THE VARIOUS THERAPEUTIC EFFECTS OF GINGER (ZINGIBER OFFICINALE ROSCOE) ON HUMAN HEALTH

Yıl 2021, Cilt: 2 Sayı: 2, 55 - 60, 31.08.2021

Damla Zeynep Bayraktar

https://doi.org/10.52831/kjhs.886448

Öz

Ginger is a yellowish root also called as spice which belongs to the zingiberaceae family and grown in various parts of the world, countries such as India, China, Nigeria, Sierra Leone, Indonesia, Bangladesh, Australia, Fiji, Jamaica and Nepal. It is a flowering plant with root, stem and leaves which can be consumed as fresh root, dried root, ground powder, pickle, ginger oil, ginger candy, ginger water or ginger tea. For thousands of years ginger has been used as a herbal medicine to prevent colds, digestive complaints, nausea and increase circulation in Ayurvedic, Indian and Chinese medicine. In addition to this, ginger is used as a medical plant in Roman, Greek and Ottoman medical history is shown in the records. Nowadays, there are many studies showing that it is important to prevent the nausea and vomiting due to chemotherapy, postoperative and in pregnancy; to use it in the treatment of colds, joint disease and asthma treatment; to reduce the risk of colorectal and prostate cancer, dysmenorrhea, diabetes and fat metabolism; and body composition in athletes improve exercise performance. When the effective components and chemical structure it contains are examined, two important phytochemicals, such as the volatile and non-volatile fatty acids show these effects of ginger. Although studies show positive effects of ginger on many health problems, more clinical research is needed to prove the most effective dose.

Anahtar Kelimeler

Ginger, Nausea, Dysmenorrhea, Dysmenorrhea, Cold, Bioactive compounds

ZENCEFİL’İN (ZINGIBER OFFICINALE ROSCOE) İNSAN SAĞLIĞI ÜZERİNE ÇEŞİTLİ TERAPÖTİK ETKİLERİ

Öz

Zencefil (zingiber officinale roscoe), çoğunlukla Hindistan, Çin, Nijerya, Sierra Leone, Endonezya, Bangladeş, Avustralya, Fiji, Jamaika ve Nepal gibi ülkelerden gelen ve dünyanın çeşitli yerlerinde yetiştirilen zencefilgiller (zingiberaceace) ailesinden olan, baharat olarak da anılan yumru köklü sarımtırak bir bitkidir. Kök, gövde ve yaprakları olan bu bitki; taze kök, kuru kök, öğütülmüş toz, turşu, zencefil yağı, zencefil şekerlemesi, zencefilli su veya zencefil çayı olarak tüketilebilmektedir. Ayurvedik, Hint ve Çin tıbbında, soğuk algınlığını, sindirim şikâyetlerini, mide bulantısını önlemek ve dolaşımı arttırmak için bitkisel ilaç olarak binlerce yıldır kullanılmış ve Roma, Yunan ve Osmanlı tıp tarihi kayıtlarında tıbbi bir bitki olarak kullanıldığı gösterilmiştir. Günümüzde kemoterapi kaynaklı, ameliyat sonrası ve hamilelikteki bulantı ve kusmayı önlemede; soğuk algınlığı tedavisinde, eklem hastalığı ve astım tedavisinde, kolorektal ve prostat kanseri riskini azaltmada, dismenore, diyabet ve yağ metabolizması üzerine etkisinin olduğu, vücut kompozisyonunu ve egzersiz performansını arttırdığını gösteren birçok çalışma vardır. İçerdiği biyoaktif bileşenleri ve kimyasal yapısı incelendiğinde yapısında bulunan uçucu ve uçucu olmayan yağ asitleri gibi iki önemli fitokimyasal etkenler zencefilin etkilerini ortaya koymaktadır. Çalışmalarda, zencefilin birçok sağlık sorunu üzerine olumlu etkilerinin görülmesine rağmen; en etkili dozunun kanıtlanması için daha fazla klinik araştırmaya ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Zencefil, Bulantı, Dismenore, Soğuk algınlığı, Biyoaktif bileşenler

