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THE EFFECT OF BLACK ELDERBERRY ON THE IMMUNE SYSTEM

Yıl 2023, , 11 - 26, 29.04.2023

Başak Öney , Zehra Başer

https://doi.org/10.47115/jshs.1084660

Öz

Black elderberry, with its Latin name Sambucus nigra, is a plant belonging to
the Adoxaceae family that has been used for many years. Among their common
names are also black elderberry, black elder, European elder, European elderberry,
and European black elderberry. It is also known to be seen as the most healing
plant of nature by Hippocrates. Its fruits are dark purple-black in color. 100
grams contains an average of 73 calories and It has a very rich structure in terms
of vitamins and minerals. Black elderberry contains many useful compounds in
its structure. Among them, the most important are flavonoids, phenolic acids and
anth decyanins. The most dominant are anthocyanins, which are known to have
antioxidant properties. In addition, black elderberry can cause poisoning due to
the cyanogenic glycosides it contains. In order to prevent this, it must be consumed
after being exposed to heat treatment. Black elderberry is known to have various
effects such as diuretic, laxative, diaphoretic, antioxidant, antiviral, immunomodulatory,
anti-inflammatory, antimicrobial, anticonvulsant, antidepressant and
anticarcinogenic. It can also be used on diabetes, hypertension, obesity, hyperlipidemia,
metabolic dysfunctions, urinary parameters. It is known to strengthen the
immune system by supporting the regulation of the body’s defense mechanisms in
both healthy and sick organisms. Although studies are still insufficient, it is thought
that it can also be used for COVID-19. In this review, antioxidant, antiviral, antibacterial,
anti-inflammatory, anticancer effects and immune system relationship
of black elderberry are mentioned.

Anahtar Kelimeler

Elderberry; Sambucus Nigra Immune System Elderberry and İmmunity Antiviral COVID-19

