Katı-Hal PVC-Membran Benzidamin-Seçici Potansiyometrik Mikrosensör

Yıl 2025, Cilt: 15 Sayı: 1, 419 - 433, 15.03.2025

Nurşen Dere

https://doi.org/10.31466/kfbd.1581761

Öz

Bu çalışmada, benzidamin-tetrafenilborat (BNZ-TFB) iyon çifti kullanılarak tümüyle katı-hal tipi polivinilklorür (PVC) membran potansiyometrik mikrosensör geliştirilmiştir. Mikrosensörün membran yapısında iyonofor olarak benzidamin-tetrafenilborat iyon çifti kullanılmıştır. Benzidamin (BNZ) seçici mikrosensörün potansiyometrik performans özellikleri araştırılmıştır. Geliştirilen sensörün tayin limiti 6,2×10-6 mol.L-1, cevap süresi oldukça kısa (≤10 s), kullanım ömrü ~7 hafta, eğim değerinin 58,1±0,6 mV (R2: 0,9998), doğrusal çalışma aralığı 1×10-5−1×10-2 mol.L-1 olduğu belirlenmiştir. Mikrosensörün 4,0-7,0 pH aralığında optimum performansa sahip olduğu belirlenmiştir. Mikrosensör, farmasötik ilaç numunelerinde benzdiaminin potansiyometrik tayininde başarıyla kullanılmıştır. Elde edilen sonuçlar istatistiksel olarak UV-Vis spektroskopi yöntemiyle karşılaştırılmıştır. Elde edilen potansiyometrik sonuçların UV-Vis spektroskopi yöntemiyle elde edilen sonuçlarla %95 güven seviyesinde uyum içerisinde olduğu belirlenmiştir.

Anahtar Kelimeler

Benzidamin, Potansiyometri, Mikrosensör, İlaç, PVC-membran

Solid-State PVC-Membrane Benzydamine-Selective Potentiometric Microsensor

Öz

In this study, an all-solid-state type polyvinylchloride (PVC) membrane potentiometric microsensor was developed using benzydamine-tetraphenylborate (BNZ-TFB) ion-pair. Benzydamine-tetraphenylborate ion pair was used as an ionophore in the membrane structure of the microsensor. The potentiometric performance properties of benzydamine (BNZ) selective microsensor were investigated. The developed microsensor was determined to have a detection limit of 6.2×10-6 mol.L-1, a very short response time (≤10 s), a lifetime of ~7 weeks, a slope value of 58.1±0.6 mV (R2: 0.9998), and a linear operating range of 1×10-5−1×10-2 mol.L-1. It was determined that the microsensor had optimum performance in the pH range of 4.0-7.0. The microsensor successfully performed the potentiometric determination of benzdiamine in pharmaceutical drug samples. The results were compared statistically with the UV-Vis spectroscopy method. It was determined that the potentiometric results obtained were in agreement with the results obtained with the UV-Vis spectroscopy method at a confidence level of 95%.

Anahtar Kelimeler

Benzydamine, Potentiometry, Microsensor, Drug, PVC-membrane

Kaynakça

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