Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2024, Cilt: 14 Sayı: 3, 207 - 211, 31.12.2024

Öz

Kaynakça

  • 1. Özlü T, Zorlu D. Current Threat: Novel Coronavirus Disease (-19) and Turkey Experience. ASYOD Current Chest Diseases Series Books. Ed: Karadağ M, et al. World Medical Bookstore. Ankara. 2021;26–33.
  • 2. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio. 2012;3(6):e00473–12.
  • 3. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses [Internet]. 2020;12(4):372.
  • 4. Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465–469.
  • 5. Hui KPY, Cheung MC, Perera RAPM, Ng KC, Bui CHT, Ho JCW. et al. Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in the human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures. Lancet Respir Med. 2020;8(7):687–695.
  • 6. Dinç F, Appak Ö, Sayıner A. COVID-19 microbiological diagnostic tests. Journal of Dokuz Eylul University Faculty of Medicine. 2021;35(Special Issue 1):55–69.
  • 7. European Centre for Disease Prevention and Control [Internet]. Options for the use of rapid antigen tests for COVID‐19 in the EU/EEA and the UK 19 November 2020 https://www. ecdc. europa. eu/sites/default/files/docum ents/Options‐use‐of‐rapid‐antigen‐tests‐for‐COVID‐ 19_0. pdf
  • 8. Centers for Disease Control and Prevention interim guidelines [Internet]. Using Antibody Tests for COVID‐19 https://www. cdc. gov/coronavirus/2019‐ ncov/lab/resources/antibody‐tests‐guidelines.
  • 9. Arabacı Ç, Aydın Tutak G, Eroğlu Kesim B, Ertürk B, Ak K, Ağaç E. The Characteristics of SARSCoV-2 Virus and Microbiological Diagnosis. Eur Arch Med Res. 2020;36(Suppl 1):10–20.
  • 10. World Health Organization Antigen-Detection in the Diagnosis of SARS-CoV-2 Infection Using Rapid Immunoassays: Interim Guidance Available online: https://www. who. int/publications/i/item/antigen-detection-in-the-diagnosis-of-sars-cov-2infection-using-rapid-immunoassays
  • 11. İskit AT, Tanrıöver MD, COVID-19 Pandemic Report (20 March-20 November 2020); Hacettepe Internal Medicine Association Ankara, Türkiye; p. 41. http://hdl. handle. net/11655/23314.
  • 12. Li J, Ye G, Chen L, Wang J, Li Y. Analysis of false‐ negative results for 2019 novel coronavirus nucleic acid test and related countermeasures. Chinese J Laborat Med. 2020;43:E006.
  • 13. Watson J, Whiting PF, Brush JE. Interpreting a -19 test result. BMJ. 2020;369:m1808. Published 2020 May 12.
  • 14. Chaimayo C, Kaewnaphan B, Tanlieng N, Athipanyasilp N, Sirijatuphat R, Chayakulkeeree M, et al. Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J. 2020;17(1):177.
  • 15. Torres I, Poujois S, Albert E, Álvarez G, Colomina J, Navarro D. Point-of-care evaluation of a rapid antigen test (CLINITEST® Rapid COVID-19 Antigen Test) for diagnosis of SARS-CoV-2 infection in symptomatic and asymptomatic individuals. J Infect. 2021;82(5):e11–e12.
  • 16. Diao B, Wen K, Zhang J, Chen J, Han C, Chen Y, et al. Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection. Clin Microbiol Infect. 2021;27(2):289. e1–289. e4.
  • 17. Ciotti M, Maurici M, Pieri M, Andreoni M, Bernardini S. Performance of a rapid antigen test in the diagnosis of SARS-CoV-2 infection. J Med Virol. 2021;93(5):2988–91.
  • 18. Krüttgen A, Cornelissen CG, Dreher M, Hornef MW, Imöhl M, Kleines M. Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit. J Virol Methods. 2021;288:114024.
  • 19. Chiu RYT, Kojima N, Mosley GL, Cheng KK, Pereira DY, Brobeck M, et al. Evaluation of the INDICAID COVID-19 Rapid Antigen Test in Symptomatic Populations and Asymptomatic Community Testing. Microbiol Spectr. 2021;9(1):e0034221.
  • 20. Jaaskelainen AE, Ahava MJ, Jokela P, Szirovicza L, Pohjala S, Vapalahti O, et al. Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection. J Clin Virol. 2021;137:104785.

