THE EFFECTS OF ASTAXANTHIN ON THE NERVOUS SYSTEM

Yıl 2022, , 657 - 674, 30.12.2022

Ayris Gökçeoğlu , Gül Fatma Yarım

https://doi.org/10.47115/jshs.1110610

Öz

Astaxanthin is an antioxidant carotenoid abundant in the shells of crustaceans, salmon, trout, and other marine organisms. In both in vivo and in vitro experiments, astaxanthin has been proven to have a considerable impact on the neurological system. Astaxanthin exhibits these effects by modulating inflammation, suppressing oxidative stress, showing antioxidant effects, and suppressing neuronal apoptosis. In addition to its antioxidant, anti-inflammatory, and anti-apoptotic properties, astaxanthin has the potential to be used in the prophylaxis and treatment of neurological disorders due to its ability to cross the blood-brain barrier. Astaxanthin's commercial availability, lack of side effects, protective and therapeutic properties on the nervous system suggest that it may be a promising option in the future. In this review, information about the role of astaxanthin in the nervous system and its effects on neurological disorders are summarized.

Anahtar Kelimeler

Astaxanthin, Antioxidant, Neurological disorders, Neuroprotective

Astaksantinin Sinir Sistemi Üzerindeki Etkileri

Öz

Astaksantin, kabuklular, somon, alabalık ve diğer deniz organizmalarının kabuklarında bol miktarda bulunan bir antioksidan karotenoiddir. Astaksantinin nörolojik sistem üzerinde önemli etkiler gösterdiği gerek in vivo gerekse de in vitro çalışmalar sonucunda kanıtlanmıştır. Astaksantin anılan bu etkilerini, inflamasyonu modüle ederek, oksidatif stresi baskılayarak, antioksidan etki göstererek ve nöronal apoptozu baskılayarak sergilemektedir. Antioksidan, anti-inflamatuar ve anti-apoptotik niteliklerinin yanı sıra astaksantin kan-beyin bariyerini geçebilmesi nedeniyle nörolojik bozuklukların profilaksisinde ve tedavisinde kullanılma potansiyeline sahiptir. Astaksantinin ticari olarak bulunabilirliği, yan etkisinin olmayışı, sinir sistemi üzerindeki koruyucu ve tedavi edici nitelikleri, gelecekte umut vadeden bir seçenek olabileceğini düşündürmektedir. Bu derlemede, astaksantinin sinir sistemindeki rolü ve nörolojik bozukluklardaki etkileri hakkında bilgiler özetlenmiştir.

Anahtar Kelimeler

Astaksantin, Antioksidan, Nörolojik bozukluklar, Nöroprotektif

Kaynakça

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