Kaynakça

• 1. Konuklugil B, Özçelikay G. Zencefil’in (zingiber officinale) tarih boyunca önemi ve günümüzdeki kullanımı. Ankara Üniversitesi Osmanlı Tarihi Araştırma ve Uygul Merk Derg. 2004;16:173-189.
• 1. Konuklugil B, Özçelikay G. Zencefil’in (zingiber officinale) tarih boyunca önemi ve günümüzdeki kullanımı. Ankara Üniversitesi Osmanlı Tarihi Araştırma ve Uygul Merk Derg. 2004;16:173-189.
• 2. Başer KHC. Zencefil (zingiber officinale roscoe). Bağbahçe. 2013;48:30-31.
• 2. Başer KHC. Zencefil (zingiber officinale roscoe). Bağbahçe. 2013;48:30-31.
• 3. Kılıç N. Zencefil. Pharmaşark. 2001;4:18-21.
• 3. Kılıç N. Zencefil. Pharmaşark. 2001;4:18-21.
• 4. Vasala PA. Ginger. In: handbook of herbs and spices. 2012;195-206.
• 4. Vasala PA. Ginger. In: handbook of herbs and spices. 2012;195-206.
• 5. Aydın H. Bazı baharatların farklı ekstraktlarının antioksidan özelliklerinin belirlenmesi. Trakya Üniversitesi. 2011.
• 5. Aydın H. Bazı baharatların farklı ekstraktlarının antioksidan özelliklerinin belirlenmesi. Trakya Üniversitesi. 2011.
• 6. Kaplan H. Zencefilin (zingiber officinale roscoe) bitkisel özellikleri ve yetiştiriciliği. Derim. 2014;22(2):1-9.
• 6. Kaplan H. Zencefilin (zingiber officinale roscoe) bitkisel özellikleri ve yetiştiriciliği. Derim. 2014;22(2):1-9.
• 7. Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Taheri MM. The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes. Iran J Pharm Res. 2015;14(1):131-140.
• 7. Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Taheri MM. The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes. Iran J Pharm Res. 2015;14(1):131-140.
• 8. Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evid Based Complement Alternat Med. 2012;2012:516870.
• 8. Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evid Based Complement Alternat Med. 2012;2012:516870.
• 9. Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20(7):1479-1489.
• 9. Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20(7):1479-1489.
• 10. Marx W, McKavanagh D, McCarthy AL, et al. The effect of ginger (zingiber officinale) on platelet aggregation: A systematic literature review. PLoS One. 2015;10(10):1-13.
• 10. Marx W, McKavanagh D, McCarthy AL, et al. The effect of ginger (zingiber officinale) on platelet aggregation: A systematic literature review. PLoS One. 2015;10(10):1-13.
• 11. Marx W, McCarthy AL, Ried K, et al. Can ginger ameliorate chemotherapy-induced nausea? Protocol of a randomized double blind, placebo-controlled trial. BMC Complement Altern Med. 2014;14(134):1-11.
• 11. Marx W, McCarthy AL, Ried K, et al. Can ginger ameliorate chemotherapy-induced nausea? Protocol of a randomized double blind, placebo-controlled trial. BMC Complement Altern Med. 2014;14(134):1-11.
• 12. Hudson T. Ginger (zingiber officinale roscoe) an overview of its safety and efficacy. Plant Intell Prof Resour. 2010;2.
• 12. Hudson T. Ginger (zingiber officinale roscoe) an overview of its safety and efficacy. Plant Intell Prof Resour. 2010;2.
• 13. Gürün MS, Süzer Ö. Bitkisel ilaçlar. In: Süzer Farmakoloji. 2004;533-540.
• 13. Gürün MS, Süzer Ö. Bitkisel ilaçlar. In: Süzer Farmakoloji. 2004;533-540.
• 14. Gupta SK, Sharma A. Medicinal properties of zingiber officinale roscoe-a review. IOSR J Pharm Biol Sci. 2014;9(5):124-129.
• 14. Gupta SK, Sharma A. Medicinal properties of zingiber officinale roscoe-a review. IOSR J Pharm Biol Sci. 2014;9(5):124-129.
