EFFECT OF MEAN PLATELET VOLUME ON MORTALITY IN MAINTENANCE HEMODIALYSIS PATIENTS

Yıl 2023, , 369 - 374, 13.07.2023

Sinan Kazan , Elif Dizen Kazan

https://doi.org/10.18229/kocatepetip.1156624

Öz

OBJECTIVE: Hemodialysis is the most preferred type of renal replacement therapy in patients with end-stage renal disease. Knowing the parameters affecting mortality in patients receiving maintenance hemodialysis treatment may increase the survival rate in this patient group. Mean platelet volume (MPV) is one of the parameters of the complete blood count. It has been shown that high MPV can increase the mortality rate in many diseases. In this study, we aimed to investigate the effect of MPV on the mortality rate in maintenance hemodialysis patients.
MATERIAL AND METHODS: The files of all patients who were started on maintenance dialysis treatment in our hospital between January 2010 and January 2020 were reviewed retrospectively. Demographic data and laboratory parameters of the patients were obtained from the patient files. For the MPV value, the mean of the MPV values in the routine complete blood count for the first 3 months after maintenance dialysis treatment was started. Patients who died and survived during the follow-up were compared in terms of MPV values.
RESULTS: The study was conducted with 129 patients. 24.8% (n= 32) of the patients died during follow-up. MPV of deceased patients was significantly higher than survived patients (11.14±1 vs. 10.12±0.8, p<0.001). The best MPV value for predicting mortality was found to be 10.73 (with 75% sensitivity and 81.4% specificity).
CONCLUSIONS: High MPV is an independent risk factor for mortality in maintenance hemodialysis patients. Tighter management of modifiable risk factors in hemodialysis patients with high MPV may improve their survival.

Anahtar Kelimeler

Hemodialysis, Mortality, Mean platelet volume

İDAME HEMODİYALİZ HASTALARINDA ORTALAMA TROMBOSİT HACMİ'NİN MORTALİTE ÜZERİNE ETKİSİ

Öz

AMAÇ: Hemodiyaliz son dönem böbrek hastalığı olan hastalarda en sık tercih edilen renal replasman tedavisi tipidir. İdame hemodiyaliz tedavisi alan hastalarda mortaliteyi etkileyen parametrelerin bilinmesi bu hasta grubunda sağkalımı artırabilir. Ortalama trombosit hacmi (MPV) tam kan sayımı parametrelerinden biridir. MPV yüksekliğinin birçok hastalıkta mortaliteyi artırabileceği gösterilmiştir. Bu çalışmamızda idame hemodiyaliz hastalarında MPV’nin mortalite üzerine etkisini araştırmayı amaçladık.
GEREÇ VE YÖNTEM: Ocak 2010 ve Ocak 2020 tarihleri arasında hastanemizde idame diyaliz tedavisine başlanan tüm hastaların dosyaları retrospektif olarak tarandı. Hastaların demografik verileri ve laboratuar parametrelerine hasta dosyalarından ulaşıldı. MPV değeri için idame diyaliz tedavisi başlanan ilk 3 ay rutin bakılan tam kan sayımındaki MPV değerlerinin ortalaması alındı. Takip süresince ölen ve yaşayan hastalar MPV değerleri açısından karşılaştırıldı.
BULGULAR: Çalışma 129 hasta ile yapıldı. Hastaların %24.8’i (n= 32) takipler süresince ölmüştü. Ölen hastaların MPV’si yaşayan hastalara göre anlamlı şekilde daha yüksekti (11.14±1’e karşı 10.12±0.8, p<0.001). Mortaliteyi öngörmek açısından en iyi MPV değeri 10.73 olarak bulundu (%75 sensitivite ve %81.4 spesifisite ile).
SONUÇ: Yüksek MPV idame hemodiyaliz hastalarında mortalite için bağımsız bir risk faktörüdür. MPV’si yüksek olan hemodiyaliz hastalarında değiştirilebilir risk faktörlerinin daha sıkı yönetilmesi sağkalımlarını artırabilir.

Anahtar Kelimeler

Hemodiyaliz, Mortalite, Ortalama trombosit hacmi

Kaynakça

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