Araştırma Makalesi
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Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio

Yıl 2022, Cilt: 12 Sayı: 3, 261 - 264, 15.12.2022

Öz

Aim: The relationship between mitral annular calcification (MAC) and atherosclerotic diseases is known. The CRP/albumin ratio (CAR) is one of the indicators of inflammation of the atherosclerotic process. We aim to examine the relationship between MAC and CAR values.
Material and Method: The study included 197 patients with MAC and a control group of 200 retrospectively between January 2021 and December 2021. We analyzed the relationship between CAR and MAC according to the hospital records, including laboratory findings, echocardiography reports, and patient characteristics.
Results: We found higher CAR values in patients with MAC compared to the control group (p<0.001). In addition, CAR was predictive for MAC determined by regression analysis (OR: 52.37, 95% CI: 7.37–372.06, p<0.001).
Conclusion: CRP/albumin ratio values, essential indicators of inflammation, were higher in the patient population with MAC. This finding may reveal that inflammation is also effective in the pathogenesis of MAC.

Kaynakça

  • 1. Roberts WC, Perloff JK. Mitral valvular disease. A clinicopathologic survey of the conditions causing the mitral valve to function abnormally. Ann Intern Med. 1972;77(6):93975. doi:10.7326/0003-4819-77-6-939
  • 2. Carpentier AF, Pellerin M, Fuzellier JF, Relland JY. Extensive calcification of the mitral valve anulus: pathology and surgical management. J Thorac Cardiovasc Surg. 1996;111(4):718–30. doi:10.1016/s0022-5223(96)70332-x
  • 3. Adler Y, Fink N, Spector D, Wiser I, Sagie A. Mitral annulus calcification--a window to diffuse atherosclerosis of the vascular system. Atherosclerosis. 2001;155(1):1–8. doi:10.1016/s00219150(00)00737-1
  • 4. Roberts WC. The senile cardiac calcification syndrome. Am J Cardiol. 1986;58(6):572–4. doi:10.1016/00029149(86)90045-7
  • 5. Shekar C, Budoff M. Calcification of the heart: mechanisms and therapeutic avenues. Expert Rev Cardiovasc Ther. 2018;16(7):527–36. doi:10.1080/14779072.2018.1484282
  • 6. Afshar M, Luk K, Do R, et al. Association of TriglycerideRelated Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol. 2017;69(24):2941–8. doi:10.1016/j. jacc.2017.04.051
  • 7. Freeman RV, Otto CM. Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation. 2005;111(24):3316–26. doi:10.1161/ CIRCULATIONAHA.104.486738
  • 8. Rencuzogullari I, Karabağ Y, Çağdaş M, et al. Assessment of the relationship between preprocedural C-reactive protein/albumin ratio and stent restenosis in patients with ST-segment elevation myocardial infarction. Rev Port Cardiol. 2019;38(4):269–77. doi:10.1016/j.repc.2018.08.008
  • 9. Çağdaş M, Rencüzoğullari I, Karakoyun S, et al. Assessment of Relationship Between C-Reactive Protein to Albumin Ratio and Coronary Artery Disease Severity in Patients With Acute Coronary Syndrome. Angiology. 2019;70(4):361–8. doi:10.1177/0003319717743325
  • 10. Wang W, Ren D, Wang C-S, Li T, Yao H-C, Ma S-J. Prognostic efficacy of high-sensitivity C-reactive protein to albumin ratio in patients with acute coronary syndrome. Biomark Med. 2019;13(10):811–20. doi:10.2217/bmm-2018-0346
  • 11. Rezaeian P, Miller PE, Haberlen SA, et al. Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men: Multicenter AIDS Cohort Study. J Cardiovasc Comput Tomogr. 2016;10(3):229–36. doi:10.1016/j.jcct.2016.02.002
  • 12. Bortnick AE, Bartz TM, Ix JH, et al. Association of inflammatory, lipid and mineral markers with cardiac calcification in older adults. Heart. 2016;102(22):1826–34. doi:10.1136/heartjnl-2016–309404
  • 13. Fox CS, Guo C-Y, Larson MG, et al. Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol. 2006;97(10):1502–5. doi:10.1016/j.amjcard.2005.11.086
  • 14. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J. 2018;39(33):3021–104. doi:10.1093/eurheartj/ehy339
  • 15. Association AD. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021. Diabetes Care. 2020;44(Supplement_1):S15–33. doi:10.2337/dc21-S002
  • 16. Nair CK, Thomson W, Ryschon K, Cook C, Hee TT, Sketch MH. Long-term follow-up of patients with echocardiographically detected mitral anular calcium and comparison with age- and sex-matched control subjects. Am J Cardiol. 1989;63(7):46570. doi:10.1016/0002-9149(89)90321-4
  • 17. Guler S, Varol E. The relation between echocardiographic epicardial fat thickness and mitral annular calcification. Afr Health Sci. 2019;19(1):1657–64. doi:10.4314/ahs.v19i1.41
  • 18. Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013;368(6):503–12. doi:10.1056/NEJMoa1109034
  • 19. Thanassoulis G, Massaro JM, Cury R, et al. Associations of longterm and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J Am Coll Cardiol. 2010;55(22):2491–8. doi:10.1016/j.jacc.2010.03.019
  • 20. Yayla Ç, Akboğa MK, Canpolat U, et al. [The relationship between mitral annular calcification and red cell distribution width: a cross-sectional study]. Turk Kardiyol Dern Ars. 2015;43(8):692–8. doi:10.5543/tkda.2015.23539
  • 21. Ardahanli I, Cengizhan MS, Celik M, Kader S, Akarslan M, Takir M. Carotid artery intima-media thickness and heart valve calcifications in hemodialysis patients with hyperparathyroidism (A Pilot Study). Arch Nephrol Urol. 2019;2(2):52–61.
  • 22. Karabağ Y, Çağdaş M, Rencuzogullari I, et al. Usefulness of T he C-Reactive Protein/Albumin Ratio for Predicting NoReflow in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Eur J Clin Invest. 2018;48(6):e12928. doi:10.1111/eci.12928
  • 23. Torzewski M, Rist C, Mortensen RF, et al. C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb Vasc Biol. 2000;20(9):2094–9. doi:10.1161/01.atv.20.9.2094
  • 24. Torzewski J, Torzewski M, Bowyer DE, et al. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol. 1998;18(9):1386–92. doi:10.1161/01.atv.18.9.1386
  • 25. Taskinen S, Kovanen PT, Jarva H, Meri S, Pentikäinen MO. Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein. Biochem J. 2002;367(Pt 2):403–12. doi:10.1042/BJ20020492
  • 26. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102(18):2165–8. doi:10.1161/01.cir.102.18.2165
  • 27. Mikhailidis DP, Ganotakis ES. Plasma albumin and platelet function: relevance to atherogenesis and thrombosis. Platelets. 1996;7(3):125–37. doi:10.3109/09537109609023571
Yıl 2022, Cilt: 12 Sayı: 3, 261 - 264, 15.12.2022

