Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer

Melike Şener Sorgun; Feray Aras; Cihan Göktan; Deniz Özel

Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer

Öz

Aim: To observe the change in apparent diffusion coefficient (ADC) value after chemoradiotherapy in lung cancer and to investigate the ability of the change in ADC values to detect response to treatment earlier than computed tomography (CT). Material and Methods: This prospective study was performed in patients with a confirmed diagnosis of stage III-IV lung cancer and included 25 patients who underwent T2-weighted MR, diffusionweighted images (DWI), CT, and FDG PET/CT. Thoracic diffusion MRI and CT examinations were performed on patients who received chemoradiotherapy. Post-therapy; Thoracic diffusion MRI was repeated one week after the two cycles of chemotherapy and two weeks after the end of the radiotherapy, while post-therapy CT was performed four or five weeks after therapy. Before and after treatment, ADCmin, ADCmean, and SUVmax values were compared with each other. Results: Data analysis revealed a statistically insignificant inverse correlation between the pre-therapy ADCmin and SUVmax (r=- 0.36; p=0.077) with ADCmean and SUVmax (r=-0.283; p=0.170). Post-therapy repeated measures revealed that increased ADCmin values were significantly higher with the tumor size change (r=- 0.872; p=0.000) and median size (r=-0.847; p=0.001) tumor on CT. Conclusion: ADC measurements with DWI may be a new prognostic marker in lung cancers predicting early response to chemotherapy in lung cancer.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Melike Şener Sorgun Bu kişi benim
Türkiye

Feray Aras Bu kişi benim
Türkiye

Cihan Göktan Bu kişi benim
Türkiye

Deniz Özel Bu kişi benim
Türkiye

Yayımlanma Tarihi

26 Nisan 2023

Gönderilme Tarihi

6 Ağustos 2022

Kabul Tarihi

27 Şubat 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 13 Sayı: 1

IZ

https://izlik.org/JA46TW46DZ

Kaynak Göster

RIS / Bibtex

APA

Şener Sorgun, M., Aras, F., Göktan, C., & Özel, D. (2023). Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer. Kafkas Journal of Medical Sciences, 13(1), 62-70. https://izlik.org/JA46TW46DZ

AMA

1.Şener Sorgun M, Aras F, Göktan C, Özel D. Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer. KAFKAS TIP BİL DERG. 2023;13(1):62-70. https://izlik.org/JA46TW46DZ

Chicago

Şener Sorgun, Melike, Feray Aras, Cihan Göktan, ve Deniz Özel. 2023. “Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer”. Kafkas Journal of Medical Sciences 13 (1): 62-70. https://izlik.org/JA46TW46DZ.

EndNote

Şener Sorgun M, Aras F, Göktan C, Özel D (01 Nisan 2023) Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer. Kafkas Journal of Medical Sciences 13 1 62–70.

IEEE

[1]M. Şener Sorgun, F. Aras, C. Göktan, ve D. Özel, “Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer”, KAFKAS TIP BİL DERG, c. 13, sy 1, ss. 62–70, Nis. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA46TW46DZ

ISNAD

Şener Sorgun, Melike - Aras, Feray - Göktan, Cihan - Özel, Deniz. “Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer”. Kafkas Journal of Medical Sciences 13/1 (01 Nisan 2023): 62-70. https://izlik.org/JA46TW46DZ.

JAMA

1.Şener Sorgun M, Aras F, Göktan C, Özel D. Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer. KAFKAS TIP BİL DERG. 2023;13:62–70.

MLA

Şener Sorgun, Melike, vd. “Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer”. Kafkas Journal of Medical Sciences, c. 13, sy 1, Nisan 2023, ss. 62-70, https://izlik.org/JA46TW46DZ.

Vancouver

1.Melike Şener Sorgun, Feray Aras, Cihan Göktan, Deniz Özel. Diffusion MR Imaging in Evaluation of Treatment Response in Patients with Lung Cancer. KAFKAS TIP BİL DERG [Internet]. 01 Nisan 2023;13(1):62-70. Erişim adresi: https://izlik.org/JA46TW46DZ