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The Role of Chemerin In Polycystic Over Syndrome

Yıl 2021, Cilt: 6 Sayı: 2, 197 - 210, 31.08.2021
https://doi.org/10.47115/jshs.752616

Öz

Polycystic ovarian syndrome (PCOS) is a heterogeneous disease defined by a combination of androgen excess and ovarian dysfunction. Although the etiology of PCOS is not fully known, hyperandrogenism, obesity, dyslipidemia, chronic inflammation and insulin resistance have a significant impact on the development of the syndrome. Adipose tissue, especially white adipose tissue, is under the influence of sex steroids, this effect is versatile and complex. Adipose tissue is prone to hypertrophy when exposed to androgen excess, and both adipose tissue hypertrophy and hyperandrogenism are associated with insulin resistance. Chronic low-grade inflammation caused by adipose tissue disorder has also been shown to play a role in the development of metabolic and reproductive disorders of PCOS. Chemerin, recently joined the adipokine family as a new chemoattractant protein. Chemerin has been shown in studies to play an important role in differentiation of human adipocytes, inflammation, glucose and lipid metabolism. It is thought that chemerin may contribute to the development of PCOS by associating it with insulin resistance and its inflammatory role as a chemoattractant substance in adipose tissue. In recent studies, serum chemerin concentrations have been found significantly higher in PCOS patients compared to healthy individuals and chemerin has been associated with body mass index, blood lipids, insulin resistance and hyperandrogenism. Understanding the underlying mechanisms will help to better understand the pathology of PCOS and identify the new therapeutic goals of this syndrome. This review will focus on the possible effect of chemerin on the pathophysiology of PCOS.

