DNA Base Bioisosteres, Bis-benzoxazoles, Exert Anti-proliferative Effect on Human Prostate and Breast Cancer Cells

Yıl 2018, Cilt: 5 Sayı: 3, 1145 - 1152, 01.09.2018

Furkan Ayaz , Rusmeenee Kheeree Qadar Ahmed Isse Ronak Haj Ersan Oztekin Algul

https://doi.org/10.18596/jotcsa.429504

Cited By: 9

Öz

A series of symmetric bis-benzoxazole
derivatives were synthesized using one-pot cyclisation reaction between 4-chloro
substituted 2-aminophenol and suitable dicarboxylic acids. Synthesized
compounds’ anticancer activities were tested by using MTT assay on human prostate
(DU145) and breast (MCF7) cancer cells. Screening results revealed that all
compounds possessed a high level anti-cancer potential by significantly
decreasing the cell proliferation in prostate and breast cancer cell lines. Our
compounds exerted their anti-proliferative effects in a dose and time dependent
manner. Our results suggest that they can be highly potent since they were biologically
active even at low concentrations. Our study presents a series of new
bis-benzoxazole based compounds with potential therapeutic effects against tumor
cells. Therefore, characterization of new
generation bis-benzoxazole derivatives will have a significant contribution on the
development of new era anti-cancer drug candidates.   

Anahtar Kelimeler

Bis-benzoxazole, breast cancer, prostate cancer, anti-proliferative, anti-cancer, MTT

Kaynakça

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