Öz

Kaynakça

  • 1. Roberts WC, Perloff JK. Mitral valvular disease. A clinicopathologic survey of the conditions causing the mitral valve to function abnormally. Ann Intern Med. 1972;77(6):93975. doi:10.7326/0003-4819-77-6-939
  • 2. Carpentier AF, Pellerin M, Fuzellier JF, Relland JY. Extensive calcification of the mitral valve anulus: pathology and surgical management. J Thorac Cardiovasc Surg. 1996;111(4):718–30. doi:10.1016/s0022-5223(96)70332-x
  • 3. Adler Y, Fink N, Spector D, Wiser I, Sagie A. Mitral annulus calcification--a window to diffuse atherosclerosis of the vascular system. Atherosclerosis. 2001;155(1):1–8. doi:10.1016/s00219150(00)00737-1
  • 4. Roberts WC. The senile cardiac calcification syndrome. Am J Cardiol. 1986;58(6):572–4. doi:10.1016/00029149(86)90045-7
  • 5. Shekar C, Budoff M. Calcification of the heart: mechanisms and therapeutic avenues. Expert Rev Cardiovasc Ther. 2018;16(7):527–36. doi:10.1080/14779072.2018.1484282
  • 6. Afshar M, Luk K, Do R, et al. Association of TriglycerideRelated Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol. 2017;69(24):2941–8. doi:10.1016/j. jacc.2017.04.051
  • 7. Freeman RV, Otto CM. Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation. 2005;111(24):3316–26. doi:10.1161/ CIRCULATIONAHA.104.486738
  • 8. Rencuzogullari I, Karabağ Y, Çağdaş M, et al. Assessment of the relationship between preprocedural C-reactive protein/albumin ratio and stent restenosis in patients with ST-segment elevation myocardial infarction. Rev Port Cardiol. 2019;38(4):269–77. doi:10.1016/j.repc.2018.08.008
  • 9. Çağdaş M, Rencüzoğullari I, Karakoyun S, et al. Assessment of Relationship Between C-Reactive Protein to Albumin Ratio and Coronary Artery Disease Severity in Patients With Acute Coronary Syndrome. Angiology. 2019;70(4):361–8. doi:10.1177/0003319717743325
  • 10. Wang W, Ren D, Wang C-S, Li T, Yao H-C, Ma S-J. Prognostic efficacy of high-sensitivity C-reactive protein to albumin ratio in patients with acute coronary syndrome. Biomark Med. 2019;13(10):811–20. doi:10.2217/bmm-2018-0346
  • 11. Rezaeian P, Miller PE, Haberlen SA, et al. Extra-coronary calcification (aortic valve calcification, mitral annular calcification, aortic valve ring calcification and thoracic aortic calcification) in HIV seropositive and seronegative men: Multicenter AIDS Cohort Study. J Cardiovasc Comput Tomogr. 2016;10(3):229–36. doi:10.1016/j.jcct.2016.02.002
  • 12. Bortnick AE, Bartz TM, Ix JH, et al. Association of inflammatory, lipid and mineral markers with cardiac calcification in older adults. Heart. 2016;102(22):1826–34. doi:10.1136/heartjnl-2016–309404
  • 13. Fox CS, Guo C-Y, Larson MG, et al. Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol. 2006;97(10):1502–5. doi:10.1016/j.amjcard.2005.11.086
  • 14. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J. 2018;39(33):3021–104. doi:10.1093/eurheartj/ehy339
  • 15. Association AD. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021. Diabetes Care. 2020;44(Supplement_1):S15–33. doi:10.2337/dc21-S002
  • 16. Nair CK, Thomson W, Ryschon K, Cook C, Hee TT, Sketch MH. Long-term follow-up of patients with echocardiographically detected mitral anular calcium and comparison with age- and sex-matched control subjects. Am J Cardiol. 1989;63(7):46570. doi:10.1016/0002-9149(89)90321-4
  • 17. Guler S, Varol E. The relation between echocardiographic epicardial fat thickness and mitral annular calcification. Afr Health Sci. 2019;19(1):1657–64. doi:10.4314/ahs.v19i1.41
  • 18. Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013;368(6):503–12. doi:10.1056/NEJMoa1109034
  • 19. Thanassoulis G, Massaro JM, Cury R, et al. Associations of longterm and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J Am Coll Cardiol. 2010;55(22):2491–8. doi:10.1016/j.jacc.2010.03.019
  • 20. Yayla Ç, Akboğa MK, Canpolat U, et al. [The relationship between mitral annular calcification and red cell distribution width: a cross-sectional study]. Turk Kardiyol Dern Ars. 2015;43(8):692–8. doi:10.5543/tkda.2015.23539
  • 21. Ardahanli I, Cengizhan MS, Celik M, Kader S, Akarslan M, Takir M. Carotid artery intima-media thickness and heart valve calcifications in hemodialysis patients with hyperparathyroidism (A Pilot Study). Arch Nephrol Urol. 2019;2(2):52–61.
  • 22. Karabağ Y, Çağdaş M, Rencuzogullari I, et al. Usefulness of T he C-Reactive Protein/Albumin Ratio for Predicting NoReflow in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Eur J Clin Invest. 2018;48(6):e12928. doi:10.1111/eci.12928
  • 23. Torzewski M, Rist C, Mortensen RF, et al. C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb Vasc Biol. 2000;20(9):2094–9. doi:10.1161/01.atv.20.9.2094
  • 24. Torzewski J, Torzewski M, Bowyer DE, et al. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol. 1998;18(9):1386–92. doi:10.1161/01.atv.18.9.1386
  • 25. Taskinen S, Kovanen PT, Jarva H, Meri S, Pentikäinen MO. Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein. Biochem J. 2002;367(Pt 2):403–12. doi:10.1042/BJ20020492
  • 26. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000;102(18):2165–8. doi:10.1161/01.cir.102.18.2165
  • 27. Mikhailidis DP, Ganotakis ES. Plasma albumin and platelet function: relevance to atherogenesis and thrombosis. Platelets. 1996;7(3):125–37. doi:10.3109/09537109609023571
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Kürşat Akbuğa Bu kişi benim