Kaynakça

  • Kaynaklar Adrenal ve Gonadal Hastalıklar Çalışma Grubu. (2018). Adrenal ve Gonadal Hastalıklar Kılavuzu. Miki Matbaacılık San. Ltd. Şti. Ankara. Erişim adresi: http://www.temd.org.tr/admin/uploads/tbl_gruplar/20180517113623-2018-05 17tbl_gruplar113620.pdf Erişim tarihi: 10.03.2020. Aydoğdu, A,, Haymana, C., Tapan, S., Taşlıpınar, A., Yazıcı, M., Başaran, Y., Dinç, M., Sönmez, A., Azal, Ö. (2015). Polikistik over sendromu olgularında artmış visseral adipozite indeksi; inflamasyon, insülin direnci ve hiperandrojenite arasındaki ilişki. Gülhane Tıp Derg, 57(2), 107-110. Azziz, R. (2018). Polycystic Ovary Syndrome. Obstet Gynecol., 132(2), 321–336. doi:10.1097/AOG.0000000000002698 Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Futterweit, W, ve diğ. (2006). Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab, 91, 4237–4245. Blagojević, I.P., Ignjatović, S., Macut, D., Kotur-Stevuljević, J., Božić-Antić, I., Vekić, J. ve diğ. (2018). Evaluation of a Summary Score for Dyslipidemia, Oxidative Stress and Inflammation (the Doi Score) in Women with Polycystic Ovary Syndrome and its Relationship with Obesity. J Med Biochem., 37(4), 476–485. doi:10.2478/jomb-2018-00 Bódis, K., Roden, M. (2018). Energy metabolism of white adipose tissue and insulin resistance in humans. Eur J Clin Invest., 48(11), e13017. doi:10.1111/eci.13017 Bongrani, A., Mellouk, N., Rame, C., Cornuau, M., Guérif, F., Froment, P. ve diğ. (2019). Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction?. Int J Mol Sci., 20(15), E3778. doi: 10.3390/ijms20153778. Booth, A., Magnuson, A., Fouts, J., Foster, M.T. (2016). Adipose tissue: an endocrine organ playing a role in metabolic regulation. Horm Mol Biol Clin Investig., 26(1), 25–42. doi:10.1515/hmbci-2015-0073 Bozaoglu, K., Bolton, K., McMillan, J., Zimmet, P., Jowett, J., Collier, G. ve diğ. (2007). Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology., 148(10), 4687–4694. doi:10.1210/en.2007-0175 Bozdag, G., Mumusoglu, S., Zengin, D., Karabulut, E., Yildiz, B.O. (2016). The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction, 31(12), 2841-55. Brutocao, C., Zaiem, F., Alsawas, M., Morrow, A.S., Murad, M.H., Javed, A. (2018). Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine., 62(2), 318-325. doi: 10.1007/s12020-018-1692-3 Buechler, C., Feder, S., Haberl, E.M., Aslanidis, C. (2019). Chemerin Isoforms and Activity in Obesity. Int J Mol Sci., 20(5), 1128. doi:10.3390/ijms20051128 Chen, X., Jia, X., Qiao, J., Guan, Y., Kang, J. (2013). Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome. J Mol Endocrinol., 50(2), R21–R37..doi:10.1530/JME-12-0247. Cooke, P.S., Heine, P.A., Taylor, J.A., Lubahn, D.B. (2001). The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol Cell Endocrinol., 178(1-2), 147–154. doi:10.1016/s0303-7207(01)00414-2 Doğan, Ş.B., Ballı, U., Dede, F.Ö., Sertoğlu, E., Tazegül. K. (2016). Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus. J Periodontol., 87(8), 923–933. doi:10.1902/jop.2016.150657 Douglas. C.C., Gower. B.A., Darnell, B.E., Ovalle, F., Oster, R.A., Azziz, R. (2006). Role of diet in the treatment of polycystic ovary syndrome. Fertil Steril., 85(3), 679-88. Escobar-Morreale, H.F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol., 14(5), 270–284. doi:10.1038/nrendo.2018.24 Estienne, A., Bongrani, A., Reverchon, M., Ramé, C., Ducluzeau, P.H., Froment, P. ve diğ. (2019). Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models. Int J Mol Sci., 20(18), E4431. doi: 10.3390/ijms20184431. Fatima, S.S., Rehman, R., Baig, M., Khan, T.A. (2014). New roles of the multidimensional adipokine: chemerin. Peptides., 62, 15–20. doi:10.1016/j.peptides.2014.09.019 Foda, A.A., Foda, E.A., El-Negeri, M.A., El-Said, Z.H. (2019). Serum chemerin levels in Polycystic Ovary Syndrome after metformin therapy. Diabetes Metab Syndr., 13(2), 1309–1315. doi:10.1016/j.dsx.2019.01.050 Goralski, K.B., McCarthy, T.C., Hanniman, E.A., Zabel, B.A., Butcher, E.C., Parlee, S.D. ve diğ. (2007). Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem., 282(38); 28175-88. 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POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ

Yıl 2021, Cilt: 6 Sayı: 2, 197 - 210, 31.08.2021
https://doi.org/10.47115/jshs.752616

Öz

Polikistik over sendromu (PKOS), androjen fazlalığının (klinik veya biyokimyasal) ve over disfonksiyonunun (oligo-ovulasyon ve / veya polikistik over morfolojisi ) kombinasyonu ile tanımlanan heterojen bir hastalıktır. Polikistik over sendromunun etiyolojisi tam olarak bilinmemesine rağmen hiperandrojenizm, obezite (özellikle abdominal obezite), dislipidemi, kronik inflamasyon ve insülin direnci sendromun gelişiminde önemli bir etkiye sahiptir. Adipoz doku, özellikle beyaz adipoz doku, cinsiyet steroidlerinin etkisi altındadır, bu etki çok yönlü ve karmaşıktır. Adipoz doku androjen fazlalığına maruz kaldığında hipertrofiye eğilimlidir ve hem adipoz doku hipertrofisi hem de hiperandrojenizm, insülin direnciyle ilişkilidir. Adipoz doku bozukluğunun neden olduğu kronik düşük dereceli inflamasyonun da PKOS'un metabolik ve üreme bozukluklarının gelişiminde rol oynayabileceği gösterilmiştir. Büyük oranda beyaz adipoz dokudan salgılanan chemerin, yakın zamanda yeni bir kemoatraktan protein olarak adipokin ailesine katılmıştır. Chemerinin insan adipositlerinin farklılaşmasında, inflamasyon, glukoz ve lipit metabolizmasında önemli bir rol oynadığı çalışmalarda gösterilmiştir. Chemerinin, obezite ve insülin direnci ile ilişkilendirilmesi ayrıca adipoz dokuda kemoatraktan bir madde olarak inflamatuvar rolü sayesinde PKOS gelişimine katkıda bulunabileceği düşünülmektedir. Son yıllarda yapılan çalışmalarda PKOS’lu bireylerde serum chemerin konsantrasyonları sağlıklı bireylerle karşılaştırıldığında anlamlı olarak yüksek bulunmuş ve chemerin; beden kütle indeksi (BKİ), kan lipitleri, insülin direnci ve hiperandrojenizm ile ilişkilendirilmiştir. Altta yatan mekanizmaların anlaşılması PKOS patolojisini daha iyi anlamaya ve bu sendromun yeni terapötik hedeflerini tanımlamaya yardımcı olacaktır. Bu derlemede, PKOS patofizyolojisinde chemerinin olası etkileri üzerinde durulacaktır.

