Nonarteritik Anterior İskemik Optik Nöropatili Bireylerde Serebellum ve Kortikal Görme Merkezlerinin Otomatik Segmentasyon Kullanılarak Volümetrik İncelenmesi

Öz

Amaç: Non-arteritik anterior iskemik optik nöropati (NAİON), optik sinirin ön kısmındaki akut iskemik hasarın neden olduğu klinik bir durumdur. Bu çalışmada, NAİON hastalarının ve sağlıklı kontrollerin (HC) beyin manyetik rezonans görüntüleme (MRG) görüntüleri otomatik segmentasyon yöntemi kullanılarak analiz edildi ve karşılaştırıldı. Gereç ve Yöntem: Çalışmaya 14 NAİON ve 14 HC tanılı hasta dahil edildi. Beyin MR görüntülerinin volumetrik analizi için Voksel Tabanlı Morfometri (VBM) ile beyin parselasyonu sağlayan VolBrain yöntemi kullanıldı. Bulguların istatistiksel analizinde Mann-Whitney U testi kullanıldı. Bulgular: NAİON hastalarında cerebrum, substantia grisea ve substantia alba, lobus frontalis ve gyrus frontalis medius, lobus occipitalis, cortex calcarinus, gyrus lingualis, gyrus occipitalis superior ve gyrus occipitalis medius hacimlerinin HC’ye göre anlamlı derecede düşük olduğunu bulduk (p < 0,05). Cerebellum ve bölümlerinin hacim analizinde iki grup arasında istatistiksel olarak anlamlı bir fark yoktu (p > 0,05). Sonuç: Çalışmamız NAİON’un cortex cerebri’nin görsel ve görsel olmayan bölgelerinde hacimsel değişikliklere yol açtığını, ancak serebellum hacminde anlamlı bir değişiklik oluşturmadığını ortaya koymaktadır.

Anahtar Kelimeler

• Optik nöropati
• MRG
• Hacim
• Serebellum
• Serebral korteks

Volumetric examination of the cerebellum and cortical visual centres in individuals with nonarteritic anterior ischemic optic neuropathy using automatic segmentation

Öz

Objective: Non-arteritic anterior ischemic optic neuropathy (NAION) is a clinical condition caused by acute ischemic damage to the anterior part of the optic nerve. In this study, brain magnetic resonance imaging (MRI) images of NAION patients and healthy control subjects (HC) were analyzed and compared using an automatic segmentation method. Materials and Methods: The study included 14 patients diagnosed with NAION and 14 HC. VolBrain method, which provides brain parcellation with Voxel-Based Morphometry (VBM), was used for volumetric analysis of brain MR images. In the statistical analysis of the findings, the Mann-Whitney U test was employed. Results: We found that cerebrum, gray and white matter, frontal lobe and middle frontal gyri, occipital lobe, calcarine cortex, lingual gyrus, superior and middle occipital gyri volumes were significantly lower in NAION patients compared to the HC (p < 0.05). There was no statistically significant difference between the two groups in the volume analysis of the cerebellum and its parts (p > 0.05). Conclusions: Our study reveals that NAION induces volumetric changes in visual and non-visual regions of the cerebral cortex, but not in the volume of the cerebellum.

Anahtar Kelimeler

• Optic neuropathy
• MRI
• Volume
• Cerebellum
• Cerebral cortex

Etik Beyan

The necessary permission to conduct the research was obtained from Tokat Gaziosmanpaşa University Faculty of Medicine Dean's Office Clinical Research Ethics Committee (Date: 09.11.2023 No: 2023/20)

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