Araştırma Makalesi
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Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity

Yıl 2025, Cilt: 15 Sayı: 2, 208 - 213, 31.08.2025

Öz

Aim: The incidence of gastrointestinal cancers has shifted to older age groups with global population aging. Elderly patients often present with diminished reserves and comorbidities, necessitating individualized risk assessment. This study aimed to evaluate preoperative risk assessment tools, including the Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), American Society of Anesthesiologists (ASA) score, and Eastern Cooperative Oncology Group Performance Status (ECOG-PS), in predicting early postoperative outcomes in elderly patients undergoing curative gastrointestinal cancer surgery.
Material and Methods: This retrospective study included patients aged ≥75 years (n=65) and 50–65 years (n=60) who underwent curative surgery between 2019 and 2023. Comorbidities, ASA scores, ECOG-PS, POSSUM scores, postoperative complications, and early mortality were analyzed.
Results: Elderly patients had significantly higher comorbidity rates, ASA, ECOG-PS, and POSSUM scores. Although early mortality and ICU stays were more frequent in elderly patients, multivariate analysis did not identify age ≥75 as an independent risk factor. The ASA score was significantly associated with postoperative morbidity (OR: 3.2, 95%CI: 1.5–6.7), whereas POSSUM and ECOG-PS scores were not predictive of early mortality.
Conclusion: Age alone is not an independent predictor of postoperative outcomes. Higher ASA scores are strongly associated with morbidity, emphasizing the need for comprehensive preoperative assessments.

Kaynakça

  • 1. Schlesinger-Raab A, Werner J, Friess H, Hölzel D, Engel J. Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer. Visc Med. 2017;33:245–53.
  • 2. Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (20082030): a population-based study. Lancet Oncol. 2012;13:790801.
  • 3. Millan M, Merino S, Caro A, Feliu F, Escuder J, Francesch T. Treatment of colorectal cancer in the elderly. World J Gastrointest Oncol. 2015;7:204.
  • 4. Extermann M, Hurria A. Comprehensive Geriatric Assessment for Older Patients With Cancer. Journal of Clinical Oncology. 2007;25:1824–31.
  • 5. Thiels CA, Bergquist JR, Meyers AJ, Johnson CL, Behm KT, Hayman A V, et al. Outcomes with multimodal therapy for elderly patients with rectal cancer. Journal of British Surgery. 2016;103:e106–14.
  • 6. Fentiman I. Treatment of cancer in the elderly. Br J Cancer. 1991;64:993–5.
  • 7. Audisio RA, Veronesi P, Ferrario L, Cipolla C, Andreoni B, Aapro M. Elective surgery for gastrointestinal tumours in the elderly. Annals of Oncology. 1997;8:317–26.
  • 8. Alexander HR, Turnbull AD, Salamone J, Keefe D, Melendez J. Upper abdominal cancer surgery in the very elderly. J Surg Oncol. 1991;47:82–6.
  • 9. Welch CS. Surgery in the Aged. New England Journal of Medicine. 1948;238:821–32.
  • 10. Yeager MP, Glass DD, Neff RK, Brinck-Johnsen T. Epidural Anesthesia and Analgesia in High-risk Surgical Patients. Anesthesiology. 1987;66:729–36.
  • 11. Li Q, Lu Y. Predictive value of POSSUM scoring system for postoperative complications and mortality in elderly patients with colorectal cancer. Technol Health Care. 2024;32:465360.
  • 12. Kang S, Wilkinson K, Brungs D, Chua W, Ng W, Chen J, et al. Rectal cancer treatment and outcomes in elderly patients treated with curative intent. Mol Clin Oncol. 2021;15:256.
  • 13. Endo S, Yamatsuji T, Fujiwara Y, Higashida M, Kubota H, Matsumoto H, et al. Prognostic factors for elderly gastric cancer patients who underwent gastrectomy. World J Surg Oncol. 2022;20:10.
  • 14. Endo S, Higashida M, Furuya K, Yano S, Okada T, Yoshimatsu K, et al. Prognostic factors for gastric cancer patients aged ≥ 85 years. BMC Cancer. 2024;24:745.
  • 15. Qiang Li, Yingjun Lu. Predictive value of POSSUM scoring system for postoperative complications and mortality in elderly patients with colorectal cancer. Technol Health Care. 2024;8;32(6):4653–4660.
  • 16. Kim SY, Kim JH, Chin H, Jun KH. Prediction of postoperative mortality and morbidity in octogenarians with gastric cancer - comparison of P-POSSUM, O-POSSUM, and E-POSSUM. A retrospective single-center cohort study. Int J Surg. 2020;77:6468.
  • 17. Matsubara D, Soga K, Ikeda J, Konishi T, Uozumi Y, Takeda R, et al. Laparoscopic Surgery for Elderly Colorectal Cancer Patients With High American Society of Anesthesiologists Scores. Anticancer Res. 2023;43:5637–44.
  • 18. Rosa F, Tortorelli A. P, Quero G., Galliandro F., Fiorllio C., Sollazzi L, et al. The impact of preoperative ASA-physical statuson postoperative complications and long-term survival outcomes in gastric cancer patients. European Review for Medical and Pharmacological Sciences. 2019;23:7383–7390.
  • 19. Lu Q, Lu J-W, Wu Z, Liu X-M, Li J-H, Dong J, et al. Perioperative outcome of elderly versus younger patients undergoing major hepatic or pancreatic surgery. Clin Interv Aging. 2018;13:13341