Kaynakça

  • Kaynaklar Adrenal ve Gonadal Hastalıklar Çalışma Grubu. (2018). Adrenal ve Gonadal Hastalıklar Kılavuzu. Miki Matbaacılık San. Ltd. Şti. Ankara. Erişim adresi: http://www.temd.org.tr/admin/uploads/tbl_gruplar/20180517113623-2018-05 17tbl_gruplar113620.pdf Erişim tarihi: 10.03.2020. Aydoğdu, A,, Haymana, C., Tapan, S., Taşlıpınar, A., Yazıcı, M., Başaran, Y., Dinç, M., Sönmez, A., Azal, Ö. (2015). Polikistik over sendromu olgularında artmış visseral adipozite indeksi; inflamasyon, insülin direnci ve hiperandrojenite arasındaki ilişki. Gülhane Tıp Derg, 57(2), 107-110. Azziz, R. (2018). Polycystic Ovary Syndrome. Obstet Gynecol., 132(2), 321–336. doi:10.1097/AOG.0000000000002698 Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Futterweit, W, ve diğ. (2006). Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab, 91, 4237–4245. Blagojević, I.P., Ignjatović, S., Macut, D., Kotur-Stevuljević, J., Božić-Antić, I., Vekić, J. ve diğ. (2018). Evaluation of a Summary Score for Dyslipidemia, Oxidative Stress and Inflammation (the Doi Score) in Women with Polycystic Ovary Syndrome and its Relationship with Obesity. J Med Biochem., 37(4), 476–485. doi:10.2478/jomb-2018-00 Bódis, K., Roden, M. (2018). Energy metabolism of white adipose tissue and insulin resistance in humans. Eur J Clin Invest., 48(11), e13017. doi:10.1111/eci.13017 Bongrani, A., Mellouk, N., Rame, C., Cornuau, M., Guérif, F., Froment, P. ve diğ. (2019). Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction?. Int J Mol Sci., 20(15), E3778. doi: 10.3390/ijms20153778. Booth, A., Magnuson, A., Fouts, J., Foster, M.T. (2016). Adipose tissue: an endocrine organ playing a role in metabolic regulation. Horm Mol Biol Clin Investig., 26(1), 25–42. doi:10.1515/hmbci-2015-0073 Bozaoglu, K., Bolton, K., McMillan, J., Zimmet, P., Jowett, J., Collier, G. ve diğ. (2007). Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology., 148(10), 4687–4694. doi:10.1210/en.2007-0175 Bozdag, G., Mumusoglu, S., Zengin, D., Karabulut, E., Yildiz, B.O. (2016). The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction, 31(12), 2841-55. Brutocao, C., Zaiem, F., Alsawas, M., Morrow, A.S., Murad, M.H., Javed, A. (2018). Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine., 62(2), 318-325. doi: 10.1007/s12020-018-1692-3 Buechler, C., Feder, S., Haberl, E.M., Aslanidis, C. (2019). Chemerin Isoforms and Activity in Obesity. Int J Mol Sci., 20(5), 1128. doi:10.3390/ijms20051128 Chen, X., Jia, X., Qiao, J., Guan, Y., Kang, J. (2013). Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome. J Mol Endocrinol., 50(2), R21–R37..doi:10.1530/JME-12-0247. Cooke, P.S., Heine, P.A., Taylor, J.A., Lubahn, D.B. (2001). The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol Cell Endocrinol., 178(1-2), 147–154. doi:10.1016/s0303-7207(01)00414-2 Doğan, Ş.B., Ballı, U., Dede, F.Ö., Sertoğlu, E., Tazegül. K. (2016). Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus. J Periodontol., 87(8), 923–933. doi:10.1902/jop.2016.150657 Douglas. C.C., Gower. B.A., Darnell, B.E., Ovalle, F., Oster, R.A., Azziz, R. (2006). Role of diet in the treatment of polycystic ovary syndrome. Fertil Steril., 85(3), 679-88. Escobar-Morreale, H.F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol., 14(5), 270–284. doi:10.1038/nrendo.2018.24 Estienne, A., Bongrani, A., Reverchon, M., Ramé, C., Ducluzeau, P.H., Froment, P. ve diğ. (2019). Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models. Int J Mol Sci., 20(18), E4431. doi: 10.3390/ijms20184431. Fatima, S.S., Rehman, R., Baig, M., Khan, T.A. (2014). New roles of the multidimensional adipokine: chemerin. Peptides., 62, 15–20. doi:10.1016/j.peptides.2014.09.019 Foda, A.A., Foda, E.A., El-Negeri, M.A., El-Said, Z.H. (2019). Serum chemerin levels in Polycystic Ovary Syndrome after metformin therapy. Diabetes Metab Syndr., 13(2), 1309–1315. doi:10.1016/j.dsx.2019.01.050 Goralski, K.B., McCarthy, T.C., Hanniman, E.A., Zabel, B.A., Butcher, E.C., Parlee, S.D. ve diğ. (2007). Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem., 282(38); 28175-88. 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Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Fatmanur Hümeyra Zengin

