Çocukluk Çağı Akut Lenfoblastik Lösemileri

Öz

Acute lymphoblastic leukemia is one of the most common group of cancers in childhood. It is more common in males. In the pathogenesis, some diseases with genetic disorders, exposure to chemical agents, and some chromosomal abnormalities have been thought to be responsible. The disease initially presents with nonspecific symptoms such as weakness, paleness, bleeding and fever. Diagnosis of the disease is made by physical examination and analiysis of peripheral blood and bone marrow biopsy. Risk-oriented protocols of chemotherapy reduces side effects while increasing survival rates. In recent years, 5-year survival rates have reached up to 80%in some studies

Anahtar Kelimeler

• Acute, leukemia, lymphoblastic

Çocukluk Çağı Akut Lenfoblastik Lösemileri

Öz

Akut lenfoblastik lösemi çocukluk çağının en çok görülen kanserlerinden birisidir. Erkek çocuklarda daha sık görülür. Etiyopatogenezinde genetik bozuklukla giden bazı hastalıklar, kimyasal ajanlara maruziyet ve bazı kromozomal anomaliler sorumlu tutulmuştur. Hastalık ilk olarak halsizlik, solukluk, kanama ve ateş gibi nonspesifik belirtilerle kendini gösterir. Fizik muayenede en çok lenfadenopati, hepatosplenomegali, solukluk ve cilt döküntüleri izlenir. Tanısı fizik muayene, periferik kan ve kemik iliği incelemesi ile konulur. Tedavide risk yönelimli kemoterapi protokolleri ile bir yandan yan etkiler azaltılırken diğer yandan yaşam oranları artırılmaktadır. Son yıllarda yapılan bazı çalışmalarda 5 yıllık sağ kalım oranları %80’ler düzeylerine çekilmiştir

Anahtar Kelimeler

• Çocuk, lösemi, lenfoblastik

Kaynakça

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