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Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm

Yıl 2021, Cilt 5, Sayı 2, 147 - 161, 31.08.2021
https://doi.org/10.33720/kisgd.951525

Öz

Yaygın olarak kullanılan, bir ağır metal olan manganez (Mn), biyolojik fonksiyonları yürüten birçok enzimatik işlem için gerekli olan bir eser elementtir. Bununla birlikte, Mn’e aşırı maruz kalım, toksisiteye yol açmaktadır. Bu toksisitenin santral sinir sistemine etkileri özel önem taşımaktadır. Mn aşırı maruz kalımı tipik olarak parkinsonizm olarak ortaya çıkmakta ve daha yaygın görülen idiyopatik Parkinson hastalığından ayırt edilmesi zor olabilmektedir. Mesleki ve çevresel maruz kalıma ek olarak, sistemik hastalıklar, total parenteral beslenme ve bazı ilaçlar Mn toksisitesinin diğer potansiyel etiyolojileri arasında sayılabilir. Bu derlemede; Mn mesleki ve çevresel maruz kalımı, patofizyolojisi ve klinik özellikleri ele alınmıştır. Ayrıca, Mn'in iş yerindeki etkisi ve bir toksisitenin nörodejeneratif bir hastalık olarak tanılanmaması için ayrıntılı bir mesleki ve çevresel öykünün gerekliliği vurgulanmıştır. Kapsamlı bir tedavinin yokluğunda, erken tanı ve önleyici tedbirlerin zamanında başlatılması, Mn toksik etkilerinin yönetilmesinin anahtarıdır.

Kaynakça

  • ATSDR 2012. Toxicological Profile for Manganese, Agency for Toxic Substances and Disease Registry. US Public Health Service.
  • Kazeem B, Salako Mahbub MU. (2014). Manganese. Ladou J, Harrison RJ. (Ed.). Occupational&Envorimental Medicine (s.918-920). New York:Mc Graw Hill Education
  • T.C. Çalışma ve Sosyal Güvenlik Bakanlığı. (2012). Meslek Hastalıkları ve İş ile İlgili Hastalıklar Tanı Rehberi. Ankara: T.C. Çalışma ve Sosyal Güvenlik Bakanlığı.
  • WHO. Manganese and Its Compounds: Environmental Aspects. Geneva, 2004: 6-7.
  • Singaraju M, Singaraju S, Parwani R., 2012. Cytogenetic biomonitoring in petrol station attendants: A micronucleus study. Journal of Cytology/Indian Academy of Cytologists, 29:1–5.
  • Williams M, Todd GD, Roney N, Crawford J, Coles C, McClure PR, et al. Toxicological Profile for Manganese. Atlanta (GA): Agency for Toxic Substances and Disease Registry (US); 2012 Sep.
  • Azcona-Cruz MI, Rothenberg SJ, Schnaas L, Zamaro-Munoz JS, Romeroplaceres M. Lead-Glazed Ceramic Ware and Blood Lead Levels of Children in the City of Oaxaca, Mexico. Archives of Environmental Health. 2000:55(3):217-222.
  • Carrington CD, Bolger PM. Toxic Metals; Lead. Encylopadia of Food Safety. 2014 (2):349.
  • Agency for Toxic Substances and Disease Registry Toxicological Profile for Manganese. (2012). ATSDR. Erişim: 6 Mayıs 2021 http://www.atsdr. cdc.gov/toxprofiles/tp151.pdf.
  • Zeidler-Erdely PC, Erdely A, Antonini JM. Immunotoxicology of arc welding fume: Worker and experimental animal studies. Journal of Immunotoxicology. 2012;9(4):411-25.