Hatice Kayıkcıoğlu Bu kişi benim

Yayımlanma Tarihi 15 Aralık 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 12 Sayı: 3

Kaynak Göster

APA Akbuğa, K., & Kayıkcıoğlu, H. (2022). Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio. Kafkas Journal of Medical Sciences, 12(3), 261-264.
AMA Akbuğa K, Kayıkcıoğlu H. Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio. KAFKAS TIP BİL DERG. Aralık 2022;12(3):261-264.
Chicago Akbuğa, Kürşat, ve Hatice Kayıkcıoğlu. “Evaluation of the Relationship Between Mitral Annular Calcification and CRP/Albumin Ratio”. Kafkas Journal of Medical Sciences 12, sy. 3 (Aralık 2022): 261-64.
EndNote Akbuğa K, Kayıkcıoğlu H (01 Aralık 2022) Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio. Kafkas Journal of Medical Sciences 12 3 261–264.
IEEE K. Akbuğa ve H. Kayıkcıoğlu, “Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio”, KAFKAS TIP BİL DERG, c. 12, sy. 3, ss. 261–264, 2022.
ISNAD Akbuğa, Kürşat - Kayıkcıoğlu, Hatice. “Evaluation of the Relationship Between Mitral Annular Calcification and CRP/Albumin Ratio”. Kafkas Journal of Medical Sciences 12/3 (Aralık 2022), 261-264.
JAMA Akbuğa K, Kayıkcıoğlu H. Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio. KAFKAS TIP BİL DERG. 2022;12:261–264.
MLA Akbuğa, Kürşat ve Hatice Kayıkcıoğlu. “Evaluation of the Relationship Between Mitral Annular Calcification and CRP/Albumin Ratio”. Kafkas Journal of Medical Sciences, c. 12, sy. 3, 2022, ss. 261-4.
Vancouver Akbuğa K, Kayıkcıoğlu H. Evaluation of the Relationship Between Mitral Annular Calcification and CRP/albumin Ratio. KAFKAS TIP BİL DERG. 2022;12(3):261-4.