HİSTOPATOLOJİK PARAMETRELER VE İNTRATÜMÖRAL LENFOSİTLER: ÜÇLÜ NEGATİF MEME KANSERİNDE SAĞKALIM SONUÇLARI İLE KORELASYON - KAPSAMLI RETROSPEKTİF BİR ANALİZ

Öz

AMAÇ: Üçlü-negatif meme kanseri (TNBC) agresif tümör davranışı ve sınırlı tedavi seçenekleriyle karakterize bir alt tiptir. Bu çalışmanın amacı TNBC'de yaş, patolojik evre, proliferatif indeks, tümör infiltre eden lenfositlerin (TIL) varlığı ve sağkalım sonuçları arasındaki ilişkiyi araştırmaktır. GEREÇ VE YÖNTEM: Üçlü negatif meme kanserli 31 hastanın tümör lamları ve blokları patoloji arşivinden alındı ve retrospektif olarak yeniden değerlendirildi. Hasta yaşı, tümörün histopatolojik alt tipi, tümör derecesi, lenf nodu derecesi, Ki-67 proliferasyon indeksi ve sağkalım arasındaki ilişki değerlendirildi. TIL'ler hafif, orta ve şiddetli olarak skorlandı ve sağkalım ile ilişkisi değerlendirildi. BULGULAR: Yaş ve tümör evresi ile ilgili olarak, anlamlı bir korelasyon bulunmamıştır (sırasıyla p=0,81 ve p=0,89). Bununla birlikte, N evresi analiz edildiğinde, 65 yaş ve üzeri hastaların daha yüksek bir oranının ileri N3 evresi meme kanseri göstermesiyle açık bir ilişki gözlenmiştir (p=0,000013). TIL'ler ile Ki-67 proliferatif indeks arasında anlamlı bir ilişki bulunmuş, yüksek TIL sergileyen vakalar aynı zamanda yüksek proliferatif indeks de göstermiştir (p=0,003). Ayrıca, artmış TIL konsantrasyonu TNBC hastalarında tedaviye olumlu yanıt ve genel sağkalımda iyileşme ile ilişkilendirilmiştir (p=0.001). SONUÇ: Bu bulgular, TNBC prognozunda yaş, patolojik evre, proliferatif indeks ve TIL varlığının dikkate alınmasının önemini vurgulamaktadır. TIL'lerin rutin histopatolojik incelemede değerlendirilmesi ve özellikle postmenopozal hastalarda patoloji raporlarına dahil edilmesi, gelecekteki çalışmalar için değerli bilgiler sağlayabilir ve tedavi kararlarını yönlendirebilir. TIL'leri hedefleyen immün modüle edici tedaviler üzerine ek araştırmalar, TNBC hastalarında sonuçları iyileştirmek için umut vaat edebilir.

Anahtar Kelimeler

• Üçlü negatif meme kanseri
• Tümör infiltre eden lenfositler
• Evre
• Sağkalım

Destekleyen Kurum

Yok

Proje Numarası

Yok

HISTOPATHOLOGICAL PARAMETERS AND INTRATUMORAL LYMPHOCYTES: CORRELATION WITH SURVIVAL OUTCOMES IN TRIPLE-NEGATIVE BREAST CANCER - A COMPREHENSIVE RETROSPECTIVE ANALYSIS

Öz

OBJECTIVE: Triple-negative breast cancer (TNBC) is a subtype characterized by aggressive tumor behavior and limited treatment options. This study aimed to investigate the relationship among age, pathological stage, proliferative index, presence of tumor infiltrating lymphocytes (TILs), and survival outcomes in TNBC. MATERIAL AND METHODS: Tumoral slides and blocks of 31 patients with triple negative breast cancer were retrieved from the pathology archive and retrospectively re-evaluated. The relationship among patient age, histopathological subtype of the tumor, tumor grade, lymph node grade, Ki-67 proliferation index and survival was evaluated. TILs were scored as mild, moderate and severe and the relationship with survival was evaluated. RESULTS: Regarding age and tumor stage, there was no significant correlation found (p=0,81 and p=0,89 respectively). However, when analyzing the N stage, a clear association was observed, with a higher proportion of patients aged 65 years or older displaying advanced N3 stage breast cancer (p=0.000013). A significant relationship was found between TILs and the Ki-67 proliferative index, with cases exhibiting high TILs also demonstrating a high proliferative index (p=0.003). Furthermore, increased TIL concentration was associated with a positive response to therapy and improved overall survival in TNBC patients (p=0.001). CONCLUSIONS: These findings emphasize the importance of considering age, pathological stage, proliferative index, and the presence of TILs in TNBC prognosis. Evaluation of TILs in routine histopathologic examination and inclusion in pathology reports, particularly in postmenopausal patients, could provide valuable information for future studies and guide treatment decisions. Additional research on immune-modulating therapies targeting TILs may hold promise for improving outcomes in TNBC patients.

Anahtar Kelimeler

• Triple negative breast cancer
• Tumor infiltrating lymphocytes
• Grade
• Survival

Proje Numarası

Yok

Kaynakça

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