  • Erdely A, Antonini JM, Young S-H, Kashon ML, Gu JK, Hulderman T, et al. Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats. Particle and Fibre Toxicology. 2014;11(1):34.
  • Shoeb M, Kodali V, Farris B, LM, Meighan T, Salmen R, et al. Evaluation of the molecular mechanisms associated with cytotoxicity and inflammation after pulmonary exposure to different metal-rich welding particles. Nanotoxicology. 2017;11(6):725-36.
  • Taube F. Manganese in occupational arc welding fumes: Aspects on physiochemical properties, with focus on solubility. Annals of Occupational Hygiene. 2012;57(1):6-25.
  • Antonini JM, Roberts JR, Chapman RS, Soukup JM, Ghio AJ, Sriram K. Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumes. Inhalation Toxicology. 2010;22(10):805-16.
  • Chia SE, Foo SC, Gan SL, Jeyaratnam J, Tian CS. Neurobehavioral functions among workers exposed to manganese ore. Scand J Work Environ Health 1993;19:264-270.
  • Lucchini R, Selis L, Folli D, Apostoli P, Mutti A, Vanoni O, et al. Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure. Scand J Work Environ Health 1995;21:143- 149.
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  • Zayed J. Use of MMT in Canadian gasoline: health and environment issues. American Journal of Industrial Medicine 2001; 39(4), 426-433.
  • Pouchieu C, Piel C, Carles C, Gruber A, Helmer C, Tual S, et al. Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study. Int J Epidemiol 2018;47:299-310.
  • Mergler D, Baldwin M, Bélanger S, Larribe F, Beuter A, Bowler R, et al. Manganese neurotoxicity, a continuum of dysfunction: Results from a community based study. Neurotoxicology 1999;20:327-342.
  • Lucchini RG, Albini E, Benedetti L, Borghesi S, Coccaglio R, Malara EC, et al. High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries. American Journal of Industrial Medicine 2007;50: 788-800.
  • Standridge JS, Bhattacharya A, Succop P, Cox C, Haynes E. Effect of chronic low level manganese exposure on postural balance: A pilot study of residents in Southern Ohio. J Occup Environ Med 2008;50:1421-1429.
  • Winder BS. Manganese in the air: Are children at greater risk than adults? J Toxicol Environ Health A 2010;73:156-158.
  • Kullar SS, Shao K, Surette C, Foucher D, Mergler D, Cormier P, et al. A benchmark concentration analysis for manganese in drinking water and IQ deficits in children. Environ Int 2019;130:104889.
  • Neal AP, Guilarte TR. Mechanisms of lead and manganese neurotoxicity. 700. Toxicol Res (Camb) 2013;2:99-114.
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  • Goldhaber SB. Trace element risk assessment: essentiality vs. toxicity.Regul Toxicol Pharmacol 2003; 38(2):232-42.
  • Cikrt M. VEGJ. Manganese. Environmental Health Criteria: Genevra; 1981. Report No.: 17.
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Health Effects of Manganese Exposure at Workplace and Parkinsonism