• 15. Ghosh AK. Zingiber officinale: a natural gold. Int J Pharma Bio Sci. 2011;2(1):283-194.
• 15. Ghosh AK. Zingiber officinale: a natural gold. Int J Pharma Bio Sci. 2011;2(1):283-194.
• 16. Singletary K. Ginger an overview of health benefits. Nutr Today. 2010;45(4):171-183.
• 16. Singletary K. Ginger an overview of health benefits. Nutr Today. 2010;45(4):171-183.
• 17. Zadeh JB, Kor NM. Physiological and pharmaceutical effects of ginger (zingiber officinale roscoe) as a valuable medicinal plant. Eur J Exp Biol. 2014;4(1):87-90.
• 17. Zadeh JB, Kor NM. Physiological and pharmaceutical effects of ginger (zingiber officinale roscoe) as a valuable medicinal plant. Eur J Exp Biol. 2014;4(1):87-90.
• 18. Shirin Adel PR, Prakash J. Chemical composition and antioxidant properties of ginger root (zingiber officinale). J Med Plants Res. 2010;4(24):2674-2679.
• 18. Shirin Adel PR, Prakash J. Chemical composition and antioxidant properties of ginger root (zingiber officinale). J Med Plants Res. 2010;4(24):2674-2679.
• 19. Türk Diyetisyenler Derneği Yayını. Besinlerin bileşimi. Ankara: 1. Yeniçağ; 1991.
• 19. Türk Diyetisyenler Derneği Yayını. Besinlerin bileşimi. Ankara: 1. Yeniçağ; 1991.
• 20. Beslenme Bilgi Sistemi- BeBiS, Versiyon 7.2. İstanbul; 2017.
• 20. Beslenme Bilgi Sistemi- BeBiS, Versiyon 7.2. İstanbul; 2017.
• 21. Wang W, Li CY, Wen XD, Li P, Qi LW. Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. J Chromatogr B Anal Technol Biomed Life Sci. 2009;877(8-9):671-679.
• 21. Wang W, Li CY, Wen XD, Li P, Qi LW. Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. J Chromatogr B Anal Technol Biomed Life Sci. 2009;877(8-9):671-679.
• 22. Zick SM, Djuric Z, Ruffin MT, et al. Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthyhuman subjects. Cancer Epidemiol Biomarkers Prev. 2008;17(8):1930-1936.
• 22. Zick SM, Djuric Z, Ruffin MT, et al. Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthyhuman subjects. Cancer Epidemiol Biomarkers Prev. 2008;17(8):1930-1936.
• 23. Yu Y, Zick S, Li X, Zou P, Wright B, Sun D. Examination of the pharmacokinetics of active ingredients of ginger in humans. The AAPS Journal. 2011;13(3):417-426.
• 23. Yu Y, Zick S, Li X, Zou P, Wright B, Sun D. Examination of the pharmacokinetics of active ingredients of ginger in humans. The AAPS Journal. 2011;13(3):417-426.
• 24. Jiang S, Wang N, Mi S. Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharm Drug Dispos. 2008; 29(9):529-537.
• 24. Jiang S, Wang N, Mi S. Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharm Drug Dispos. 2008; 29(9):529-537.
• 25. Menon V, Elgharib M, El-awady R, Ekram S. Ginger: From serving table to salient therapy. Food Biosci. 2021;41:100934.
• 25. Menon V, Elgharib M, El-awady R, Ekram S. Ginger: From serving table to salient therapy. Food Biosci. 2021;41:100934.
• 26. Ajith TA, Hema U, Aswathi S. Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity in rat. J Exp Ther Oncol. 2016;11(3):171-175.
• 26. Ajith TA, Hema U, Aswathi S. Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity in rat. J Exp Ther Oncol. 2016;11(3):171-175.
• 27. AL-Sharif MMZ. Effect of therapeutic ginger on genotoxic of taxol drug (anti-cancer) in bone marrow cell of male mice. J Life Sci. 2011;5:897-905.
• 27. AL-Sharif MMZ. Effect of therapeutic ginger on genotoxic of taxol drug (anti-cancer) in bone marrow cell of male mice. J Life Sci. 2011;5:897-905.
