USE OF MOLECULAR HYDROGEN IN HEALTH FIELD

Öz

Molecular hydrogen, which has the H2 formula, is a colorless, odorless, tasteless, non-metallic and non-toxic gas. Molecular hydrogen has a high diffusion rate and spreads rapidly in biological tissues and cells. Molecular hydrogen does not change the body's redox reactions and does not cause any side effects. H2 is a selective antioxidant due to its ability to neutralize strong oxidants such as hydroxyl radicals in cells. This case increases the potential use of molecular hydrogen for preventative and therapeutic applications. In addition, by regulating various gene expressions, H2 exhibits anti-inflammatory and anti- apoptotic properties. At the same time, unlike the drugs used in the treatment of diseases, H2 penetrates the cell membrane easily. Inhaling hydrogen gas, drinking hydrogen water, injection of hydrogen- enriched saline, bathing with a hydrogen-rich water, and hydrogen-rich eye drops are the common methods of molecular hydrogen applications in the health field. Numerous studies on the biological and medical benefits of hydrogen have been carried out up to date, and research is still ongoing. As a result; due to its beneficial effects on the body and the absence of side effects, molecular hydrogen can have promising potential applications against many diseases.

Anahtar Kelimeler

• Molecular hydrogen
• Hydrogen therapy
• Health field
• Selective antioxidant

MOLEKÜLER HİDROJENİN SAĞLIK ALANINDA KULLANIMI

Öz

H2 formülüne sahip olan moleküler hidrojen, renksiz, kokusuz, tatsız, metalik olmayan ve toksik olmayan bir gazdır. Moleküler hidrojen (H2), yüksek difüzyon hızına sahiptir ve biyolojik doku ve hücrelerde hızla yayılır. Moleküler hidrojen, vücudun redoks reaksiyonlarını değiştirmemekte ve hiçbir yan etki göstermemektedir. Hücrelerdeki hidroksil radikal gibi güçlü oksidanları inhibe etme özelliğinden dolayı seçici bir antioksidandır. Bu durum, moleküler hidrojenin önleyici ve tedavi edici uygulamalar için potansiyelini arttırmaktadır. Ek olarak, çeşitli gen ifadelerini düzenleyerek, antiinflamatuar ve antiapoptik özellik sergilemektedir. Aynı zamanda hastalıkların tedavisinde kullanılan ilaçların aksine moleküler hidrojen, hücre zarına kolaylıkla nüfuz etmektedir. Hidrojen gazı solumak, hidrojenle zenginleştirilmiş su içmek, hidrojenle zenginleştirilmiş salin enjeksiyonu, hidrojenli su banyosu yapmak ve hidrojenli göz damlaları kullanmak sağlık alanında moleküler hidrojen uygulamasının yaygın yöntemleridir. Bugüne kadar hidrojenin biyolojik ve tıbbi faydaları üzerine çok sayıda çalışma yapılmıştır ve araştırmalar halen devam etmektedir. Sonuç olarak; vücuttaki olumlu etkileri, yan etkisinin bulunmaması sebebiyle, moleküler hidrojen birçok hastalığa karşı umut verici bir potansiyele sahiptir.

Anahtar Kelimeler

• Moleküler hidrojen
• Hidrojen terapisi
• Sağlık alanı
• Seçici antioksidan

Kaynakça

1. Sun X, Ohta S, Nakao A. Hydrogen molecular biology and medicine: Springer; 2015.
2. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat med. 2007;13(6):688-694.
3. Hu Q, Zhou Y, Wu S, Wu W, Deng Y, Shao A. Molecular hydrogen: A potential radioprotective agent. Biomed Pharmacother. 2020;130:110589.
4. Ohta S. Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications. Methods Enzymol. 2015;555:289-317.
5. Dröge W. Free radicals in the physiological control of cell function. Physiological reviews. 2002.
6. Köktürk M, Yıldırım S, Eser G, Bulut M, Alwazeer D. Hydrogen-Rich Water Alleviates the Nickel-Induced Toxic Responses (Inflammatory Responses, Oxidative Stress, DNA Damage) and Ameliorates Cocoon Production in Earthworm. Biol Trace Elem Res. 2021;1-11.
7. Xie K-L, Hou L-C, Wang G-L, Xiong L-Z. Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice. Zhejiang da Xue Xue Bao. Yi Xue Ban. 2010;39(5):454-457.
8. Iketani M. and Ohsawa I. Molecular hydrogen as a neuroprotective agent. Curr Neuropharmacol. 2017;15(2):324-331.

9. Cejka C, Kossl J, Holan V, Zhang JH, Cejkova J. An immunohistochemical study of the increase in antioxidant capacity of corneal epithelial cells by molecular hydrogen, leading to the suppression of alkali-induced oxidative stress. Oxid med cell longev. 2020;2020:7435260.
10. Huang CS, Kawamura T, Toyoda Y, Nakao A. Recent advances in hydrogen research as a therapeutic medical gas. Free radic res. 2010;44(9):971-982.
11. Ohta S. Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr pharm des. 2011;17(22):2241-2252.
12. Noda K, Shigemura N, Tanaka Y, et al. A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Hear Lung Transplant. 2013;32(2):241-250.
13. Oharazawa H, Igarashi T, Yokota T, et al. Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia–reperfusion injury. Invest Ophthalmol Vis Sci. 2010;51(1):487-492.
14. Ono H, Nishijima Y, Adachi N, et al. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Med Gas Res. 2011;1(1):1-9.
15. Cai J, Kang Z, Liu WW, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model. Neurosci Lett. 2008;441(2):167-172.
16. Shen L, Wang J, Liu K, et al. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochem Res. 2011;36(8):1501-1511.
17. Tan X, Shen F, Dong WL, Yang Y, Chen G. The role of hydrogen in Alzheimer’s disease. Med Gas Res. 2018;8(4):176-180.
18. Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res. 2010;1328:152-161.
19. Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28(3):137-143.
20. Kamimura N, Nishimaki K, Ohsawa I, Ohta S. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity. 2011;19(7):1396-1403.
21. Fukuda K-i, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 2007;361(3):670-674.
22. Kawai D, Takaki A, Nakatsuka A, et al. Hydrogen‐rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology. 2012;56(3):912-921.
23. Mei K, Zhao S, Qian L, Li B, Ni J, Cai J. Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat. 2014;25(2):182-188.
24. Ignacio RM, Yoon Y-S, Sajo MEJ, et al. The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Mol Cell Toxicol. 2013;9(1):15-21.
25. Zhu Q, Wu Y, Li Y, et al. Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep. 2018;8(1):1-8.
26. Tanaka Y, Saitoh Y, Miwa N. Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Med Gas Res. 2018;8(1):12-18.
27. Ishibashi T, Ichikawa M, Sato B, et al. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep. 2015;12(2):2757-2764.
28. Guo SX, Jin YY, Fang Q, et al. Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PloS One. 2015;10(4):e0124897.
29. Mizuno K, Sasaki AT, Ebisu K, et al. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res. 2017;7(4):247-255.
30. Ostojic SM, Vukomanovic B, Calleja-Gonzalez J, Hoffman JR. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med. 2014;126(5):187-195.