Investigating of the Antioxidant Activity of Firstly Synthesized Benzimidazole Derivatives

Yıl 2017, Cilt: 7 Sayı: 2, 87 - 95, 15.12.2017

Bahar Bilgin Sökmen , Tuğba Serter Demet Çakır Hakan Bektaş

https://doi.org/10.31466/kfbd.317706

Cited By: 2

Öz

Antioxidant is a defence mechanism in thehuman body preventing the
occurence of oxygen types and the damage generated by them. They are used for
neutralizing free radicals. The presence of antioxidants activity indicates the
presence of the defense mechanism against the various diseases in the human
body. In
this study, activities of for the first time synthesized benzimidazole
compounds antioxidant activities are investigated spectrophotometrically. The
antioxidant activities of benzimidazole derivatives were investigated by
different antioxidant tests such as DPPH radical scavenging activity, ABTS
radical scavenging activity and reducing power. All results were compared with
synthetic antioxidants such as BHT and Trolox. As the
result of the study, antioxidant activity level of the compounds especially 2, 5, 6a, 6b and 7b which are benzimidazole derivatives are found higher extent too
there compounds.

Anahtar Kelimeler

Benzimidazole Derivatives, Antioxidant, DPPH Activity, ABTS Activity

İlk Defa Sentezlenen Benzimidazol Türevlerinin Antioksidan Aktivitesinin İncelenmesi

Öz

Antioksidanlar, reaktif oksijen türlerinin oluşumunu ve bunların meydana
getirdiği hasarı önlemek için vücutta bulunan savunma mekanizmalarıdır. Serbest
radikalleri nötralize etmek için kullanılırlar. Antioksidan aktivitesinin
varlığı, vücutta meydana gelebilecek çeşitli hastalıklara karşı savunma mekanizmasının
var olduğunu göstermektedir. Bu çalışmada, ilk defa sentezlenen benzimidazol
türevlerinin antioksidan aktiviteleri spektrofotometrik olarak incelendi.
Benzimidazol türevlerinin antioksidan aktiviteleri, DPPH, ABTS radikal giderme
aktivitesi ve indirgeme gücü gibi çeşitli antioksidan testleri ile tayin
edildi. Elde edilen sonuçlar, BHT ve Troloks gibi sentetik antioksidanlarla
karşılaştırıldı. Yapılan
çalışmalar sonucunda benzimidazol bileşiklerinden
özellikle 2, 5, 6a, 6b ve 7b nolu bileşiklerin antioksidan
aktivite değerleri diğer bileşiklere oranla daha yüksek bulundu.

Anahtar Kelimeler

Benzimidazol Türevleri, Antioksidan Aktivite, DPPH Aktivitesi, ABTS Aktivitesi

Kaynakça

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