• 28. Elshiekh AA, Elkolaly HR, Tawfeek NM, et al. Possible protective effect of ginger extract and beetroot juice against cisplatin induced testicular and cytogenetic toxicity in adult male albino rats. Egypt J Hosp Med. 2019;76(5):4046-4054.
• 28. Elshiekh AA, Elkolaly HR, Tawfeek NM, et al. Possible protective effect of ginger extract and beetroot juice against cisplatin induced testicular and cytogenetic toxicity in adult male albino rats. Egypt J Hosp Med. 2019;76(5):4046-4054.
• 29. El-Naggar MH, Mira A, Abdel Bar FM, Shimizu K, Amer MM, Badria FA. Synthesis, docking, cytotoxicity, and LTA 4 H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy. Bioorg Med Chem. 2017;25(3): 1277-1285.
• 29. El-Naggar MH, Mira A, Abdel Bar FM, Shimizu K, Amer MM, Badria FA. Synthesis, docking, cytotoxicity, and LTA 4 H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy. Bioorg Med Chem. 2017;25(3): 1277-1285.
• 30. Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: A systematic review of randomized clinical trials. Br J Anaesth. 2000;84(3):367-371.
• 30. Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: A systematic review of randomized clinical trials. Br J Anaesth. 2000;84(3):367-371.
• 31. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005;12(9):684-701.
• 31. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005;12(9):684-701.
• 32. Bryer E. A Literature review of the effectiveness of ginger in alleviating mild-to-moderate nausea and vomiting of pregnancy. J Midwifery Womens Health. 2005;50(1):1-3.
• 32. Bryer E. A Literature review of the effectiveness of ginger in alleviating mild-to-moderate nausea and vomiting of pregnancy. J Midwifery Womens Health. 2005;50(1):1-3.
• 33. Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Am Coll Obstet Gynecol. 2005;105(4):849-856.
• 33. Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Am Coll Obstet Gynecol. 2005;105(4):849-856.
• 34. Ding M, Leach M, Bradley H. The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: A systematic review. Women Birth. 2013;26(1):26-30.
• 34. Ding M, Leach M, Bradley H. The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: A systematic review. Women Birth. 2013;26(1):26-30.
• 35. Viljoen E, Visser J, Koen N, Musakiwa A. A Systematic review of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J. 2014;13(20):1-14.
• 35. Viljoen E, Visser J, Koen N, Musakiwa A. A Systematic review of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J. 2014;13(20):1-14.
• 36. Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy: A meta-analysis. J Am Board Fam Med. 2014;27(1):115-122.
• 36. Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy: A meta-analysis. J Am Board Fam Med. 2014;27(1):115-122.
• 37. White B. Ginger: An overview. Am Acad Fam Physicians. 2007;75(11):1689-1691.
• 37. White B. Ginger: An overview. Am Acad Fam Physicians. 2007;75(11):1689-1691.
• 38. Arslan M, Özdemir L. Kemoterapiye bağlı gelişen bulantı-kusmanın yönetiminde kullanılan tamamlayıcı tedavi yöntemleri. Türk Onkol Derg. 2015;30(2):82-89.
• 38. Arslan M, Özdemir L. Kemoterapiye bağlı gelişen bulantı-kusmanın yönetiminde kullanılan tamamlayıcı tedavi yöntemleri. Türk Onkol Derg. 2015;30(2):82-89.
• 39. Danwilai K, Konmun J, Sripanidkulchai BO, et al. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: A pilot study. Cancer Manag Res. 2017;9:11-18.
