Beyond the Lipid-lowering Effects of Statins: Renal Effects

Yıl 2017, Cilt: 20 Sayı: 3, 240 - 247, 03.12.2017

Yasemin Kaya Ahmet Kaya Osman Bekataş

Öz

Nowadays
statins, 3 hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase enzyme
inhibitors, are used in the treatment of hyperlipidemia. Statins have been
shown to decrease cardiovascular mortality and morbidity in both coronary
artery disease and peripheral arterial disease. Besides their lipid-lowering
effects, statins have pleiotropic effects such as improvement of endothelial
dysfunction, atherosclerotic plaques stabilization, oxidative stress
inhibition, anti-inflammatory, and antithrombogenic effects. Some clinical
trials have revealed that statin therapy improved renal function. On the other
hand, statins have been shown to have no beneficial effects in many studies in
renal function. In this review, we aimed to evaluate the effects of statins on
renal function.

Anahtar Kelimeler

Statin, chronic renal disease, acute renal disease, contrast-induced nephropathy

Statinlerin Lipit Düşürücü Etkilerinin Ötesi: Renal Etkileri

Öz

Statin
3-hidroksi-3-metilglutaril CoA (HMG CoA) redüktaz enzim inhibitörü olarak
günümüzde hiperlipidemi tedavisinde yaygın olarak kullanılmaktadır. Özellikle
koroner arter hastalığı ve periferik arter hastalığında morbidite ve
mortaliteyi azalttığı gösterilmiştir. Aynı zamanda aterosklerotik plak
stabilizasyonu, endotel fonksiyonunu iyileştirme, oksidatif stres, inflamasyon
ve tromboza yanıtın inhibisyonu gibi pleiotropik etkileri de bulunmaktadır.
Statinin kanıtlanmış birçok yararlı etkisinin olmasının yanında, özellikle
böbrek fonksiyonları üzerine etkisiyle ilgili çalışmalarda çelişkili sonuçlar
bulunmaktadır. Bazı klinik çalışmalarda statinin böbrek fonksiyonları üzerine
faydalı olduğu saptanmışken, birçok çalışmada da faydalı etkisinin olmadığı gösterilmiştir.
Biz bu derlemede statin ile akut, kronik ve kontrasta bağlı nefropati
ilişkilerini araştıran çalışmaları inceleyerek, statinin böbrek fonksiyonları
üzerine etkisini değerlendirmeye çalıştık.

Anahtar Kelimeler

Statin, kronik böbrek yetersizliği, akut böbrek yetersizliği, kontrast nefropati

Kaynakça

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