Koronavirüs-19 Hastalığının Makro ve Moleküler Olarak İncelenmesi: Derleme

Yıl 2021, Cilt: 3 Sayı: 2, 110 - 166, 30.12.2021

Sami Karagöz , Erkan Özbay

Öz

Dünya Sağlık Örgütü verilerine göre, dünyada Ağustos 2021’in ortalarında (4.400.284’ü ölüm) 4.562.256.778, ülkemizde ise (53.891’i ölüm) 86.413.722 doğrulanmış Korona-virus 19 vakası bildirilmiştir.
Korona-virus 19, sitokin salıverilme ile karakterize olan şiddetli akut solunum sendromu oluşturur. Sitokin aracılı hiperinflamasyon olası tedavileri artan ölüm oranlarını azaltmak amacıyla ivedilikle araştırılmaktadır.

Günümüzde uzun vadeli etkileri bilinmemekle birlikte aşı uygulamaları yapılmasına rağmen, halen, Korona-viruslara karşı kesin onaylanmış bir tedavi uygulaması bulunmamaktadır. Deneyim ve bulunabilirliğe göre çok sayıda ilaç ampirik olarak kullanılmaktadır. Etkinliklerini ve güvenliğini gösteren çalışmalar hala yayınlanacaktır. Ancak bazı potansiyel tedaviler ve doğal tedaviler önerilmiştir. Çok sayıda aromatik bitki ve fitokimyasallar, koronaviruslar da dahil olmak üzere genetik ve işlevsel olarak farklı viruslara karşı terapötik kullanım için beklemektedir.

Türkiye, zengin etnomedikal deneyimi ve zengin florasıyla (% 34 endemik) bu konuda araştırma yapmak için yüksek potansiyele sahiptir. Yüzyıllardır influenzaya karşı kullanılan bitkiler etkili alternatifler sunabilir.

Anahtar Kelimeler

Koronavirus-19, sitokin, antiviral, TRP kanalları, NF-Kβ, STAT

Kaynakça

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