Breast Diseases and Myoma Uteri Co-Occurness

Öz

Aim: To evaluate the association between fibrocystic changes of the breast and myoma uteri of which have hormonal factors in their etiology. Material and Method: Between January 2017 to March 2017 a total of 665 consecutive women were retrospectively evaluated. One hundred and four patients having myoma uteri and 84 patients not having myoma uteri proved with imaging techniques, were included in the study. Mammographic breast density, and also whether there were mass, microcalcification, axillary lymphadenopathy or not, and mammographic BI-RADS results were enrolled. Besides, breast type, solid lesions, cysts, multiple cysts, ductal ectasia in ultrasonography and sonographic BI-RADS results were recorded. If it is available, the biopsy results were noted. Results: Mean age of myoma uteri group was 48.6±6.1 and control group was 50.0±8.7 and there was consistency in respect to ages. There was no significant difference in breast density, mass, microcalcification, ductal ectasia, and malignant lesions between the study and control group. Statistically, a significant difference was found in breast cysts between study (% 72.5) and control (% 51.9) group (p=0.008). Conclusion: Fibrocystic changes are more common in myoma uteri. It might be helpful in clinical practice to keep in mind this result in management of myoma uteri patients.

Anahtar Kelimeler

• ibrocystic changes; breast cycts; myoma uteri

Meme Hastalıkları Miyoma Uteri Birlikteliği

Öz

Amaç: Etiyolojisinde  hormonal faktörlerin suçlandığı memenin fibrokistik değişiklikleri ve miyoma uteri birlikteliğinin değerlendirilmesi amaçlanmıştır.

Materyal ve Metod: Ocak 2017-Mart 2017 tarihleri arasında toplam 655 ardışık kadın hasta geriye dönük tarandı. Görüntüleme bulguları ile miyoma uterisi olan 104 ve olmayan 84 hasta çalışmaya dahil edildi. Mamografide meme dansitesi ve ayrıca kitle, mikrokalsifikasyon, aksiller lenfadenopati bulunup bulunmaması, mamografi raporunun BI-RADS sonucu kaydedildi. Ayrıca hastaya ait meme ultrasonografisinde meme tipi, ultrasonografide solid lezyon, kist, multipl kist, duktal ektazi bulunup bulunmadığı ve BI-RADS sonucu değerlendirildi. Eğer mevcut ise biyopsi sonuçları da kaydedildi.

Bulgular: Miyoma uteri grubunda yaş ortalaması 48.6±6.1, kontrol grubunda 50.0±8.7 olup gruplar yaş bakımından uyumlu bulunmuştur. Çalışma ve kontrol grubunda meme dansiteleri, solid kitle, mikrokalsifikasyon, duktal ektazi vemalign lezyon sıklığı, açısından fark bulunmazken, kistler myoma uteri grubunda (%72.5) istatisitiksel olarak kontrol grubuna göre (%51.9) daha sık olarak bulunmuştur (p=0.008).

Sonuç: Miyoma uteride fibrokistik değişiklikler daha sık görülmektedir. Bu sonucun klinik pratikte miyoma uterili hastaların yönetiminde dikkate alınması faydalı olacaktır.

Anahtar Kelimeler

• fibrokistik değişiklikler,meme kistleri,miyoma uteri

Kaynakça

1. 1. Wu C1, Ray RM, Lin MG, Gao DL, Horner NK, Nelson ZC et al. A case-control study of risk factors for fibrocystic breast conditions: Shanghai Nutrition and Breast Disease Study, China, 1995-2000. Am J Epidemiol 2004; 160(10):945–60.
2. 2. Mannello F, Tonti GAM, Papa S. Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies. Breast Cancer Res Treat 2006;97(2):115–29.
3. 3. Talaei A, Moradi A, Rafiei F. The evaluation of the effect of metformin on breast fibrocystic disease. Breast Dis 2017;37(2):49–53.
4. 4. Gadducci A, Guerrieri ME, Genazzani AR. Benign breast diseases, contraception and hormone replacement therapy. Minerva Ginecol 2012 ;64(1):67–74.
5. 5. Azam S, Lange T, Huynh S, Aro AR, von Euler-Chelpin M, Vejborg I, et al. Hormone replacement therapy, mammographic density, and breast cancer risk: a cohort study. Cancer Causes Control 2018 Apr 18 (doi: 10.1007/s10552-018-1033-0)
6. 6. Parker WH. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril 2007;87(4):725–36.
7. 7. Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol 1990;94(4):435–8.
8. 8. Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 2003;111(8):1037–54.

9. 9. Yenen MC, Dede M, Goktolga U, Kuçuk T, Pabuçcu R. Hormone replacement therapy in postmenopausal women with benign fibrocystic mastopathy. Climacteric 2003;6(2):146–50.
10. 10. Mellissa YongCharlotte AtkinsonKatherine M. NewtonErin J. Aiello BowlesFrank Z. Stanczyk et al. Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women. Cancer Causes Control 2009;20(7):1039–53.
11. 11. Bertrand KA, Eliassen AH, Hankinson SE, Rosner BA, Tamimi RM. Circulating Hormones and Mammographic Density in Premenopausal Women. Horm Cancer 2018;9(2):117–27.
12. 12. Anil C, Guney T, Gursoy A. The prevalence of benign breast diseases in patients with nodular goiter and Hashimoto’s thyroiditis. J Endocrinol Invest 2015;38(9):971–5.
13. 13. Giustarini, E., Pinchera, A., Fierabracci, P., Roncella, M., Fustaino, L., Mammoli, C., et al. Thyroid autoimmunity in patients with malignant and benign breast diseases before surgery. European journal of endocrinology, 154(5), 645-649.
14. 14. Ozkaya, E., Cakir, E., Cinar, M., Kara, F., Baser, E., Cakir, C.,et al. (2012). Is hyperandrogenemia protective for fibrocystic breast disease in PCOS?. Gynecological Endocrinology, 28(6), 468-471.
15. 15. Vorherr H. Fibrocystic breast disease: pathophysiology, pathomorphology, clinical picture, and management. Am J Obstet Gynecol 1986;154(1):161–79.
16. 16. Habor V, Habor A, Copotoiu C, Panţîru A. Fibrocystic breast disease--breast cancer sequence. Chirurgia 2010;105(2):191–4.
17. 17. Meisner ALW, Houman Fekrazad M, Royce ME. Breast Disease: Benign and Malignant. Med Clin North Am 2008;92(5):1115–41.
18. 18. Audisio T, Crespo-Roca F, Giraudo P, Ramallo R. Fibroadenoma of the vulva- simultaneous with breast fibroadenomas and uterine myoma. J Low Genit Tract Dis. 2011;15(1):75-9.