Decellularized Extracellular Matrix in Kidney Tissue Engineering

Öz

Kidneys are organs that filter the body's waste products and perform vital functions. Kidney diseases, which cause various irreversible consequences, may occur due to the loss of function in these vital organs. Conditions such as chronic kidney disease (CKD), acute kidney disease (AKI), and kidney failure cause serious health problems and often require dialysis or kidney transplantation. Kidney tissue engineering offers innovative solutions to these problems and aims to reduce the need for organ transplantation. Decellularization technology involves removing cellular components from the extracellular matrix (ECM) of donor kidneys and refunctionalizing the ECM while preserving its native structure. This method shows promise in treating renal failure and has great potential in clinical applications.

Anahtar Kelimeler

• Kidney
• Tissue Engineering
• ECM
• Decellularization

Böbrek Doku Mühendisliğinde Hücresizleştirilmiş Hücre Dışı Matriks

Öz

Böbrekler, vücudun atık ürünlerini filtreleyen ve hayati işlevleri yerine getiren organlardır. Bu hayati organların fonksiyonlarını yitirmesi sonucu, geri döndürülemez ve çeşitli sonuçlar doğuran böbrek hastalıkları ortaya çıkabilmektedir. Kronik böbrek hastalığı (KBH), akut böbrek hastalığı (ABH) ve böbrek yetmezliği gibi durumlar, ciddi sağlık sorunlarına yol açmakta ve genellikle diyaliz veya böbrek organ nakli gerektirmektedir. Böbrek doku mühendisliği, bu sorunlara yenilikçi çözümler sunmakta ve organ nakline olan ihtiyacı azaltmayı hedeflemektedir. Hücresizleştirme teknolojisi, donör böbreklerden elde edilen hücrelerin extraselüler matrikslerinden (ECM) hücresel bileşenlerin uzaklaştırılması ve doğal ECM’nin korunarak yeniden fonksiyonelleştirilmesi sürecini içermektedir. Bu yöntem, böbrek yetmezliği tedavisinde umut vaat etmekte ve klinik uygulamalarda büyük potansiyel taşımaktadır.

Anahtar Kelimeler

• Böbrek
• Doku Mühendisliği
• ECM
• Hücresizleştirme

Kaynakça

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