• 39. Danwilai K, Konmun J, Sripanidkulchai BO, et al. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: A pilot study. Cancer Manag Res. 2017;9:11-18.
• 40. Seidi J, Ebnerasooli S, Shahsawari S, et al. The influence of oral ginger before operation on nausea and vomiting after cataract sur-gery under general anesthesia: A double-blind placebo-controlled randomized clinical trial. Electron Physician. 2017;9(1):3508-3514.
• 40. Seidi J, Ebnerasooli S, Shahsawari S, et al. The influence of oral ginger before operation on nausea and vomiting after cataract sur-gery under general anesthesia: A double-blind placebo-controlled randomized clinical trial. Electron Physician. 2017;9(1):3508-3514.
• 41. Yadav S, Sharma K, Alam MA. Ginger medicinal uses and benefits. Eur J Pharm Med Res. 2016;3(7):127-135.
• 41. Yadav S, Sharma K, Alam MA. Ginger medicinal uses and benefits. Eur J Pharm Med Res. 2016;3(7):127-135.
• 42. Roy HJ, Lundy S, Eriksen C, Kalicki B. Ginger a potent root. Penningt Nutr Ser. 2007;(6):1-4.
• 42. Roy HJ, Lundy S, Eriksen C, Kalicki B. Ginger a potent root. Penningt Nutr Ser. 2007;(6):1-4.
• 43. Heimes K, Feistel B, Verspohl EJ. Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts. Eur J Pharmacol. 2009;624:58-65.
• 43. Heimes K, Feistel B, Verspohl EJ. Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts. Eur J Pharmacol. 2009;624:58-65.
• 44. Chakraborty D, Mukherjee A, Sikdar S, et al. [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicol Lett. 2012;210(1):34-43.
• 44. Chakraborty D, Mukherjee A, Sikdar S, et al. [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicol Lett. 2012;210(1):34-43.
• 45. Aryaeian N, Tavakkoli H. Ginger and its effects on inflammatory diseases. Adv Food Technol Nutr Sci Open J. 2015;1(4):97-101.
• 45. Aryaeian N, Tavakkoli H. Ginger and its effects on inflammatory diseases. Adv Food Technol Nutr Sci Open J. 2015;1(4):97-101.
• 46. Mashhadi NS, Ghiasvand R, Hariri M, et al. Effect of ginger and cinnamon intake on oxidative stress and exercise performance and body composition in Iranian female athletes. Int J Prev Med. 2013;4(1):31-35.
• 46. Mashhadi NS, Ghiasvand R, Hariri M, et al. Effect of ginger and cinnamon intake on oxidative stress and exercise performance and body composition in Iranian female athletes. Int J Prev Med. 2013;4(1):31-35.
• 47. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538.
• 47. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538.
• 48. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (zingiber officinale roscoe): A review of recent research. Clin Pharm. 2008;46:409-420.
• 48. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (zingiber officinale roscoe): A review of recent research. Clin Pharm. 2008;46:409-420.
• 49. J Jung HW, Yoon CH, Park KM, Han HS, Park YK. Hexane fraction of zingiberis rhizoma crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food Chem Toxicol. 2009;47(6):1190-1197.
• 49. J Jung HW, Yoon CH, Park KM, Han HS, Park YK. Hexane fraction of zingiberis rhizoma crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food Chem Toxicol. 2009;47(6):1190-1197.
• 50. Leach MJ, Kumar S. The clinical effectiveness of ginger (zingiber officinale) in adults with osteoarthritis. Int J Evid Based Healthc. 2008;6(3):311-320.
• 50. Leach MJ, Kumar S. The clinical effectiveness of ginger (zingiber officinale) in adults with osteoarthritis. Int J Evid Based Healthc. 2008;6(3):311-320.