Yıl 2021, Cilt 5, Sayı 2, 147 - 161, 31.08.2021
https://doi.org/10.33720/kisgd.951525

Öz

Manganese (Mn), a heavy metal commonly used in industry, is a trace element required for many enzymatic processes that drive biological functions. However, excess exposure to Mn leads to toxicity. Its toxic effects on the central nervous system are important. The typical manifestation of Mn over exposure is parkinsonism, which may be challenging to differentiate it from more common idiopathic Parkinson's disease. In addition to occupational and environmental exposure to Mn, other potential etiologies causing Mn toxicity include systemic diseases, total parenteral nutrition and some drugs. In this review, we evaluated occupational and environmental exposure of Mn, its pathophysiology and clinical characteristics. We have highlighted the impact of Mn exposure at the workplace and emphasize the necessity of a detailed occupational and environmental history to ensure that a toxicity is not misdiagnosed as a neurodegenerative disease. In the absence of a comprehensive treatment, early diagnosis and timely initiation of preventive measures are the keys to managing Mn toxic effects.

Kaynakça

  • ATSDR 2012. Toxicological Profile for Manganese, Agency for Toxic Substances and Disease Registry. US Public Health Service.
  • Kazeem B, Salako Mahbub MU. (2014). Manganese. Ladou J, Harrison RJ. (Ed.). Occupational&Envorimental Medicine (s.918-920). New York:Mc Graw Hill Education
  • T.C. Çalışma ve Sosyal Güvenlik Bakanlığı. (2012). Meslek Hastalıkları ve İş ile İlgili Hastalıklar Tanı Rehberi. Ankara: T.C. Çalışma ve Sosyal Güvenlik Bakanlığı.
  • WHO. Manganese and Its Compounds: Environmental Aspects. Geneva, 2004: 6-7.
  • Singaraju M, Singaraju S, Parwani R., 2012. Cytogenetic biomonitoring in petrol station attendants: A micronucleus study. Journal of Cytology/Indian Academy of Cytologists, 29:1–5.
  • Williams M, Todd GD, Roney N, Crawford J, Coles C, McClure PR, et al. Toxicological Profile for Manganese. Atlanta (GA): Agency for Toxic Substances and Disease Registry (US); 2012 Sep.
  • Azcona-Cruz MI, Rothenberg SJ, Schnaas L, Zamaro-Munoz JS, Romeroplaceres M. Lead-Glazed Ceramic Ware and Blood Lead Levels of Children in the City of Oaxaca, Mexico. Archives of Environmental Health. 2000:55(3):217-222.
  • Carrington CD, Bolger PM. Toxic Metals; Lead. Encylopadia of Food Safety. 2014 (2):349.
  • Agency for Toxic Substances and Disease Registry Toxicological Profile for Manganese. (2012). ATSDR. Erişim: 6 Mayıs 2021 http://www.atsdr. cdc.gov/toxprofiles/tp151.pdf.
  • Zeidler-Erdely PC, Erdely A, Antonini JM. Immunotoxicology of arc welding fume: Worker and experimental animal studies. Journal of Immunotoxicology. 2012;9(4):411-25.
  • Erdely A, Antonini JM, Young S-H, Kashon ML, Gu JK, Hulderman T, et al. Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats. Particle and Fibre Toxicology. 2014;11(1):34.
  • Shoeb M, Kodali V, Farris B, LM, Meighan T, Salmen R, et al. Evaluation of the molecular mechanisms associated with cytotoxicity and inflammation after pulmonary exposure to different metal-rich welding particles. Nanotoxicology. 2017;11(6):725-36.
  • Taube F. Manganese in occupational arc welding fumes: Aspects on physiochemical properties, with focus on solubility. Annals of Occupational Hygiene. 2012;57(1):6-25.
  • Antonini JM, Roberts JR, Chapman RS, Soukup JM, Ghio AJ, Sriram K. Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumes. Inhalation Toxicology. 2010;22(10):805-16.
  • Chia SE, Foo SC, Gan SL, Jeyaratnam J, Tian CS. Neurobehavioral functions among workers exposed to manganese ore. Scand J Work Environ Health 1993;19:264-270.
  • Lucchini R, Selis L, Folli D, Apostoli P, Mutti A, Vanoni O, et al. Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure. Scand J Work Environ Health 1995;21:143- 149.
  • Myers JE, Thompson ML, Ramushu S, Young T, Jeebhay MF, London L, et al. The nervous system effects of occupational exposure on workers in a South African manganese smelter. Neurotoxicology 2003;24:885-894.
  • Lee EY, Flynn MR, Lewis MM, Mailman RB, Huang X. Welding-related brain and functional changes in welders with chronic and low-level exposure. Neurotoxicology 2018;64:50-59.
  • O’Neal SL, Zheng W. Manganese toxicity upon over exposure: A decade in review. Curr Environ Health Rep 2015;2:315-328.
  • Zayed J. Use of MMT in Canadian gasoline: health and environment issues. American Journal of Industrial Medicine 2001; 39(4), 426-433.
  • Pouchieu C, Piel C, Carles C, Gruber A, Helmer C, Tual S, et al. Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study. Int J Epidemiol 2018;47:299-310.