Kaynakça

  • Aguzzi, C., Marinelli, O., Zeppa, L., Santoni, G., Maggi, F., & Nabissi, M. (2020). Evaluation of anti-inflammatory and immunoregulatory activities of Stimunex® and Stimunex D3® in human monocytes/macrophages stimu¬lated with LPS or IL-4/IL-13. Biomedicine & Pharmacotherapy, 132, 110845. https://doi.org/10.1016/j.biopha.2020.110845
  • Ağalar, H. G. (2019). Elderberry (Sambucus nigra L.). Seyed Mohammad Nabavi, Ana Sanches Silva (Ed.), Nonvitamin and Nonmineral Nutritional Supplements içinde (s. 211-215). Academic Press. https://doi.org/10.1016/B978- 0-12-812491-8.00030-8
  • Alıç, B., Olcay, N., & Demir, M. K. (2021). Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellik¬leri. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 11(2), 1140-1153.
  • Anton, A. M., Pintea, A. M., Rugină, D. O., Sconţa, Z. M., Hanganu, D., Vlase, L., & Benedec, D. (2013). Preliminary studies on the chemical characterization and antioxidant capacity of polyphenols from Sambucus sp. Dig J Nanomater Biostruct, 8(3), 973-980.
  • Arabi, Y. M., Fowler, R., & Hayden, F.G. (2020). Critical care management of adults with community-acquired severe respiratory viral infection. Intensive Care Med, 46, 315-328.
  • Atkinson, M. D., & Atkinson, E. (2002). Sambucus nigra L. Journal of Ecology, 90(5), 895-923. https://www.jstor.org/ stable/3072258
  • Barak, V., Halperin, T., & Kalickman, I. (2001). The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw, 12(2), 290–296. Bartak, M., Lange, A., Słonska, A., & Cymerys, J. (2020). Antiviral and healing potential of Sambucus nigra extracts. Revista Bionatura, 5(3), 1264–1270.
  • Bolarinwa, I. F., Orfila, C., & Morgan, M. R. (2014). Amygdalin content of seeds, kernels and food products commer¬cially-available in the UK. Food Chem, 152, 133-139.
  • Bratu, M. M., Doroftei, E., Negreanu-Pirjol, T., Hostina, C., & Porta, S. (2012). Determination of antioxidant activity and toxicity of Sambucus nigra fruit extract using alternative methods. Food Technol and Biotechnol, 50(2), 177-182.
  • Chatterjee, A., Yasmin, T., Bagchi, D., & Stohs, S. J. (2004). Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin. Mol Cell Biochem, 265, 19–26.
  • Chen, C., Zuckerman, D. M., Brantley, S., Sharpe, M., Childress, K., Hoiczyk, E., Pendleton, A. R. (2014). Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication. BMC Vet Res, 10, 24.
  • Chen, I. Y., Moriyama, M., Chang, M. F., & Ichinohe, T. (2019). Severe acute respiratory syndrome coronavi¬rus viroporin 3a activates the NLRP3 inflammasome. Front Microbiol, 10, 50. https://doi.org/10.3389/ fmicb.2019.00050
  • Christensen, L. P., Kaack, K., & Fretté, X. C. (2008). Selection of elderberry (Sambucus nigra L.) genotypes best suited for the preparation of elderflower extracts rich in flavonoids and phenolic acids. Eur Food Res Technol, 227(1), 293-305.
  • Ciocoiu, M., Badescu, L., Badulescu, O., & Badescu, M. (2012). Intervention of Sambucus nigra polyphenolic ext¬ract in experimental arterial hypertension. Int J Med Health Sci, 6(4), 80-83. https://doi.org/10.5281/zeno¬do.1055287
  • Citores, L., Ferreras, J. M., Muñoz, R., Benı́tez, J., Jiménez, P., & Girbés, T. (2002). Targeting cancer cells with trans¬ferrin conjugates containing the non-toxic type 2 ribosome-inactivating proteins nigrin b or ebulin l. Cancer Lett, 184(1), 29-35.
  • Conti, P., Ronconi, G., Caraffa, A. L., Gallenga, C. E., Ross, R., Frydas, I., & Kritas, S. K. (2020). Induction of pro-inf-lammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents, 34(2), 327-331. https://doi.org/10.23812/conti-e
  • Dawidowicz, A. L., Wianowska, D., & Baraniak, B. (2006). The antioxidant properties of alcoholic extracts from Sambucus nigra L. (antioxidative properties of extracts). LWT- Food Sci Technol, 39(3), 308–315. https:// doi.org/10.1016/j.lwt.2005.01.005 de Benito, F. M., Iglesias, R., Ferreras, J. M., Citores, L., Camafeita, E., Méndez, E., & Girbés, T. (1998). Constitutive and inducible type 1 ribosome-inactivating proteins (RIPs) in elderberry (Sambucus nigra L.). FEBS letters, 428(1-2), 75-79. https://doi.org/10.1016/S0014-5793(98)00496-7
  • Dellagreca, M., Fiorentino, A., Monaco, P., Previtera, L., & Simonet, A. M. (2000). Cyanogenic glycosides from Sam¬bucus nigra. Natural Product Letters, 14(3), 175-182.
  • Denev, P., Ciz, M., Ambrozova, G., Lojek, A., Yanakieva, I., & Kratchanova, M. (2010). Solid-phase extraction of ber¬ries’ anthocyanins and evaluation of their antioxidative properties. Food Chem, 123(4), 1055-1061.
  • Dharmawansa, K. V., Hoskin, D. W., & Rupasinghe, H. P. (2020). Chemopreventive effect of dietary anthocyanins against gastrointestinal cancers: A review of recent advances and perspectives. Int J Mol Sci, 21(18), 6555. https://doi.org/10.3390/ijms21186555
  • Di Stadio, A., Ishai, R., Gambacorta, V., Korsch, F., Ricci, G., Della Volpe, A., & Bernitsas, E. (2020). Nutraceuticals as immune-stimulating therapy to fight COVID-19. Combination of elements to improve the efficacy. Eur Rev Med Pharmacol Sci, 24(17), 9182-9187. https://doi.org/10.26355/eurrev_202009_22869
  • Dulf, F. V., Oroian, I., Vodnar, D. C., Socaciu, C., & Pintea, A. (2013). Lipid classes and fatty acid regiodistribution in triacylglycerols of seed oils of two Sambucus species (S. nigra L. and S. ebulus L.). Molecules, 18(10), 11768-11782. https://doi.org/10.3390/molecules181011768
  • Duymuş, H. G. (2011). Türkiye’de yetişen sambucus nigra meyveleri üzerinde ön kimyasal araştırmalar. Farma¬kognozi Anabilim Dalı. Yüksek Lisans Tezi. Anadolu Üniversitesi Sağlık Bilimleri Enstitüsü, Eskişehir. https://www.proquest.com/dissertations-theses/türkiyede-yetişen-i-sambucus-nigra-meyveleri/doc¬view/2579682034/se-2?accountid=131574
  • Evans, J. M., Luby, R., Lukaczer, D., Rountree, R., Stone, P. M., Guilliams, T. G., … & Hanaway, P. J. (2020). The functional medicine approach to COVID-19: virus-specific nutraceutical and botanical agents. Integr Med, 19(1), 34-42.
  • Ferreira, S. S., Silva, A. M., & Nunes, F. M. (2020). Sambucus nigra L. Fruits and flowers: chemical composition and related bioactivities. Food Rev Int, 1-29. https://doi.org/10.1080/87559129.2020.1788578
  • Festa, J., Singh, H., Hussain, A., & Da Boit, M. (2022). Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment. J Food Biochem, 00, e14091. https://doi.org/10.1111/jfbc.14091
  • Fink, R. C., Roschek Jr, B., & Alberte, R. S. (2009). HIV type-1 entry inhibitors with a new mode of action. Antivir Chem Chemother, 19(6), 243-255. https://doi.org/10.1177/095632020901900604
  • Frøkiær, H., Henningsen, L., Metzdorff, S. B., Weiss, G., Roller, M., Flanagan, J., ... & Ibarra, A. (2012). Astragalus root and elderberry fruit extracts enhance the IFN-β stimulatory effects of Lactobacillus acidophilus in muri¬ne-derived dendritic cells. PLoS One, 7(10), e47878. https://doi.org/10.1371/journal.pone.0047878
  • Galić, A., Dragović-Uzelac, V., Levaj, B., Bursać Kovačević, D., Pliestić, S., & Arnautović, S. (2009). The Polyphenols Stability, Enzyme Activity and Physico-Chemical Parameters During Producing Wild Elderberry Concent¬rated Juice. Agric Conspec Sci, 74(3), 181-186.
  • Gao, F., Bailes, E., Robertson, D. L., Chen, Y., Rodenburg, C. M., Michael, S. F., ... & Hahn, B. H. (1999). Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature, 397, 436-441. https://doi.org/10.1038/17130
  • Gleeson, M. (2013). Exercise, nutrition and immunity. Philip C. Calder, Parveen Yaqoob (Ed.), Diet, immunity and inflammation içinde (s. 652-685). Woodhead Publishing. https://doi.org/10.1533/9780857095749.4.652
  • Hawkins, J., Baker, C., Cherry, L., & Dunne, E. (2019). Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Comple¬ment Ther Med, 42, 361–365. https://doi.org/10.1016/j.ctim.2018.12.004
  • Hearst, C., McCollum, G., Nelson, D., Ballard, L. M., Millar, B. C., Goldsmith, C. E., ... & Rao, J. R. (2010). Antibacterial activity of elder (Sambucus nigra L.) flower or berry against hospital pathogens. J Med Plant Res, 4(17), 1805-1809.
  • Imenšek, N., Sem, V., Kolar, M., Ivančič, A., & Kristl, J. (2021). The Distribution of Minerals in Crucial Plant Parts of Various Elderberry (Sambucus spp.) Interspecific Hybrids. Plants, 10(4), 653. https://doi.org/10.3390/ plants10040653
