The evaluation of migraine frequency in patients with psoriasis

Öz

Aim: Psoriasis, previously thought to be a disease restricted to the skin, is now considered systemic, accompanied by numerous comorbidities. Our study aimed to establish the migraine frequency in psoriasis patients and assess the relationship between the severity and duration of psoriasis and the frequency and severity of migraine. Materials and Methods: This case-control study was performed in the dermatology outpatient clinic. A total of 80 people, including 40 patients over the age of 18 who applied to the outpatient clinic and were diagnosed with psoriasis, and 40 people with similar gender and age characteristics and other skin problems, were included in the control group. Results: The frequency of migraine in psoriasis patients was 35.0% and 15.0% in the control group. In psoriasis patients, the median Psoriasis Area and Severity Index (PASI) score was 3.60 (1.20-13.20) in patients without migraine and 2.90 (1.20-12.00) in patients with migraine. Migraine frequency was 45.0% in patients suffering from the disease for more than eight years and 25.0% in patients suffering for eight years or less. The incidence of migraine was significantly higher in patients who had psoriasis for more than eight years than in the control group. Conclusion: Our study presented important outputs that the severity and duration of psoriasis disease might be related to migraine disease.

Anahtar Kelimeler

• psoriasis
• inflammation
• vascular
• migraine

Kaynakça

1. 1. Atakan N, Doğan S. Psoriazis Sistemik Bir Hastalık mıdır? Turk J Dermatol. 2012;6:119-122. https://doi.org/10.5152/tdd.2012.27
2. 2. Takeshita J, Grewal S, Langan SM, et al. Psoriasis and comorbid diseases: Epidemiology. J Am Acad Dermatol. 2017;76(3):377-390. https://doi.org/10.1016/J.JAAD.2016.07.064
3. 3. Yang YW, Keller JJ, Lin HC. Medical comorbidity associated with psoriasis in adults: a population-based study. Br J Dermatol. 2011;165(5):1037-1043. https://doi.org/10.1111/J.1365-2133.2011.10494.X
4. 4. Kim WB, Jerome D, Frcpc M, Yeung J. Clinical Review Diagnosis and management of psoriasis. Can Fam Physician. 2017;63:278-285. www.cfp.ca
5. 5. Hu SC, Lan CE. Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular Events, Cardiovascular Risk Factors and Implications for Treatment. Int J Mol Sci. 2017;18(10). https://doi.org/10.3390/IJMS18102211
6. 6. Amanat M, Salehi M, Rezaei N. Neurological and psychiatric disorders in psoriasis. Rev Neurosci. 2018;29(7):805-813. https://doi.org/10.1515/REVNEURO-2017-0108
7. 7. Boehncke WH, Schön MP. Psoriasis. Lancet (London, England). 2015;386(9997):983-994. https://doi.org/10.1016/S0140-6736(14)61909-7
8. 8. Akburak Ö. Dicle Üniversitesi Dermatoloji Polikliniğine Başvuran Psoriazis Tanılı Hastalarda Migren Görülme Sıklığının Araştırılması. Dicle Üniversitesi. 2018.

9. 9. MacGregor E A. Migraine. Ann Intern Med. 2017;166(7):ITC49-ITC64. https://doi.org/10.7326/AITC201704040
10. 10. Burch RC, Buse DC, Lipton RB. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37(4):631-649. https://doi.org/10.1016/J.NCL.2019.06.001
11. 11. Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, et al. Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally. Headache. 2006;46(2):200-207. https://doi.org/10.1111/J.1526-4610.2006.00337.X
12. 12. Capo A, Affaitati G, Giamberardino MA, Amerio P. Psoriasis and migraine. J Eur Acad Dermatology Venereol. 2018;32(1):57-61. https://doi.org/10.1111/jdv.14472
13. 13. Bonifati C, Berardesca E. Clinical outcome measures of psoriasis. Reumatismo. 2007;59 Suppl 1(SUPPL. 1):64-67. https://doi.org/10.4081/REUMATISMO.2007.1S.64
14. 14. Bilaç C, Şahin MT, Öztürkcan S. Dermatolojide hastalık şiddeti skorlama sistemleri. Turkderm-Arch Turk Dermatol Venerol. 2016;50:42-53. https://doi.org/10.4274/turkderm.67799
15. 15. Topal İO, Değirmentepe E, Cüre K, Kızıltaç U, Hökenek NB, Kocatürk E. Psoriasisli Hastaların Klinik ve Sosyodemografik Özelliklerinin Retrospektif Analizi. Okmeydanı Tıp Derg. 2017;33(4):199-205. https://doi.org/10.5222/otd.2017.07769
16. 16. Parisi R, Symmons D, Griffiths C, Ashcroft D. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133(2):377-385. https://doi.org/10.1038/JID.2012.339
17. 17. Chandra A, Ray A, Senapati S, Chatterjee R. Genetic and epigenetic basis of psoriasis pathogenesis. Mol Immunol. 2015;64(2):313-323. https://doi.org/10.1016/J.MOLIMM.2014.12.014
18. 18. Gudjonsson J, Elder J Psoriasis: epidemiology. Clin Dermatol. 2007;25(6):535-546. https://doi.org/10.1016/J.CLINDERMATOL.2007.08.007
19. 19. Tekin NS, Koca R, Altınyazar HC, Çınar S, Muhtar Ş, Aslaner NN. Zonguldak Bölgesindeki Psoriasis Hastalarının Sosyodemografik ve Klinik Özelliklerinin Değerlendirilmesi. Turkiye Klin J Dermatology. 2005;15(3):141-146. https://www.turkiyeklinikleri.com/article/en-zonguldak-bolgesindeki-psoriasis-hastalarinin-sosyodemografik-ve-klinik-ozelliklerinin-degerlendirilmesi-39738.html
20. 20. Turan H, Acer E, Aliaǧaoǧlu C, Uslu E, Albayrak H, Özşahin M. The evaluation of the sociodemografic and clinical features of patients with Psoriasis. Turk Dermatoloji Derg. 2013;7(2):76-80. https://doi.org/10.4274/tdd.1478
21. 21. Ferrándiz C, Pujol R, García-Patos V, Bordas X, Smandía J. Psoriasis of early and late onset: a clinical and epidemiologic study from Spain. J Am Acad Dermatol. 2002;46(6):867-873. https://doi.org/10.1067/MJD.2002.120470
22. 22. Armstrong A, Harskamp C, Armstrong E. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutr Diabetes. 2012;2(12). https://doi.org/10.1038/NUTD.2012.26
23. 23. Tanacan E, Karaosmanoglu N, Karaaslan E, Ek HM. Psoriazis şiddeti , vücut kitle indeksi ve bel çevresi arasındaki ilişkinin değerlendirilmesi. Ankara Eğt Arş Hast Derg. 2018;51(2):150-153.
24. 24. Gökçal E, Tamer S, Özet ÖK. Migrenli Kadınlarda Vücut Kitle İndeksinin Ağrı, Özürlülük ve Uyku Üzerine Etkileri. Van Med J. 2015;22(2):84-89.
25. 25. Min C, Lim H, Lim J-S, Sim S, Choi HG. Increased risk of migraine in patients with psoriasis. Medicine (Baltimore). 2019;98(17):e15370. https://doi.org/10.1097/md.0000000000015370
26. 26. Alpsoy E, Ergun T, Şendur N, eds. Tüm Yönleriyle PSORİASİS. TÜRK DERMA. Galenos Yayınevi; İstanbul, 2020.