block for total knee arthroplasty: a prospective, randomised, double-blinded clinical trial. J Clin Med. 2023;12(22):7088. doi:10.3390/jcm12227088
  • Kampitak W, Tanavalee A, Ngarmukos S, et al. Does adductor canal block have a synergistic effect on local infiltration analgesia for enhancing ambulation and improving analgesia after total knee arthroplasty? Knee Surg Relat Res. 2018;30(2):133-141. doi:10.5792/ksrr.17.088
  • Grevstad U, Mathiesen O, Valentiner LS, et al. Effect of adductor canal block versus femoral nerve block on quadriceps strength, mobilization, and pain after total knee arthroplasty: a randomized, masked study. Reg Anesth Pain Med. 2015;40(1):3-10. doi:10.1097/AAP.0000000000000169

Accelerated recovery protocol in total knee replacement patients: reducing pain and opioid consumption with adductor canal block

Yıl 2025, Cilt: 6 Sayı: 3, 252 - 257, 18.06.2025
https://doi.org/10.47582/jompac.1655139

Öz

Aims: This study aims to evaluate the effects of ultrasound-guided adductor canal block (ACB) on postoperative pain control, opioid consumption, and discharge time in total knee arthroplasty (TKA) operations performed in accordance with enhanced recovery after surgery (ERAS) protocols.
Methods: This prospective randomized controlled trial was conducted at Pamukkale University Hospital after obtaining ethical approval. A total of 60 patients who underwent TKA under spinal anesthesia were randomly assigned into two groups. Group I received only local infiltration analgesia (LIA), while group II received both LIA and an ACB. The groups were compared in terms of postoperative Visual Analog Scale (VAS) score at rest and during first ambulation, comparison of tramadol use, dosage, and side effects, time to first ambulation, ambulation distance, quadriceps muscle strength scores, and patient satisfaction and hospital discharge times.
Results: Group II showed consistently lower VAS scores compared with group I at all time points, including rest, walking, and sleep (p<0.05). Opioid consumption was significantly higher in group I (p=0.027), and readiness for discharge was delayed in group I compared with group II (p<0.05).
Conclusion: In patients undergoing TKA, the combination of LIA and ACB appears to be an effective option in multimodal analgesia practices during the postoperative period and may provide potential benefits in accelerating recovery and reducing opioid-related side effects.

Etik Beyan

Statements and Declarations Funding There were no external funding sources for this research. Conflict of Interest The authors declare that they have no conflict of interest. EthicalApproval It was approved by the Pamukkale University Ethics Committee (08.01.2020-E.1710). Acknowledgments None.