  • Istanbuly, M. N. (2018). Elderberry (Sambucus nigra) Distribution and Abundance in Syria. Journal of University of Babylon for Engineering Sciences, 26(10), 273-285. https://journalofbabylon.com/index.php/JUBES/artic¬le/view/1884
  • Kaack, K., & Christensen, L. P. (2010). Phenolic acids and flavonoids in tea processed from flowers of black elder (Sambucus nigra L.) stored in different packing materials. Eur J Hortic Sci, 75(5), 214-220.
  • Kislichenko, V. S., & Vel´ma, V. V. (2006). Amino-acid composition of flowers, leaves, and extract of Sambucus nigra flowers. Chem Nat Compd, 42(1), 125-126. https://doi.org/10.1007/s10600-006-0058-x
  • Krawitz, C., Mraheil, M. A., Stein, M., Imirzalioglu, C., Domann, E., Pleschka, S., & Hain, T. (2011). Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Med Ther, 11(1), 16. https://doi.org/10.1186/1472-6882-11-16
  • Küçükcankurtaran, S., & Özdoğan, Y. (2021). Koronavirüs Hastalığı’nın Yetişkinlerin Beslenme ve Fiziksel Aktivite Durumuna Etkisi; COVID-19 ve Beslenme. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 11(3), 318-324.
  • Mikulic-Petkovsek, M., Ivancic, A., Schmitzer, V., Veberic, R., & Stampar, F. (2016). Comparison of major taste com¬pounds and antioxidative properties of fruits and flowers of different Sambucus species and interspecific hybrids. Food Chem, 200, 134-140. https://doi.org/10.1016/j.foodchem.2016.01.044
  • Mikulic‐Petkovsek, M., Ivancic, A., Todorovic, B., Veberic, R., & Stampar, F. (2015). Fruit phenolic composition of diffe¬rent elderberry species and hybrids. J Food Sci, 80(10), C2180-C2190. https://doi.org/10.1111/1750-3841.13008
  • Mladěnka, P., Říha, M., Martin, J., Gorová, B., Matějíček, A., & Spilková, J. (2016). Fruit extracts of 10 varieties of elderberry (Sambucus nigra L.) interact differently with iron and copper. Phytochem Lett, 18, 232-238.
  • Młynarczyk, K., Walkowiak-Tomczak, D., & Łysiak, G. P. (2018). Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry. J Funct Foods, 40, 377–390. https://doi.or¬g/10.1016/J.JFF.2017.11.025
  • Mratinić, E., & Fotirić, M. (2007). Selection of black elderberry (Sambucus nigra L.) and evaluation of its fruits usability as biologically valuable food. Genetika, 39(3), 305-314.
  • Nohutçu, L., Tunçtürk, M., & Tunçtürk, R. (2019). Yabani Bitkiler ve Sürdürülebilirlik. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 24(2), 142-151.
  • Özay, C. Koronavirüs Hastalığı’nda (COVID-19) Bağışıklık Sistemi Üzerinde Etki Gösteren Bazı Önemli Tıbbi Bitkiler ve Kullanılabilirlikleri. (2022). İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 7(1), 117-121.
  • Porter, R. S., & Bode, R. F. (2017). A review of the antiviral properties of black elder (Sambucus nigra L.) products. Phytother Res, 31, 533-554. https://doi.org/10.1002/ptr.5782
  • Sadilova, E., Stintzing, F. C., Kammerer, D. R., & Carle, R. (2009). Matrix dependent impact of sugar and ascorbic acid addition on color and anthocyanin stability of black carrot, elderberry and strawberry single strength and from concentrate juices upon thermal treatment. Food Res Int, 42(8), 1023-1033. https://doi.org/10.1016/j.foodres.2009.04.008
  • Schmitzer, V., Veberic, R., & Stampar, F. (2012). European elderberry (Sambucus nigra L.) and American elderberry (Sambucus Canadensis L.): Botanical, chemical and health properties of flowers, berries and their pro¬ducts. Carlo Tuberoso (Ed.), Berries: Properties, Consumption and Nutrition içinde (s. 127-144). New York: Nova Biomedical. https://www.researchgate.net/publication/267033120
  • Sibuyi, N. R. S., Thipe, V. C., Panjtan-Amiri, K., Meyer, M., & Katti, K. V. (2021). Green synthesis of gold nanoparticles using Acai berry and Elderberry extracts and investigation of their effect on prostate and pancreatic cancer cells. Nanobiomedicine, 8, 1849543521995310. https://doi.org/10.1177%2F1849543521995310
  • Sidor, A., & Gramza-Michałowska, A. (2015). Advanced research on the antioxidant and health benefit of elder¬berry (Sambucus nigra) in food–a review. J Funct Foods, 18, 941-958. https://doi.org/10.1016/j.jff.2014.07.012
  • Simonyi, A., Chen, Z., Jiang, J., Zong, Y., Chuang, D. Y., Gu, Z., ... & Sun, G. Y. (2015). Inhibition of microglial activa¬tion by elderberry extracts and its phenolic components. Life Sci, 128, 30-38. https://doi.org/10.1016/j. lfs.2015.01.037
  • Sönmezışık, N., Arslanoğlu, Ş. F., Öztürk, R., & Baştürk, M. H. (2021). Rooting of black elderberry (Sambucus nigra L.) by treating of indole-3-acetic acid. Turk J Food Agric Sci, 3(2), 45-49.
  • Tejero, J., Jiménez, P., Quinto, E. J., Cordoba-Diaz, D., Garrosa, M., Cordoba-Diaz, M., ... & Girbés, T. (2015). Elderberries: A source of ribosome-inactivating proteins with lectin activity. Molecules, 20(2), 2364-2387. https://doi. org/10.3390/molecules20022364
  • Thole, J. M., Kraft, T. F. B., Sueiro, L. A., Kang, Y. H., Gills, J. J., Cuendet M., … & Lila, M. A. (2006). A comparative evalu-ation of the anticancer properties of European and American elderberry fruits. J Med Food, 9(4), 498-504. https://doi.org/10.1089/jmf.2006.9.498
  • Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry supplementation reduces cold duration and symptoms in air-travellers: A randomized, double-blind placebo-controlled clinical trial. Nutrients, 8(4), 182. https://doi. org/10.3390/nu8040182
  • Uçar, D., Tayfun, K., Müslümanoğlu, A. Y., & Kalaycı, M. Z. (2020). Coronavirus ve Fitoterapi. Bütünleyici ve Anadolu Tıbbı Dergisi, 1(2), 49-57.
  • Van Damme, E. J., Charels, D., Roy, S., Tierens, K., Barre, A., Martins, J. C., ... & Peumans, W. J. (1999). A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes. Plant Physiol, 119(4), 1547-1556. https://doi.org/10.1104/pp.119.4.1547
  • Van Damme, E. J., Roy, S., Barre, A., Rougé, P., Van Leuven, F., & Peumans, W. J. (1997). The major elderberry (Sam¬bucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome‐inactivating protein. Plant J, 12(6), 1251-1260. https://doi.org/10.1046/j.1365-313x.1997.12061251.x
  • Van Schoor, J. (2020). Ways to streng then the immune system. South African Pharmacist’s Assistant, 20(4), 13-14.
  • Veberic, R., Jakopic, J., Stampar, F., & Schmitzer, V. (2009). European elderberry (Sambucus nigra L.) rich in sugars, organic acids, anthocyanins and selected polyphenols. Food Chem, 114, 511-515.
  • Vulić, J. J., Vračar, L. O., & Šumić, Z. M. (2008). Chemical characteristics of cultivated elderberry fruit. Acta Periodica Technologica, 39, 85-90.
  • Weng, J. R., Lin, C. S., Lai, H. C., Lin, Y. P., Wang, C. Y., Tsai, Y. C., ... & Lin, C. W. (2019). Antiviral activity of Sambucus For¬mosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63. Virus Res, 273, 197767. https://doi.org/10.1016/j.virusres.2019.197767 Wermig-Morgan, J. H. (2020). Elderberry is anti-bacterial, anti-viral and modulates the immune system: anti-ba¬cterial, anti-viral and immunomodulatory non-clinical (in-vitro) effects of elderberry fruit and flowers (Sambucus nigra): a systematic review. Master’s dissertion. University of Oxford. https://www.research¬gate.net/publication/339237008
  • WHO. (2020). Director-General’s opening remarks at the media briefing on COVID-19. https://www.who.int/direc¬tor-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media -briefing-on-covid-19
  • Wieland, L. S., Piechotta, V., Feinberg, T., Ludeman, E., Hutton, B., Kanji, S., ... & Garritty, C. (2021). Elderberry for preven¬tion and treatment of viral respiratory illnesses: A systematic review. BMC Complement Med Ther, 21(1), 112. https://doi.org/10.1186/s12906-021-03283-5
  • Zafra-Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., & Bagchi, D. (2007). Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res , 51(6), 675–683. https://doi. org/10.1002/mnfr.200700002
  • Zakay-Rones, Z., Thom, E., Wollan, T., & Wadstein, J. (2004). Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res, 32(2), 132-140.
  • Zielińska-Wasielica, J., Olejnik, A., Kowalska, K., Olkowicz, M., & Dembczyński, R. (2019). Elderberry (Sambucus nigra L.) fruit extract alleviates oxidative stress, insulin resistance, and inflammation in hypertrophied 3T3-L1 adipocytes and activated RAW 264.7 macrophages. Foods, 8(8), 326. https://doi.org/10.3390/foo¬ds8080326

KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ

Yıl 2023, , 11 - 26, 29.04.2023

Başak Öney , Zehra Başer

https://doi.org/10.47115/jshs.1084660

Öz

Kara mürver, latince ismiyle Sambucus nigra, uzun yıllardır kullanılan Adoxaceae
familyasına ait bir bitkidir. Ortak isimleri arasında kara mürver, siyah yaşlı,
Avrupa yaşlısı, Avrupa mürveri ve Avrupa kara mürveri de vardır. Hipokrat
tarafından doğanın en şifalı bitkisi olarak görüldüğü de bilinmektedir. Meyveleri
koyu mor-siyah renktedir. 100 gramı ortalama 73 kalori içerir ve vitamin-mineral
açısından oldukça zengin bir yapıya sahiptir. Kara mürver, yapısında birçok faydalı
bileşik bulundurmaktadır. Bunlar arasında en önemli olanlar flavonoidler, fenolik
asitler ve antosiyaninlerdir. En baskın olanı ise antioksidan özelliği olduğu bilinen
antosiyaninlerdir. Bunların yanında kara mürver, içerdiği siyanojenik glikozitlerden
kaynaklı olarak zehirlenmeye sebep olabilmektedir. Bunu önleyebilmek için
mutlaka ısıl işleme maruz bırakıldıktan sonra tüketilmesi gerekmektedir. Kara
mürverin diüretik, laksatif, diyaforetik, antioksidan, antiviral, immünomodülatör,
antiinflamatuar, antimikrobiyal, antikonvülsan, antidepresan ve antikarsinojenik
gibi çeşitli etkilere sahip olduğu bilinmektedir. Aynı zamanda diyabet, hipertansiyon,
obezite, hiperlipidemi, metabolik işlev bozuklukları, üriner parametreler
üzerinde de kullanılabilmektedir. Hem sağlıklı hem de hasta organizmalarda vücudun
savunma mekanizmalarını düzenlemeye destek olarak bağışıklık sistemini
güçlendirdiği bilinmektedir. Henüz çalışmalar yetersiz olsa da COVID-19 için de
kullanılabileceği düşünülmektedir. Bu derlemede kara mürverin antioksidan, antiviral,
antibakteriyel, antiinflamatuar, antikanser etkileri ve bağışıklık sistemiyle
ilişkisinden bahsedilmiştir.

