Olfaktör Bulbus Lezyonu ile İndüklenmiş Pineal Gland Kalsifikasyonu: İlk Deneysel Çalışma

Yıl 2024, , 32 - 37, 25.08.2024

Mehmet Kürşat Karadağ , Mehmet Aydin

https://doi.org/10.61745/jsmsau.1517053

Öz

Amaç: Pineal bez hastalıklarının nedenleri arasında maternal koku bozukluklarından ciddi şekilde bahseden yeterli stereolojik çalışma bulunmamaktadır. Bu çalışma, olfaktör bulbektominin neden olduğu lezyonlar ile sıçanlarda pineal bezdeki değişiklikler arasındaki bağlantıyı incelemeyi amaçlamıştır.
Yöntem: Bu çalışmada 5 kontrol, 6 Sham ve 13 çalışma olmak üzere toplam 24 erkek sıçan kullanıldı. Sham ve çalışma grupları için midfrontal-interpupiller çizgide 1 mm'lik bir burrhole açıldıktan sonra, Sham grubunda sadece olfaktor dura açıldı, çalışma grubunda ise olfaktor bulbuslar hasarlandırılmıştır. İki aylık takipten sonra sıçanlar öldürüldüler. Kalsifiye edilmiş pineal hücre sayısı (n/mm3) belirlendi. Sonuçlar Mann-Witney U testi ile analiz edildi.
Bulgular: Ortalama kalsifiye pineal hücre sayısı (n/mm3) milimetre küp başına şu şekilde ölçüldü: Kontrolde (Grup I) (7±2) x103/mm3); SHAM'da (Grup II) (15±3) x103); (34±9) x103 çalışma grubunda (Grup III). P<.005/(GI-GII); P<.0005/(GII-GIII); P<.00001/(GI-GIII).
Sonuç: Olfaktör bulbus lezyonu pineal bez kalsifikasyonundan sorumlu olabilir. Olfaktor bulbektomi sonucu pineal bezde oluşan patolojiler etiyolojisi tam olarak bilinmeyen çeşitli endokrin, immün ve üreme bozukluklarına yol açabilir.

Anahtar Kelimeler

Olfaktör bulbus lezyonu, pineal bez, kalsifikasyon

Olfactory Bulb Lesion Induced Pineal Gland Calcification: a First Experimental Study

Öz

Objectives: There is no enough stereological study that seriously mentions maternal olfactory disorders among the causes of pineal gland insults. This study sought to examine the connection between lesions caused by olfactory bulbectomy and changes in the pineal gland in rats
Methods: A total of 24 male rats were used in the experiment, 5 control, 6 SHAM and 13 study. After a 1 mm burrhole was opened in the midfrontal-interpupillary line for the subjects in the SHAM and study groups, only the olfactory dura was opened in the SHAM group, while the olfactory bulbs were crushed in study group. They were sacrificed after a two-month follow-up. The number of calcified pineal cells (n/mm3) determined. Results analyzed with the Mann-Witney U test.
Results: The mean calcified pineal cells numbers (n/mm3) were measured as per cubic milimeters as: (7±2) x103/mm3) in control (Group I); (15±3) x103 in SHAM (Group II); (34±9) x103 in study group (Group III). P<.005/(GI-GII); P<.0005/(GII-GIII); P<.00001/(GI-GIII).
Conclusions: Olfactory bulb lesion may be responsible for pineal gland calcification. Pathologies in the pineal gland resulting from olfactory bulbectomy may contribute to various endocrine, immune, and reproductive disorders with unclear etiologies.

Anahtar Kelimeler

Olfactory Bulb Lesion, Pineal Gland, Calcification

Kaynakça

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