• 51. Townsend EA, Siviski ME, Zhang Y, Xu C, Hoonjan B, Emala CW. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol. 2013;48(2):157-163.
• 51. Townsend EA, Siviski ME, Zhang Y, Xu C, Hoonjan B, Emala CW. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol. 2013;48(2):157-163.
• 52. Chen CX, Barrett B, Kwekkeboom KL. Efficacy of oral ginger (zingiber officinale) for dysmenorrhea: a systematic review and meta-analysis. Evidence-based Complement Altern Med. 2016. 53. Ewnetu Y, Lemma W, Birhane N. Synergetic antimicrobial effects of mixtures of Ethiopian honeys and ginger powder extracts on standard and resistant clinical bacteria isolates. Evidence-based Complement Altern Med. 2014;2014:17-19.
• 52. Chen CX, Barrett B, Kwekkeboom KL. Efficacy of oral ginger (zingiber officinale) for dysmenorrhea: a systematic review and meta-analysis. Evidence-based Complement Altern Med. 2016. 53. Ewnetu Y, Lemma W, Birhane N. Synergetic antimicrobial effects of mixtures of Ethiopian honeys and ginger powder extracts on standard and resistant clinical bacteria isolates. Evidence-based Complement Altern Med. 2014;2014:17-19.
• 54. Almotayri A, Jois M, Radcliffe J, Munasinghe M, Thomas J. The effects of red chilli, black pepper, turmeric, and ginger on body weight-A systematic review. Nutr Metabol. 2020;(19):1-8.
• 54. Almotayri A, Jois M, Radcliffe J, Munasinghe M, Thomas J. The effects of red chilli, black pepper, turmeric, and ginger on body weight-A systematic review. Nutr Metabol. 2020;(19):1-8.
• 55. Attari VE, Mahluji S, Jafarabadi MA, Ostadrahimi A. Effects of supplementation with ginger (zingiber officinale roscoe) on serum glucose, lipid profile and oxidative stress in obese women: A randomized, placebo-controlled clinical trial. Pharm Sci. 2015;21(4):184-191.
• 55. Attari VE, Mahluji S, Jafarabadi MA, Ostadrahimi A. Effects of supplementation with ginger (zingiber officinale roscoe) on serum glucose, lipid profile and oxidative stress in obese women: A randomized, placebo-controlled clinical trial. Pharm Sci. 2015;21(4):184-191.
• 56. Sang S, Snook HD, Tareq FS, Fasina Y. Precision research on ginger: the type of ginger matters. J Agric Food Chem. 2020;68(32):8517-8523.
• 56. Sang S, Snook HD, Tareq FS, Fasina Y. Precision research on ginger: the type of ginger matters. J Agric Food Chem. 2020;68(32):8517-8523.
• 57. Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. Fresh ginger (zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol. 2013;145(1):146-151.
• 57. Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. Fresh ginger (zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol. 2013;145(1):146-151.
• 58. Stanisiere J, Mousset PY, Lafay S. How safe is ginger rhizome for decreasing nausea and vomiting in women during early pregnancy? Foods. 2018;7(50):1-29.
• 58. Stanisiere J, Mousset PY, Lafay S. How safe is ginger rhizome for decreasing nausea and vomiting in women during early pregnancy? Foods. 2018;7(50):1-29.
• 59. Chrubasik S, Pittler MH, Eberhart L, et al. Addendum to a recent systematic review on ginger [multiple letters]. Forsch Komplementarmed Klass Naturheilkd. 2005;46:168-169.
• 59. Chrubasik S, Pittler MH, Eberhart L, et al. Addendum to a recent systematic review on ginger [multiple letters]. Forsch Komplementarmed Klass Naturheilkd. 2005;46:168-169.