Anahtar Kelimeler

kara mürver Sambucus nigra bağışıklık sistemi antiviral Kara Mürver ve Bağışıklık COVID-19

Kaynakça

  • Aguzzi, C., Marinelli, O., Zeppa, L., Santoni, G., Maggi, F., & Nabissi, M. (2020). Evaluation of anti-inflammatory and immunoregulatory activities of Stimunex® and Stimunex D3® in human monocytes/macrophages stimu¬lated with LPS or IL-4/IL-13. Biomedicine & Pharmacotherapy, 132, 110845. https://doi.org/10.1016/j.biopha.2020.110845
  • Ağalar, H. G. (2019). Elderberry (Sambucus nigra L.). Seyed Mohammad Nabavi, Ana Sanches Silva (Ed.), Nonvitamin and Nonmineral Nutritional Supplements içinde (s. 211-215). Academic Press. https://doi.org/10.1016/B978- 0-12-812491-8.00030-8
  • Alıç, B., Olcay, N., & Demir, M. K. (2021). Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellik¬leri. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 11(2), 1140-1153.
  • Anton, A. M., Pintea, A. M., Rugină, D. O., Sconţa, Z. M., Hanganu, D., Vlase, L., & Benedec, D. (2013). Preliminary studies on the chemical characterization and antioxidant capacity of polyphenols from Sambucus sp. Dig J Nanomater Biostruct, 8(3), 973-980.
  • Arabi, Y. M., Fowler, R., & Hayden, F.G. (2020). Critical care management of adults with community-acquired severe respiratory viral infection. Intensive Care Med, 46, 315-328.
  • Atkinson, M. D., & Atkinson, E. (2002). Sambucus nigra L. Journal of Ecology, 90(5), 895-923. https://www.jstor.org/ stable/3072258
  • Barak, V., Halperin, T., & Kalickman, I. (2001). The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw, 12(2), 290–296. Bartak, M., Lange, A., Słonska, A., & Cymerys, J. (2020). Antiviral and healing potential of Sambucus nigra extracts. Revista Bionatura, 5(3), 1264–1270.
  • Bolarinwa, I. F., Orfila, C., & Morgan, M. R. (2014). Amygdalin content of seeds, kernels and food products commer¬cially-available in the UK. Food Chem, 152, 133-139.
  • Bratu, M. M., Doroftei, E., Negreanu-Pirjol, T., Hostina, C., & Porta, S. (2012). Determination of antioxidant activity and toxicity of Sambucus nigra fruit extract using alternative methods. Food Technol and Biotechnol, 50(2), 177-182.
  • Chatterjee, A., Yasmin, T., Bagchi, D., & Stohs, S. J. (2004). Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin. Mol Cell Biochem, 265, 19–26.
  • Chen, C., Zuckerman, D. M., Brantley, S., Sharpe, M., Childress, K., Hoiczyk, E., Pendleton, A. R. (2014). Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication. BMC Vet Res, 10, 24.
  • Chen, I. Y., Moriyama, M., Chang, M. F., & Ichinohe, T. (2019). Severe acute respiratory syndrome coronavi¬rus viroporin 3a activates the NLRP3 inflammasome. Front Microbiol, 10, 50. https://doi.org/10.3389/ fmicb.2019.00050
  • Christensen, L. P., Kaack, K., & Fretté, X. C. (2008). Selection of elderberry (Sambucus nigra L.) genotypes best suited for the preparation of elderflower extracts rich in flavonoids and phenolic acids. Eur Food Res Technol, 227(1), 293-305.
  • Ciocoiu, M., Badescu, L., Badulescu, O., & Badescu, M. (2012). Intervention of Sambucus nigra polyphenolic ext¬ract in experimental arterial hypertension. Int J Med Health Sci, 6(4), 80-83. https://doi.org/10.5281/zeno¬do.1055287
  • Citores, L., Ferreras, J. M., Muñoz, R., Benı́tez, J., Jiménez, P., & Girbés, T. (2002). Targeting cancer cells with trans¬ferrin conjugates containing the non-toxic type 2 ribosome-inactivating proteins nigrin b or ebulin l. Cancer Lett, 184(1), 29-35.
  • Conti, P., Ronconi, G., Caraffa, A. L., Gallenga, C. E., Ross, R., Frydas, I., & Kritas, S. K. (2020). Induction of pro-inf-lammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents, 34(2), 327-331. https://doi.org/10.23812/conti-e
  • Dawidowicz, A. L., Wianowska, D., & Baraniak, B. (2006). The antioxidant properties of alcoholic extracts from Sambucus nigra L. (antioxidative properties of extracts). LWT- Food Sci Technol, 39(3), 308–315. https:// doi.org/10.1016/j.lwt.2005.01.005 de Benito, F. M., Iglesias, R., Ferreras, J. M., Citores, L., Camafeita, E., Méndez, E., & Girbés, T. (1998). Constitutive and inducible type 1 ribosome-inactivating proteins (RIPs) in elderberry (Sambucus nigra L.). FEBS letters, 428(1-2), 75-79. https://doi.org/10.1016/S0014-5793(98)00496-7
  • Dellagreca, M., Fiorentino, A., Monaco, P., Previtera, L., & Simonet, A. M. (2000). Cyanogenic glycosides from Sam¬bucus nigra. Natural Product Letters, 14(3), 175-182.
  • Denev, P., Ciz, M., Ambrozova, G., Lojek, A., Yanakieva, I., & Kratchanova, M. (2010). Solid-phase extraction of ber¬ries’ anthocyanins and evaluation of their antioxidative properties. Food Chem, 123(4), 1055-1061.
  • Dharmawansa, K. V., Hoskin, D. W., & Rupasinghe, H. P. (2020). Chemopreventive effect of dietary anthocyanins against gastrointestinal cancers: A review of recent advances and perspectives. Int J Mol Sci, 21(18), 6555. https://doi.org/10.3390/ijms21186555
  • Di Stadio, A., Ishai, R., Gambacorta, V., Korsch, F., Ricci, G., Della Volpe, A., & Bernitsas, E. (2020). Nutraceuticals as immune-stimulating therapy to fight COVID-19. Combination of elements to improve the efficacy. Eur Rev Med Pharmacol Sci, 24(17), 9182-9187. https://doi.org/10.26355/eurrev_202009_22869
  • Dulf, F. V., Oroian, I., Vodnar, D. C., Socaciu, C., & Pintea, A. (2013). Lipid classes and fatty acid regiodistribution in triacylglycerols of seed oils of two Sambucus species (S. nigra L. and S. ebulus L.). Molecules, 18(10), 11768-11782. https://doi.org/10.3390/molecules181011768
