Sıçanlarda Deneysel Kafa Travması Sonrası Kan Şekeri Değişikliklerinin İstatistiksel Analizi

Yıl 2024, Cilt: 14 Sayı: 3, 1623 - 1629, 15.09.2024

Mehmet Meral

https://doi.org/10.31466/kfbd.1527755

Öz

Travmaya bağlı santral sinir sistemi hasarları önemli ölüm ve sakatlık sebebidir. Ancak travma sonucu oluşan hasardan sadece primer beyin harabiyeti değil bunu takip eden kompleks fizyopatolojik sekonder olaylar da sorumludur. Travma sonrası beyin dokusunun sistemik bozukluklara daha duyarlı hale geldiği tespit edilmiştir. Travma sonrası ortaya çıkan hipoksi ve iskemik olaylar sereberal enerji metabolizmasını belirgin şekilde etkileyerek yaygın beyin harabiyeti oluştururlar. Ağır kafa travmasını takiben erken dönmede hipergliseminin mevcut olduğu, kan glikoz düzeyi ile travmayı takiben iyileşme arasında negatif ilişki olduğu gösterilmiştir. Deneyde toplam 42 adet 250/350 gram ağırlığında erkek Wistar albino sıçan kullanıldı. Sıçanların 36 tanesinde yukarıda belirtildiği şekilde kafa travması oluşturuldu. Altı tanesinde travma oluşturulmadı, kontrol grubu olarak ölçümleri yapıldı. Çalışmamızda travma grubundaki sıçanlarda travma sonrası yapılan tüm ölçümlerde belirgin hiperglisemi tespit edildi (P<0.0001). Hiperglisemi ilk 24 saat içerisinde en yüksek seviyede seyretti. 48 saatten sonra azalmakla birlikte 7. günde kan şekeri değerleri travma öncesi değerlerin üzerinde görüldü (P<0.0001). Kontrol grubunda tüm ölçümlerde kan şekeri değerleri normal seyretti.

Anahtar Kelimeler

Ağır kafa travması, Kan şekeri, Deneysel ağır kafa travması

Statistical Analysis of Blood Glucose Changes After Experimental Head Trauma in Rats

Öz

Trauma-related central nervous system injuries are an important cause of death and disability. However, not only primary brain damage but also complex physiopathological secondary events are responsible for the damage caused by trauma. It has been determined that brain tissue becomes more sensitive to systemic disorders after trauma. Post-traumatic hypoxia and ischaemic events markedly affect cerebral energy metabolism and cause widespread brain damage. It has been shown that hyperglycemia is present in early recovery following severe head trauma and that there is a negative correlation between blood glucose level and recovery following trauma. A total of 42 male Wistar albino rats weighing 250/350 grams were used in the experiment. Head trauma was induced in 36 rats as described above. Six rats were not traumatized and measured as a control group. In our study, significant hyperglycemia was detected in all measurements made after trauma in rats in the trauma group (P<0.0001). Hyperglycaemia was at the highest level in the first 24 hours. Although it decreased after 48 hours, blood glucose values were above the pre-trauma values on the 7th day (P<0.0001). In the control group, blood glucose values were normal in all measurements.

Anahtar Kelimeler

Severe head trauma, Blood glucose, Experimental severe head trauma

Kaynakça

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