Rapid Antigen Test in the Diagnosis of COVID-19

Yıl 2024, Cilt: 14 Sayı: 3, 207 - 211, 31.12.2024

Öz

Aim: The COVID-19 pandemic has shown the importance of laboratory-based diagnosis in the control of infectious diseases. Early and accurate diagnosis of COVID-19 is crucial for limiting the spread of infection and determining the treatment to be applied to patients. Our study compared the results of real-time polymerase chain reaction (RT-PCR) and rapid antigen tests to diagnose COVID-19.
Material and Method: Nasal and throat swab samples sent from 500 patients to our laboratory were studied by RT-PCR method with Multiplex RT-qPCR Diagnostic Kit 1000 rxn (CORONEX, Türkiye) and by Abbot COVID-19 Ag Rapid Test Device (Germany) immunochromotographic method by the recommendations of the manufacturer companies. The patient’s Demographic information in the study was taken from the hospital information automation system.
Results: Of the 500 patients participating in the study, 202 (40.4%) were women, and 298 (59.6%) were men. While 57 patients (11.4%) were detected positively by the RT-PCR method, 54(10.4%) were detected positively by a rapid antigen test method. Of the 57 patients found positive by the RT-PCR method, 8 (14%) were negative by a rapid antigen test method. Of the 54 patients found positive by the rapid antigen test method, 5 (9.25%) were negative by the RT-PCR method. According to the RT-PCR method, the sensitivity of the rapid antigen test test was 90.74%, and the specificity was 98.21%.
Conclusion: Although the RT-PCR test is the gold standard method for COVID-19 detection, rapid antigen tests may be useful as a screening test or as a supportive test in diagnosis during periods of intense virus activity or epidemic situations.

Kaynakça

  • 1. Özlü T, Zorlu D. Current Threat: Novel Coronavirus Disease (-19) and Turkey Experience. ASYOD Current Chest Diseases Series Books. Ed: Karadağ M, et al. World Medical Bookstore. Ankara. 2021;26–33.
  • 2. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio. 2012;3(6):e00473–12.
  • 3. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses [Internet]. 2020;12(4):372.
  • 4. Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465–469.
  • 5. Hui KPY, Cheung MC, Perera RAPM, Ng KC, Bui CHT, Ho JCW. et al. Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in the human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures. Lancet Respir Med. 2020;8(7):687–695.
  • 6. Dinç F, Appak Ö, Sayıner A. COVID-19 microbiological diagnostic tests. Journal of Dokuz Eylul University Faculty of Medicine. 2021;35(Special Issue 1):55–69.
  • 7. European Centre for Disease Prevention and Control [Internet]. Options for the use of rapid antigen tests for COVID‐19 in the EU/EEA and the UK 19 November 2020 https://www. ecdc. europa. eu/sites/default/files/docum ents/Options‐use‐of‐rapid‐antigen‐tests‐for‐COVID‐ 19_0. pdf
  • 8. Centers for Disease Control and Prevention interim guidelines [Internet]. Using Antibody Tests for COVID‐19 https://www. cdc. gov/coronavirus/2019‐ ncov/lab/resources/antibody‐tests‐guidelines.
  • 9. Arabacı Ç, Aydın Tutak G, Eroğlu Kesim B, Ertürk B, Ak K, Ağaç E. The Characteristics of SARSCoV-2 Virus and Microbiological Diagnosis. Eur Arch Med Res. 2020;36(Suppl 1):10–20.
  • 10. World Health Organization Antigen-Detection in the Diagnosis of SARS-CoV-2 Infection Using Rapid Immunoassays: Interim Guidance Available online: https://www. who. int/publications/i/item/antigen-detection-in-the-diagnosis-of-sars-cov-2infection-using-rapid-immunoassays
  • 11. İskit AT, Tanrıöver MD, COVID-19 Pandemic Report (20 March-20 November 2020); Hacettepe Internal Medicine Association Ankara, Türkiye; p. 41. http://hdl. handle. net/11655/23314.
  • 12. Li J, Ye G, Chen L, Wang J, Li Y. Analysis of false‐ negative results for 2019 novel coronavirus nucleic acid test and related countermeasures. Chinese J Laborat Med. 2020;43:E006.
  • 13. Watson J, Whiting PF, Brush JE. Interpreting a -19 test result. BMJ. 2020;369:m1808. Published 2020 May 12.
  • 14. Chaimayo C, Kaewnaphan B, Tanlieng N, Athipanyasilp N, Sirijatuphat R, Chayakulkeeree M, et al. Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J. 2020;17(1):177.
  • 15. Torres I, Poujois S, Albert E, Álvarez G, Colomina J, Navarro D. Point-of-care evaluation of a rapid antigen test (CLINITEST® Rapid COVID-19 Antigen Test) for diagnosis of SARS-CoV-2 infection in symptomatic and asymptomatic individuals. J Infect. 2021;82(5):e11–e12.
  • 16. Diao B, Wen K, Zhang J, Chen J, Han C, Chen Y, et al. Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection. Clin Microbiol Infect. 2021;27(2):289. e1–289. e4.
  • 17. Ciotti M, Maurici M, Pieri M, Andreoni M, Bernardini S. Performance of a rapid antigen test in the diagnosis of SARS-CoV-2 infection. J Med Virol. 2021;93(5):2988–91.
  • 18. Krüttgen A, Cornelissen CG, Dreher M, Hornef MW, Imöhl M, Kleines M. Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit. J Virol Methods. 2021;288:114024.
  • 19. Chiu RYT, Kojima N, Mosley GL, Cheng KK, Pereira DY, Brobeck M, et al. Evaluation of the INDICAID COVID-19 Rapid Antigen Test in Symptomatic Populations and Asymptomatic Community Testing. Microbiol Spectr. 2021;9(1):e0034221.
  • 20. Jaaskelainen AE, Ahava MJ, Jokela P, Szirovicza L, Pohjala S, Vapalahti O, et al. Evaluation of three rapid lateral flow antigen detection tests for the diagnosis of SARS-CoV-2 infection. J Clin Virol. 2021;137:104785.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Feray Ferda Şenol