  • Duymuş, H. G. (2011). Türkiye’de yetişen sambucus nigra meyveleri üzerinde ön kimyasal araştırmalar. Farma¬kognozi Anabilim Dalı. Yüksek Lisans Tezi. Anadolu Üniversitesi Sağlık Bilimleri Enstitüsü, Eskişehir. https://www.proquest.com/dissertations-theses/türkiyede-yetişen-i-sambucus-nigra-meyveleri/doc¬view/2579682034/se-2?accountid=131574
  • Evans, J. M., Luby, R., Lukaczer, D., Rountree, R., Stone, P. M., Guilliams, T. G., … & Hanaway, P. J. (2020). The functional medicine approach to COVID-19: virus-specific nutraceutical and botanical agents. Integr Med, 19(1), 34-42.
  • Ferreira, S. S., Silva, A. M., & Nunes, F. M. (2020). Sambucus nigra L. Fruits and flowers: chemical composition and related bioactivities. Food Rev Int, 1-29. https://doi.org/10.1080/87559129.2020.1788578
  • Festa, J., Singh, H., Hussain, A., & Da Boit, M. (2022). Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment. J Food Biochem, 00, e14091. https://doi.org/10.1111/jfbc.14091
  • Fink, R. C., Roschek Jr, B., & Alberte, R. S. (2009). HIV type-1 entry inhibitors with a new mode of action. Antivir Chem Chemother, 19(6), 243-255. https://doi.org/10.1177/095632020901900604
  • Frøkiær, H., Henningsen, L., Metzdorff, S. B., Weiss, G., Roller, M., Flanagan, J., ... & Ibarra, A. (2012). Astragalus root and elderberry fruit extracts enhance the IFN-β stimulatory effects of Lactobacillus acidophilus in muri¬ne-derived dendritic cells. PLoS One, 7(10), e47878. https://doi.org/10.1371/journal.pone.0047878
  • Galić, A., Dragović-Uzelac, V., Levaj, B., Bursać Kovačević, D., Pliestić, S., & Arnautović, S. (2009). The Polyphenols Stability, Enzyme Activity and Physico-Chemical Parameters During Producing Wild Elderberry Concent¬rated Juice. Agric Conspec Sci, 74(3), 181-186.
  • Gao, F., Bailes, E., Robertson, D. L., Chen, Y., Rodenburg, C. M., Michael, S. F., ... & Hahn, B. H. (1999). Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature, 397, 436-441. https://doi.org/10.1038/17130
  • Gleeson, M. (2013). Exercise, nutrition and immunity. Philip C. Calder, Parveen Yaqoob (Ed.), Diet, immunity and inflammation içinde (s. 652-685). Woodhead Publishing. https://doi.org/10.1533/9780857095749.4.652
  • Hawkins, J., Baker, C., Cherry, L., & Dunne, E. (2019). Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Comple¬ment Ther Med, 42, 361–365. https://doi.org/10.1016/j.ctim.2018.12.004
  • Hearst, C., McCollum, G., Nelson, D., Ballard, L. M., Millar, B. C., Goldsmith, C. E., ... & Rao, J. R. (2010). Antibacterial activity of elder (Sambucus nigra L.) flower or berry against hospital pathogens. J Med Plant Res, 4(17), 1805-1809.
  • Imenšek, N., Sem, V., Kolar, M., Ivančič, A., & Kristl, J. (2021). The Distribution of Minerals in Crucial Plant Parts of Various Elderberry (Sambucus spp.) Interspecific Hybrids. Plants, 10(4), 653. https://doi.org/10.3390/ plants10040653
  • Istanbuly, M. N. (2018). Elderberry (Sambucus nigra) Distribution and Abundance in Syria. Journal of University of Babylon for Engineering Sciences, 26(10), 273-285. https://journalofbabylon.com/index.php/JUBES/artic¬le/view/1884
  • Kaack, K., & Christensen, L. P. (2010). Phenolic acids and flavonoids in tea processed from flowers of black elder (Sambucus nigra L.) stored in different packing materials. Eur J Hortic Sci, 75(5), 214-220.
  • Kislichenko, V. S., & Vel´ma, V. V. (2006). Amino-acid composition of flowers, leaves, and extract of Sambucus nigra flowers. Chem Nat Compd, 42(1), 125-126. https://doi.org/10.1007/s10600-006-0058-x
  • Krawitz, C., Mraheil, M. A., Stein, M., Imirzalioglu, C., Domann, E., Pleschka, S., & Hain, T. (2011). Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Med Ther, 11(1), 16. https://doi.org/10.1186/1472-6882-11-16
  • Küçükcankurtaran, S., & Özdoğan, Y. (2021). Koronavirüs Hastalığı’nın Yetişkinlerin Beslenme ve Fiziksel Aktivite Durumuna Etkisi; COVID-19 ve Beslenme. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 11(3), 318-324.
  • Mikulic-Petkovsek, M., Ivancic, A., Schmitzer, V., Veberic, R., & Stampar, F. (2016). Comparison of major taste com¬pounds and antioxidative properties of fruits and flowers of different Sambucus species and interspecific hybrids. Food Chem, 200, 134-140. https://doi.org/10.1016/j.foodchem.2016.01.044
  • Mikulic‐Petkovsek, M., Ivancic, A., Todorovic, B., Veberic, R., & Stampar, F. (2015). Fruit phenolic composition of diffe¬rent elderberry species and hybrids. J Food Sci, 80(10), C2180-C2190. https://doi.org/10.1111/1750-3841.13008
  • Mladěnka, P., Říha, M., Martin, J., Gorová, B., Matějíček, A., & Spilková, J. (2016). Fruit extracts of 10 varieties of elderberry (Sambucus nigra L.) interact differently with iron and copper. Phytochem Lett, 18, 232-238.
  • Młynarczyk, K., Walkowiak-Tomczak, D., & Łysiak, G. P. (2018). Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry. J Funct Foods, 40, 377–390. https://doi.or¬g/10.1016/J.JFF.2017.11.025
  • Mratinić, E., & Fotirić, M. (2007). Selection of black elderberry (Sambucus nigra L.) and evaluation of its fruits usability as biologically valuable food. Genetika, 39(3), 305-314.
  • Nohutçu, L., Tunçtürk, M., & Tunçtürk, R. (2019). Yabani Bitkiler ve Sürdürülebilirlik. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 24(2), 142-151.
  • Özay, C. Koronavirüs Hastalığı’nda (COVID-19) Bağışıklık Sistemi Üzerinde Etki Gösteren Bazı Önemli Tıbbi Bitkiler ve Kullanılabilirlikleri. (2022). İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 7(1), 117-121.
  • Porter, R. S., & Bode, R. F. (2017). A review of the antiviral properties of black elder (Sambucus nigra L.) products. Phytother Res, 31, 533-554. https://doi.org/10.1002/ptr.5782