  • Mergler D, Baldwin M, Bélanger S, Larribe F, Beuter A, Bowler R, et al. Manganese neurotoxicity, a continuum of dysfunction: Results from a community based study. Neurotoxicology 1999;20:327-342.
  • Lucchini RG, Albini E, Benedetti L, Borghesi S, Coccaglio R, Malara EC, et al. High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries. American Journal of Industrial Medicine 2007;50: 788-800.
  • Standridge JS, Bhattacharya A, Succop P, Cox C, Haynes E. Effect of chronic low level manganese exposure on postural balance: A pilot study of residents in Southern Ohio. J Occup Environ Med 2008;50:1421-1429.
  • Winder BS. Manganese in the air: Are children at greater risk than adults? J Toxicol Environ Health A 2010;73:156-158.
  • Kullar SS, Shao K, Surette C, Foucher D, Mergler D, Cormier P, et al. A benchmark concentration analysis for manganese in drinking water and IQ deficits in children. Environ Int 2019;130:104889.
  • Neal AP, Guilarte TR. Mechanisms of lead and manganese neurotoxicity. 700. Toxicol Res (Camb) 2013;2:99-114.
  • Abdalian R, Saqui O, Fernandes G, Allard JP. Effects of manganese froma commercial multi-trace element supplement in a population sample of Canadian patients on long-term parenteral nutrition. JPEN J Parenteral Nutr 2013;37:538-543.
  • Koksal A, Baybas S, Sozmen V, Koksal NS, Altunkaynak Y, Dirican A, et al. Chronic manganese toxicity due to substance abuse in Turkish patients. Neurol India 2012;60:224-227.
  • Smith D., Woodall GM., Jarabek AM, & Boyes WK. Manganese testing under a clean air act test rule and the application of resultant data in risk assessments. Neurotoxicology 2018; 64, 177-184.
  • Hasan H. Understanding the Element of the Periodic Table: Manganese. New York, Rosen Central, 2008:4-12.
  • Çelik A, Abalı Y, Edgünlü G, Uzunoğlu S, & Tirtom VN. İnsan saçında bulunan (Manisa ilinin üç farklı yerleşim bölgesinde) bazı ağır metallerin ICP-OES yöntemi ile tayini. Ekoloji 2009; 19(73), 71-75.
  • Goldhaber SB. Trace element risk assessment: essentiality vs. toxicity.Regul Toxicol Pharmacol 2003; 38(2):232-42.
  • Cikrt M. VEGJ. Manganese. Environmental Health Criteria: Genevra; 1981. Report No.: 17.
  • Lucchini R, Placidi D, Cagna G, Fedrighi C, Oppini M, Peli M, et al. Manganese and Developmental Neurotoxicity. Neurotoxicity of Metals: U.S.A., Springer; 2017.13-34.
  • Nordberg G., Fowler BA, Nordberg M, Friberg LT. Handbook on The Toxicology of Metals, U.S.A.: Academic Press; 2014.
  • OSHA Occupational Safety&Health Administration Manganese Fume, Manganese Compounds.[Internet]. [Erişim tarihi: 01.05.2021] Erişim adresi: https://www.osha.gov/dts/chemical
  • Raval G, Straughen JE, McMillin GA, Bornhorst JA.Unex- plained hemolytic anemia with multiorgan failure. Clin Chem 2011; 57(1485).
  • Roels H, Djubgang J, Buchet JP, Bernard A, & Lauwerys R. Evolution of cadmium-induced renal dysfunction in workers removed from exposures. Scandinavian Journal of Work, Environment & Health 1982; 191-200.
  • Agency for Toxic Substances and Disease Registry, Division of Toxicology, 2012. Toxicolgical Profile for manganese. Update Draft for Public Comments. ATSDR, Atlanta GA.
  • Pfeifer GD, Roper, J.M., Dorman, D., Lynam, D.R., 2004. Health and environmental testing of manganese exhaust products from use of methylcyclopentadienyl manganese tricarbonyl in gasoline. Sci Total Environ., 334- 335:397-408.
  • Goyer RA. and Clarkson TW. Toxic Effects of Metals. Casarett and Doullis Toxicology. New York: McGraw-Hill; 2001.
  • Nogawa K, Kobayashi E, Okubo Y, Suwazono Y. Environmental cadmium exposure, adverse effects and preventive measures in Japan. Biometals 2004;17(581).
  • Kulshreshtha D., Ganguly J, & Jog M. Manganese and Movement Disorders: A Review. Journal of Movement Disorders 2021;14(2), 93.
  • Aschner M, Erikson KM, Hernández EH, & Tjalkens R. Manganese and its role in Parkinson’s disease: From transport to neuropathology. Neuromolecular Medicine 2009;11(4), 252-266.
  • Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, BowmanAB, et al. Manganese homeostasis in the nervous system. J Neurochem 2015;134:601-610.
  • Huang C. Parkinsonism induced by chronic manganese intoxication-an experience in Taiwan. Chang Gung Medical Journal 2007;30(5), 385.
  • Harischandra DS, Ghaisas S, Zenitsky G, Jin H, Kanthasamy A, Anantharam V, & Kanthasamy AG. Manganese-induced neurotoxicity: New insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation. Frontiers in Neuroscience, 2019;13, 654.
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Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm İş Sağlığı ve Güvenliği
Yazarlar