Yıl 2025, Cilt: 15 Sayı: 2, 208 - 213, 31.08.2025

Öz

Kaynakça

  • 1. Schlesinger-Raab A, Werner J, Friess H, Hölzel D, Engel J. Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer. Visc Med. 2017;33:245–53.
  • 2. Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (20082030): a population-based study. Lancet Oncol. 2012;13:790801.
  • 3. Millan M, Merino S, Caro A, Feliu F, Escuder J, Francesch T. Treatment of colorectal cancer in the elderly. World J Gastrointest Oncol. 2015;7:204.
  • 4. Extermann M, Hurria A. Comprehensive Geriatric Assessment for Older Patients With Cancer. Journal of Clinical Oncology. 2007;25:1824–31.
  • 5. Thiels CA, Bergquist JR, Meyers AJ, Johnson CL, Behm KT, Hayman A V, et al. Outcomes with multimodal therapy for elderly patients with rectal cancer. Journal of British Surgery. 2016;103:e106–14.
  • 6. Fentiman I. Treatment of cancer in the elderly. Br J Cancer. 1991;64:993–5.
  • 7. Audisio RA, Veronesi P, Ferrario L, Cipolla C, Andreoni B, Aapro M. Elective surgery for gastrointestinal tumours in the elderly. Annals of Oncology. 1997;8:317–26.
  • 8. Alexander HR, Turnbull AD, Salamone J, Keefe D, Melendez J. Upper abdominal cancer surgery in the very elderly. J Surg Oncol. 1991;47:82–6.
  • 9. Welch CS. Surgery in the Aged. New England Journal of Medicine. 1948;238:821–32.
  • 10. Yeager MP, Glass DD, Neff RK, Brinck-Johnsen T. Epidural Anesthesia and Analgesia in High-risk Surgical Patients. Anesthesiology. 1987;66:729–36.
  • 11. Li Q, Lu Y. Predictive value of POSSUM scoring system for postoperative complications and mortality in elderly patients with colorectal cancer. Technol Health Care. 2024;32:465360.
  • 12. Kang S, Wilkinson K, Brungs D, Chua W, Ng W, Chen J, et al. Rectal cancer treatment and outcomes in elderly patients treated with curative intent. Mol Clin Oncol. 2021;15:256.
  • 13. Endo S, Yamatsuji T, Fujiwara Y, Higashida M, Kubota H, Matsumoto H, et al. Prognostic factors for elderly gastric cancer patients who underwent gastrectomy. World J Surg Oncol. 2022;20:10.
  • 14. Endo S, Higashida M, Furuya K, Yano S, Okada T, Yoshimatsu K, et al. Prognostic factors for gastric cancer patients aged ≥ 85 years. BMC Cancer. 2024;24:745.
  • 15. Qiang Li, Yingjun Lu. Predictive value of POSSUM scoring system for postoperative complications and mortality in elderly patients with colorectal cancer. Technol Health Care. 2024;8;32(6):4653–4660.
  • 16. Kim SY, Kim JH, Chin H, Jun KH. Prediction of postoperative mortality and morbidity in octogenarians with gastric cancer - comparison of P-POSSUM, O-POSSUM, and E-POSSUM. A retrospective single-center cohort study. Int J Surg. 2020;77:6468.
  • 17. Matsubara D, Soga K, Ikeda J, Konishi T, Uozumi Y, Takeda R, et al. Laparoscopic Surgery for Elderly Colorectal Cancer Patients With High American Society of Anesthesiologists Scores. Anticancer Res. 2023;43:5637–44.
  • 18. Rosa F, Tortorelli A. P, Quero G., Galliandro F., Fiorllio C., Sollazzi L, et al. The impact of preoperative ASA-physical statuson postoperative complications and long-term survival outcomes in gastric cancer patients. European Review for Medical and Pharmacological Sciences. 2019;23:7383–7390.
  • 19. Lu Q, Lu J-W, Wu Z, Liu X-M, Li J-H, Dong J, et al. Perioperative outcome of elderly versus younger patients undergoing major hepatic or pancreatic surgery. Clin Interv Aging. 2018;13:13341
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Doğan Gönüllü