  • Sadilova, E., Stintzing, F. C., Kammerer, D. R., & Carle, R. (2009). Matrix dependent impact of sugar and ascorbic acid addition on color and anthocyanin stability of black carrot, elderberry and strawberry single strength and from concentrate juices upon thermal treatment. Food Res Int, 42(8), 1023-1033. https://doi.org/10.1016/j.foodres.2009.04.008
  • Schmitzer, V., Veberic, R., & Stampar, F. (2012). European elderberry (Sambucus nigra L.) and American elderberry (Sambucus Canadensis L.): Botanical, chemical and health properties of flowers, berries and their pro¬ducts. Carlo Tuberoso (Ed.), Berries: Properties, Consumption and Nutrition içinde (s. 127-144). New York: Nova Biomedical. https://www.researchgate.net/publication/267033120
  • Sibuyi, N. R. S., Thipe, V. C., Panjtan-Amiri, K., Meyer, M., & Katti, K. V. (2021). Green synthesis of gold nanoparticles using Acai berry and Elderberry extracts and investigation of their effect on prostate and pancreatic cancer cells. Nanobiomedicine, 8, 1849543521995310. https://doi.org/10.1177%2F1849543521995310
  • Sidor, A., & Gramza-Michałowska, A. (2015). Advanced research on the antioxidant and health benefit of elder¬berry (Sambucus nigra) in food–a review. J Funct Foods, 18, 941-958. https://doi.org/10.1016/j.jff.2014.07.012
  • Simonyi, A., Chen, Z., Jiang, J., Zong, Y., Chuang, D. Y., Gu, Z., ... & Sun, G. Y. (2015). Inhibition of microglial activa¬tion by elderberry extracts and its phenolic components. Life Sci, 128, 30-38. https://doi.org/10.1016/j. lfs.2015.01.037
  • Sönmezışık, N., Arslanoğlu, Ş. F., Öztürk, R., & Baştürk, M. H. (2021). Rooting of black elderberry (Sambucus nigra L.) by treating of indole-3-acetic acid. Turk J Food Agric Sci, 3(2), 45-49.
  • Tejero, J., Jiménez, P., Quinto, E. J., Cordoba-Diaz, D., Garrosa, M., Cordoba-Diaz, M., ... & Girbés, T. (2015). Elderberries: A source of ribosome-inactivating proteins with lectin activity. Molecules, 20(2), 2364-2387. https://doi. org/10.3390/molecules20022364
  • Thole, J. M., Kraft, T. F. B., Sueiro, L. A., Kang, Y. H., Gills, J. J., Cuendet M., … & Lila, M. A. (2006). A comparative evalu-ation of the anticancer properties of European and American elderberry fruits. J Med Food, 9(4), 498-504. https://doi.org/10.1089/jmf.2006.9.498
  • Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry supplementation reduces cold duration and symptoms in air-travellers: A randomized, double-blind placebo-controlled clinical trial. Nutrients, 8(4), 182. https://doi. org/10.3390/nu8040182
  • Uçar, D., Tayfun, K., Müslümanoğlu, A. Y., & Kalaycı, M. Z. (2020). Coronavirus ve Fitoterapi. Bütünleyici ve Anadolu Tıbbı Dergisi, 1(2), 49-57.
  • Van Damme, E. J., Charels, D., Roy, S., Tierens, K., Barre, A., Martins, J. C., ... & Peumans, W. J. (1999). A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes. Plant Physiol, 119(4), 1547-1556. https://doi.org/10.1104/pp.119.4.1547
  • Van Damme, E. J., Roy, S., Barre, A., Rougé, P., Van Leuven, F., & Peumans, W. J. (1997). The major elderberry (Sam¬bucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome‐inactivating protein. Plant J, 12(6), 1251-1260. https://doi.org/10.1046/j.1365-313x.1997.12061251.x
  • Van Schoor, J. (2020). Ways to streng then the immune system. South African Pharmacist’s Assistant, 20(4), 13-14.
  • Veberic, R., Jakopic, J., Stampar, F., & Schmitzer, V. (2009). European elderberry (Sambucus nigra L.) rich in sugars, organic acids, anthocyanins and selected polyphenols. Food Chem, 114, 511-515.
  • Vulić, J. J., Vračar, L. O., & Šumić, Z. M. (2008). Chemical characteristics of cultivated elderberry fruit. Acta Periodica Technologica, 39, 85-90.
  • Weng, J. R., Lin, C. S., Lai, H. C., Lin, Y. P., Wang, C. Y., Tsai, Y. C., ... & Lin, C. W. (2019). Antiviral activity of Sambucus For¬mosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63. Virus Res, 273, 197767. https://doi.org/10.1016/j.virusres.2019.197767 Wermig-Morgan, J. H. (2020). Elderberry is anti-bacterial, anti-viral and modulates the immune system: anti-ba¬cterial, anti-viral and immunomodulatory non-clinical (in-vitro) effects of elderberry fruit and flowers (Sambucus nigra): a systematic review. Master’s dissertion. University of Oxford. https://www.research¬gate.net/publication/339237008
  • WHO. (2020). Director-General’s opening remarks at the media briefing on COVID-19. https://www.who.int/direc¬tor-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media -briefing-on-covid-19
  • Wieland, L. S., Piechotta, V., Feinberg, T., Ludeman, E., Hutton, B., Kanji, S., ... & Garritty, C. (2021). Elderberry for preven¬tion and treatment of viral respiratory illnesses: A systematic review. BMC Complement Med Ther, 21(1), 112. https://doi.org/10.1186/s12906-021-03283-5
  • Zafra-Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., & Bagchi, D. (2007). Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res , 51(6), 675–683. https://doi. org/10.1002/mnfr.200700002
  • Zakay-Rones, Z., Thom, E., Wollan, T., & Wadstein, J. (2004). Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res, 32(2), 132-140.
  • Zielińska-Wasielica, J., Olejnik, A., Kowalska, K., Olkowicz, M., & Dembczyński, R. (2019). Elderberry (Sambucus nigra L.) fruit extract alleviates oxidative stress, insulin resistance, and inflammation in hypertrophied 3T3-L1 adipocytes and activated RAW 264.7 macrophages. Foods, 8(8), 326. https://doi.org/10.3390/foo¬ds8080326
Toplam 68 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Başak Öney 0000-0003-2695-6978

