Investigating of the Antioxidant Activity of Firstly Synthesized Benzimidazole Derivatives
Öz
Antioxidant is a defence mechanism in thehuman body preventing the
occurence of oxygen types and the damage generated by them. They are used for
neutralizing free radicals. The presence of antioxidants activity indicates the
presence of the defense mechanism against the various diseases in the human
body. In
this study, activities of for the first time synthesized benzimidazole
compounds antioxidant activities are investigated spectrophotometrically. The
antioxidant activities of benzimidazole derivatives were investigated by
different antioxidant tests such as DPPH radical scavenging activity, ABTS
radical scavenging activity and reducing power. All results were compared with
synthetic antioxidants such as BHT and Trolox. As the
result of the study, antioxidant activity level of the compounds especially 2, 5, 6a, 6b and 7b which are benzimidazole derivatives are found higher extent too
there compounds.
Anahtar Kelimeler
Benzimidazole Derivatives,Antioxidant,DPPH Activity,ABTS Activity
Kaynakça
- 1. Alagöz, Z.G., Can-Eke, B., Coban, T., Iscan, M., Büyükbingöl, E. (2004). Antioxidant properties of novel benzimidazole petinoids. Archives of Pharmaceutical Pharma Medicinal Chemistry. 337: 188-192.
- 2. Arnao, M.B., (2000). Some methodological problems in the determination of antioxidant activity using chromogen radicals. A practical case. Trends in Food Science and Technology. 11: 419-421.
- 3. Baltaş, N., Menteşe, E., Pakyıldız, S., Yılmaz, F. (2015, Mart). Yeni benzimidazol türevi bileşiklerin sentezi, antioksidan özellikleri ve klinik öneme sahip bazı enzimler üzerine inhibisyon etkilerinin incelenmesi. 3.İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi, Rize- TURKEY.
- 4. Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 26: 1119-1200.
- 5. Brand-Williams, W., Cuvelier, M.E., Berset, C. (1995). Use of a free radical method to evaluate antioxidant acitivity, Lebensmittel-Wissenschaft und-Technologie/Food Science and Technolog, 28: 25-30.
- 6. Chakrabarty, M., Karmakar, S., Mukherji, A., Arima, S., Harigaya, Y. (2006). Application of sulfamic acid as an eco-friendly catalyst in an expedient synthesis of benzimidazoles. Heterocycles. 68: 967-974.
- 7. Eş, S. (2013).İlk defa sentezlenen 1,2,4-triazol schiff bazı bileşiklerininantioksidan, anti-elastaz ve anti-tirozinaz aktivitelerinin incelenmesi. Giresun Üniversitesi, Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, pp. 92, Giresun.
- 8. Foye, W.O. (1995). Cancer Chemotherapeutic Agents. American Chemical Society. 1-212.
- 9. Demirayak, S., Kayagil, I., Yurttas, L. (2011). Microwave supported synthesis of some novel 1,3-diarylpyrazino[1,2-a]benzimidazol derivatives and investigation of their anticancer activities. European Journal of Medicinal Chemistry, 46 (1): 411-416.
- 10. Going, C.J., Mayer, V.W. (1995). Induction of chromosome loss in saccharomyces cerevisiae strain D61.M by selected benzimidazole compounds. Mutation Research. 343: 185-199.