Mert Güler Bu kişi benim

Feyza Kaya Bu kişi benim

Fırat Yetiş

Fatma Teksar Bu kişi benim

Muhammed Özdemir

Ahmet Muzaffer Er Bu kişi benim

Yayımlanma Tarihi 31 Ağustos 2025
Gönderilme Tarihi 19 Şubat 2025
Kabul Tarihi 24 Temmuz 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 15 Sayı: 2

Kaynak Göster

APA Gönüllü, D., Güler, M., Kaya, F., … Yetiş, F. (2025). Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity. Kafkas Journal of Medical Sciences, 15(2), 208-213.
AMA Gönüllü D, Güler M, Kaya F, vd. Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity. KAFKAS TIP BİL DERG. Ağustos 2025;15(2):208-213.
Chicago Gönüllü, Doğan, Mert Güler, Feyza Kaya, Fırat Yetiş, Fatma Teksar, Muhammed Özdemir, ve Ahmet Muzaffer Er. “Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity”. Kafkas Journal of Medical Sciences 15, sy. 2 (Ağustos 2025): 208-13.
EndNote Gönüllü D, Güler M, Kaya F, Yetiş F, Teksar F, Özdemir M, Er AM (01 Ağustos 2025) Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity. Kafkas Journal of Medical Sciences 15 2 208–213.
IEEE D. Gönüllü, M. Güler, F. Kaya, F. Yetiş, F. Teksar, M. Özdemir, ve A. M. Er, “Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity”, KAFKAS TIP BİL DERG, c. 15, sy. 2, ss. 208–213, 2025.
ISNAD Gönüllü, Doğan vd. “Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity”. Kafkas Journal of Medical Sciences 15/2 (Ağustos2025), 208-213.
JAMA Gönüllü D, Güler M, Kaya F, Yetiş F, Teksar F, Özdemir M, Er AM. Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity. KAFKAS TIP BİL DERG. 2025;15:208–213.
MLA Gönüllü, Doğan vd. “Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity”. Kafkas Journal of Medical Sciences, c. 15, sy. 2, 2025, ss. 208-13.
Vancouver Gönüllü D, Güler M, Kaya F, Yetiş F, Teksar F, Özdemir M, vd. Preoperative Risk Scores in Elderly with Gastrointestinal Malignancies: Their Predictive Value for Postoperative Mortality and Morbidity. KAFKAS TIP BİL DERG. 2025;15(2):208-13.