Efsun Karabudak 0000-0002-4210-1657

Yayımlanma Tarihi 31 Ağustos 2021
Gönderilme Tarihi 14 Haziran 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 6 Sayı: 2

Kaynak Göster

APA Zengin, F. H., & Karabudak, E. (2021). POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ. Samsun Sağlık Bilimleri Dergisi, 6(2), 197-210. https://doi.org/10.47115/jshs.752616
AMA Zengin FH, Karabudak E. POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ. JSHS. Ağustos 2021;6(2):197-210. doi:10.47115/jshs.752616
Chicago Zengin, Fatmanur Hümeyra, ve Efsun Karabudak. “POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ”. Samsun Sağlık Bilimleri Dergisi 6, sy. 2 (Ağustos 2021): 197-210. https://doi.org/10.47115/jshs.752616.
EndNote Zengin FH, Karabudak E (01 Ağustos 2021) POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ. Samsun Sağlık Bilimleri Dergisi 6 2 197–210.
IEEE F. H. Zengin ve E. Karabudak, “POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ”, JSHS, c. 6, sy. 2, ss. 197–210, 2021, doi: 10.47115/jshs.752616.
ISNAD Zengin, Fatmanur Hümeyra - Karabudak, Efsun. “POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ”. Samsun Sağlık Bilimleri Dergisi 6/2 (Ağustos 2021), 197-210. https://doi.org/10.47115/jshs.752616.
JAMA Zengin FH, Karabudak E. POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ. JSHS. 2021;6:197–210.
MLA Zengin, Fatmanur Hümeyra ve Efsun Karabudak. “POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ”. Samsun Sağlık Bilimleri Dergisi, c. 6, sy. 2, 2021, ss. 197-10, doi:10.47115/jshs.752616.
Vancouver Zengin FH, Karabudak E. POLİKİSTİK OVER SENDROMUNDA CHEMERİNİN ROLÜ. JSHS. 2021;6(2):197-210.

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