Destekleyen Kurum

Pamukkale University

Proje Numarası

Evrak Tarih ve Sayısı: 08.01.2020-E.1710

Teşekkür

None

Kaynakça

  • ERAS Türkiye Derneği. ERAS Türkiye Derneği. http://eras.org.tr/page.php?id=9. Accessed October 15, 2020.
  • Wainwright TW, Gill M, McDonald DA, et al. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: enhanced recovery after surgery (ERAS) society recommendations. Acta Orthop. 2020;91(1):3-19. doi:10.1080/17453674. 2019.1683790
  • Pagnotto MR, Pagnano MW. Multimodal pain management with peripheral nerve blocks for total knee arthroplasty. Instr Course Lect. 2012;61:389-395.
  • Fraser TW, Doty JF. Peripheral nerve blocks in foot and ankle surgery. Orthop Clin North Am. 2017;48(4):507-515. doi:10.1016/j.ocl.2017.06.008
  • Cullom C, Weed JT. Anesthetic and analgesic management for outpatient knee arthroplasty. Curr Pain Headache Rep. 2017;21(5):23. doi:10.1007/s11916-017-0623-y
  • Li J, Lam D, King H, et al. Novel regional anesthesia for outpatient surgery. Curr Pain Headache Rep. 2019;23(10):69. doi:10.1007/s11916-019-0809-6
  • Kastelik J, Fuchs M, Krämer M, et al. Local infiltration anesthesia versus sciatic nerve and adductor canal block for fast-track knee arthroplasty: a randomized controlled clinical trial. Eur J Anaesthesiol. 2019;36(4):255-263. doi:10.1097/EJA.0000000000000929
  • Deiter J, Ponzio D, Grau L, et al. Efficacy of adductor canal block protocol implementation in a multimodal pain management protocol for total knee arthroplasty. J Clin Orthop Trauma. 2020;11(1):118-121. doi:10.1016/j.jcot.2019.05.012
  • Agarwala S, Bhadiyadra R, Menon A. Analgesic effectiveness of local infiltrative analgesia alone versus combined single-dose adductor canal block with local infiltrative analgesia: a single center case-control study. J Clin Orthop Trauma. 2020;11(Suppl 5):S717-S721. doi:10.1016/j.jcot. 2020.05.044
  • Çardaközü T, Aksu C. Abdominal cerrahide anestezi. KOU Sag Bil Derg. 2019;5(1):47-53. doi:10.30934/kusbed.456408
  • Frassanito L, Vergari A, Nestorini R, et al. Enhanced recovery after surgery (ERAS) in hip and knee replacement surgery: description of a multidisciplinary program to improve management of the patients undergoing major orthopedic surgery. Musculoskelet Surg. 2020;104(1): 87-92. doi:10.1007/s12306-019-00603-4
  • Goytizolo EA, Lin Y, Kim DH, et al. Addition of adductor canal block to periarticular injection for total knee replacement: a randomized trial. J Bone Joint Surg Am. 2019;101(9):812-820. doi:10.2106/JBJS.18.00195
  • Sawhney M, Mehdian H, Kashin B, et al. Pain after unilateral total knee arthroplasty: a prospective randomized controlled trial examining the analgesic effectiveness of a combined adductor canal peripheral nerve block with periarticular infiltration versus adductor canal nerve block alone versus periarticular infiltration alone. Anesth Analg. 2016;122(6): 2040-2046. doi:10.1213/ANE.0000000000001210
  • Henshaw DS, Jaffe JD, Reynolds JW, et al. An evaluation of ultrasound-guided adductor canal blockade for postoperative analgesia after medial unicondylar knee arthroplasty. Anesth Analg. 2016;122(4):1192-1201. doi:10.1213/ANE.0000000000001162
  • Lee HH, Kwon H, Lee WS, et al. Effectiveness of ERAS (enhanced recovery after surgery) protocol via peripheral nerve block for total knee arthroplasty. J Clin Med. 2022;11(12):3354. doi:10.3390/jcm11123354
  • Mingdeng X, Yuzhang A, Xiaoxiao X, et al. Combined application of adductor canal block and local infiltration anesthesia in primary total knee arthroplasty: an updated meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg. 2022;142(6):913-926. doi:10.1007/s00402-020-03706-x
  • Hussain N, Brull R, Zhou S, et al. Analgesic benefits of single-shot versus continuous adductor canal block for total knee arthroplasty: a systematic review and meta-analysis of randomized trials. Reg Anesth Pain Med. 2022;48(1):49-60. doi:10.1136/rapm-2022-103756
  • Gudmundsdottir S, Franklin JL. Continuous adductor canal block added to local infiltration analgesia (LIA) after total knee arthroplasty has no additional benefits on pain and ambulation on postoperative days 1 and 2 compared with LIA alone. Acta Orthop. 2017;88(5):537-542. doi:10.1080/17453674.2017.1342184
  • Laoruengthana A, Rattanaprichavej P, Kositanurit I, et al. Adductor canal block combined with interspace between the popliteal artery and capsule of the knee (iPACK) versus periarticular injection for total knee arthroplasty. Clin Orthop Surg. 2022;14(4):514-521. doi:10.4055/cios21108