Zehra Başer 0000-0002-9430-5352

Erken Görünüm Tarihi 29 Nisan 2023
Yayımlanma Tarihi 29 Nisan 2023
Gönderilme Tarihi 9 Mart 2022
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

APA Öney, B., & Başer, Z. (2023). KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ. Samsun Sağlık Bilimleri Dergisi, 8(1), 11-26. https://doi.org/10.47115/jshs.1084660
AMA Öney B, Başer Z. KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ. JSHS. Nisan 2023;8(1):11-26. doi:10.47115/jshs.1084660
Chicago Öney, Başak, ve Zehra Başer. “KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ”. Samsun Sağlık Bilimleri Dergisi 8, sy. 1 (Nisan 2023): 11-26. https://doi.org/10.47115/jshs.1084660.
EndNote Öney B, Başer Z (01 Nisan 2023) KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ. Samsun Sağlık Bilimleri Dergisi 8 1 11–26.
IEEE B. Öney ve Z. Başer, “KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ”, JSHS, c. 8, sy. 1, ss. 11–26, 2023, doi: 10.47115/jshs.1084660.
ISNAD Öney, Başak - Başer, Zehra. “KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ”. Samsun Sağlık Bilimleri Dergisi 8/1 (Nisan 2023), 11-26. https://doi.org/10.47115/jshs.1084660.
JAMA Öney B, Başer Z. KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ. JSHS. 2023;8:11–26.
MLA Öney, Başak ve Zehra Başer. “KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ”. Samsun Sağlık Bilimleri Dergisi, c. 8, sy. 1, 2023, ss. 11-26, doi:10.47115/jshs.1084660.
Vancouver Öney B, Başer Z. KARA MÜRVERİN BAĞIŞIKLIK SİSTEMİ ÜZERİNE ETKİSİ. JSHS. 2023;8(1):11-26.

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