Zehra GÖK METİN (Sorumlu Yazar)
Hacettepe Universitesi Hemsirelik Fakultesi
0000-0003-0311-9982
Türkiye


Abdulsamet SANDAL Bu kişi benim
Ankara Mesleki ve Çevresel Hastalıklar Hastanesi
0000-0002-9718-7769
Türkiye


Ali Naci YILDIZ
Hacettepe Üniversitesi Tıp Fakültesi Halk Sağlığı Anabilim Dalı
0000-0001-8148-4710
Türkiye

Yayımlanma Tarihi 31 Ağustos 2021
Başvuru Tarihi 14 Haziran 2021
Kabul Tarihi 11 Ağustos 2021
Yayınlandığı Sayı Yıl 2021, Cilt 5, Sayı 2

Kaynak Göster

Bibtex @derleme { kisgd951525, journal = {Karaelmas Journal of Occupational Health and Safety}, issn = {}, eissn = {2636-7602}, address = {kisgd@beun.edu.tr}, publisher = {Bülent Ecevit Üniversitesi}, year = {2021}, volume = {5}, pages = {147 - 161}, doi = {10.33720/kisgd.951525}, title = {Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm}, key = {cite}, author = {Gök Metin, Zehra and Sandal, Abdulsamet and Yıldız, Ali Naci} }
APA Gök Metin, Z. , Sandal, A. & Yıldız, A. N. (2021). Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm . Karaelmas Journal of Occupational Health and Safety , 5 (2) , 147-161 . DOI: 10.33720/kisgd.951525
MLA Gök Metin, Z. , Sandal, A. , Yıldız, A. N. "Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm" . Karaelmas Journal of Occupational Health and Safety 5 (2021 ): 147-161 <https://dergipark.org.tr/tr/pub/kisgd/issue/64713/951525>
Chicago Gök Metin, Z. , Sandal, A. , Yıldız, A. N. "Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm". Karaelmas Journal of Occupational Health and Safety 5 (2021 ): 147-161
RIS TY - JOUR T1 - Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm AU - Zehra Gök Metin , Abdulsamet Sandal , Ali Naci Yıldız Y1 - 2021 PY - 2021 N1 - doi: 10.33720/kisgd.951525 DO - 10.33720/kisgd.951525 T2 - Karaelmas Journal of Occupational Health and Safety JF - Journal JO - JOR SP - 147 EP - 161 VL - 5 IS - 2 SN - -2636-7602 M3 - doi: 10.33720/kisgd.951525 UR - https://doi.org/10.33720/kisgd.951525 Y2 - 2021 ER -
EndNote %0 Karaelmas İş Sağlığı ve Güvenliği Dergisi Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm %A Zehra Gök Metin , Abdulsamet Sandal , Ali Naci Yıldız %T Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm %D 2021 %J Karaelmas Journal of Occupational Health and Safety %P -2636-7602 %V 5 %N 2 %R doi: 10.33720/kisgd.951525 %U 10.33720/kisgd.951525
ISNAD Gök Metin, Zehra , Sandal, Abdulsamet , Yıldız, Ali Naci . "Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm". Karaelmas Journal of Occupational Health and Safety 5 / 2 (Ağustos 2021): 147-161 . https://doi.org/10.33720/kisgd.951525
AMA Gök Metin Z. , Sandal A. , Yıldız A. N. Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm. kisgd. 2021; 5(2): 147-161.
Vancouver Gök Metin Z. , Sandal A. , Yıldız A. N. Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm. Karaelmas Journal of Occupational Health and Safety. 2021; 5(2): 147-161.
IEEE Z. Gök Metin , A. Sandal ve A. N. Yıldız , "Çalışma Yaşamında Manganez Maruz Kalımının Sağlık Etkileri ve Parkinsonizm", Karaelmas Journal of Occupational Health and Safety, c. 5, sayı. 2, ss. 147-161, Ağu. 2021, doi:10.33720/kisgd.951525