  • Ahmed RKA, Mohamed AS, Nassef JN, et al. Adductor canal block as an adjuvant in a multimodal analgesia protocol vs. multimodal analgesia alone for total knee arthroplasty. Anaesth Pain Intensive Care. 2023; 27(1):31-36. doi:10.35975/apic.v27i1.1941
  • Muñoz-Leyva F, Jack JM, Bhatia A, et al. No benefits of adding dexmedetomidine, ketamine, dexamethasone, and nerve blocks to an established multimodal analgesic regimen after total knee arthroplasty. Anesthesiology. 2022;137(4):459-470. doi:10.1097/ALN. 0000000000004326
  • Xing Q, Dai W, Zhao D, et al. Adductor canal block with local infiltrative analgesia compared with local infiltrate analgesia for pain control after total knee arthroplasty: a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2017;96(38):e8103. doi:10.1097/MD.0000000000008103
  • Hanson NA, Derby RE, Auyong DB, et al. Ultrasound-guided adductor canal block for arthroscopic medial meniscectomy: a randomized, double-masked trial. Can J Anaesth. 2013;60(9):874-880. doi:10.1007/s12630-013-9992-9
  • Zhou M, Ding H, Ke J, et al. Adductor canal block in combination with posterior capsular infiltration on the pain control after TKA. Ir J Med Sci. 2018;187(2):465-471. doi:10.1007/s11845-017-1647-3
  • Li Y, Li A, Zhang Y, et al. The efficacy of combined adductor canal block with local infiltration analgesia for pain control after total knee arthroplasty: a meta-analysis. Medicine (Baltimore). 2018;97(49):e13326. doi:10.1097/MD.0000000000013326
  • Choi J, Lahori A, Merlo JA, et al. Adductor canal blocks with bupivacaine and magnesium after same-day discharge total knee arthroplasty improve postoperative pain relief and decrease opioid consumption. Clin J Pain. 2022;38(5):388-395. doi:10.1097/AJP.0000000000001036
  • Ahmad MR, Datu MD, Hardiyanti R, et al. Adductor canal block (ACB) provides adequate postoperative analgesia in patients undergoing total knee arthroplasty (TKA): case report. Open Pain J. 2022;15(1). doi:10. 2174/18763863-v15-e2206100
  • Ma J, Gao F, Sun W, et al. Combined adductor canal block with periarticular infiltration versus periarticular infiltration for analgesia after total knee arthroplasty. Medicine (Baltimore). 2016;95(52):e5701. doi:10.1097/MD.0000000000005701
  • Biswas A, Perlas A, Ghosh M, et al. Relative contributions of adductor canal block and intrathecal morphine to analgesia and functional recovery after total knee arthroplasty: a randomized controlled trial. Reg Anesth Pain Med. 2018;43(2):154-160. doi:10.1097/AAP. 0000000000000724
  • Perlas A, Kirkham KR, Billing R, et al. The impact of analgesic modality on early ambulation following total knee arthroplasty. Reg Anesth Pain Med. 2013;38(4):334-339. doi:10.1097/AAP.0b013e318296b6a0
  • Abdo HMA, Abd elaziz M, Eldin Abd Elhamid AE, et al. Effect of adding infiltration between the popliteal artery and capsule of the knee block (IPACK) to continuous adductor canal block after total knee arthroplasty. Egypt J Anaesth. 2023;39(3):680-686. doi:10.1080/11101849. 2023.2246732
  • Domagalska M, Reysner T, Kowalski G, et al. Pain management, functional recovery, and stress response expressed by NLR and PLR after the iPACK block combined with adductor canal block for total knee arthroplasty: a prospective, randomised, double-blinded clinical trial. J Clin Med. 2023;12(22):7088. doi:10.3390/jcm12227088
  • Kampitak W, Tanavalee A, Ngarmukos S, et al. Does adductor canal block have a synergistic effect on local infiltration analgesia for enhancing ambulation and improving analgesia after total knee arthroplasty? Knee Surg Relat Res. 2018;30(2):133-141. doi:10.5792/ksrr.17.088
  • Grevstad U, Mathiesen O, Valentiner LS, et al. Effect of adductor canal block versus femoral nerve block on quadriceps strength, mobilization, and pain after total knee arthroplasty: a randomized, masked study. Reg Anesth Pain Med. 2015;40(1):3-10. doi:10.1097/AAP.0000000000000169
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Anesteziyoloji
Bölüm Research Articles [en] Araştırma Makaleleri [tr]
Yazarlar

Ayşe Tuğçe Evran 0009-0003-8538-353X

Turan Evran 0000-0003-4768-3622

Rıza Hakan Erbay 0000-0003-0609-0580

Proje Numarası Evrak Tarih ve Sayısı: 08.01.2020-E.1710
Yayımlanma Tarihi 18 Haziran 2025
Gönderilme Tarihi 10 Mart 2025
Kabul Tarihi 27 Mayıs 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 6 Sayı: 3

Kaynak Göster

AMA Evran AT, Evran T, Erbay RH. Accelerated recovery protocol in total knee replacement patients: reducing pain and opioid consumption with adductor canal block. J Med Palliat Care / JOMPAC / Jompac. Haziran 2025;6(3):252-257. doi:10.47582/jompac.1655139

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