Altay Babacan

Mete Özcan

Esra Timurkaan

Yüksel Akaya Bu kişi benim

Özlem Aytaç Bu kişi benim

Pınar Öner Bu kişi benim

Zülal Aşçı Toraman

Yayımlanma Tarihi 31 Aralık 2024
Gönderilme Tarihi 6 Kasım 2023
Kabul Tarihi 15 Ağustos 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 14 Sayı: 3

Kaynak Göster

APA Şenol, F. F., Babacan, A., Özcan, M., Timurkaan, E., vd. (2024). Rapid Antigen Test in the Diagnosis of COVID-19. Kafkas Journal of Medical Sciences, 14(3), 207-211.
AMA Şenol FF, Babacan A, Özcan M, Timurkaan E, Akaya Y, Aytaç Ö, Öner P, Aşçı Toraman Z. Rapid Antigen Test in the Diagnosis of COVID-19. KAFKAS TIP BİL DERG. Aralık 2024;14(3):207-211.
Chicago Şenol, Feray Ferda, Altay Babacan, Mete Özcan, Esra Timurkaan, Yüksel Akaya, Özlem Aytaç, Pınar Öner, ve Zülal Aşçı Toraman. “Rapid Antigen Test in the Diagnosis of COVID-19”. Kafkas Journal of Medical Sciences 14, sy. 3 (Aralık 2024): 207-11.
EndNote Şenol FF, Babacan A, Özcan M, Timurkaan E, Akaya Y, Aytaç Ö, Öner P, Aşçı Toraman Z (01 Aralık 2024) Rapid Antigen Test in the Diagnosis of COVID-19. Kafkas Journal of Medical Sciences 14 3 207–211.
IEEE F. F. Şenol, A. Babacan, M. Özcan, E. Timurkaan, Y. Akaya, Ö. Aytaç, P. Öner, ve Z. Aşçı Toraman, “Rapid Antigen Test in the Diagnosis of COVID-19”, KAFKAS TIP BİL DERG, c. 14, sy. 3, ss. 207–211, 2024.
ISNAD Şenol, Feray Ferda vd. “Rapid Antigen Test in the Diagnosis of COVID-19”. Kafkas Journal of Medical Sciences 14/3 (Aralık 2024), 207-211.
JAMA Şenol FF, Babacan A, Özcan M, Timurkaan E, Akaya Y, Aytaç Ö, Öner P, Aşçı Toraman Z. Rapid Antigen Test in the Diagnosis of COVID-19. KAFKAS TIP BİL DERG. 2024;14:207–211.
MLA Şenol, Feray Ferda vd. “Rapid Antigen Test in the Diagnosis of COVID-19”. Kafkas Journal of Medical Sciences, c. 14, sy. 3, 2024, ss. 207-11.
Vancouver Şenol FF, Babacan A, Özcan M, Timurkaan E, Akaya Y, Aytaç Ö, Öner P, Aşçı Toraman Z. Rapid Antigen Test in the Diagnosis of COVID-19. KAFKAS TIP BİL DERG. 2024;14(3):207-11.