İmatinib Mesilat ile Tedavi Edilen Kronik Myeloid Lösemi Vakalarında Belirlenen Trizomi 8

Yıl 2005, Cilt: 6 Sayı: 2 , 7 - 10 , 01.08.2005

Erdinç Yüksel Mehmet Ali Özcan Zeynep Sercan Hale Şamlı Filiz Büyükkeçeci Mustafa Solak Meral SAKIZLI

https://izlik.org/JA59WG68ZM

Öz

Anahtar Kelimeler

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İmatinib Mesilat ile Tedavi Edilen Kronik Myeloid Lösemi Vakalarında Belirlenen Trizomi 8

https://izlik.org/JA59WG68ZM

Öz

Kronik myeloid lösemi vakalarında t(9;22)(q34;q11) translokasyonu sonucu Philadelphia (Ph) kromozomu oluşmakta ve bu translokasyon bcr-abl gen füzyonuna yol açmaktadır. İmatinib mesilat (STI571, Glivec) bcr-abl gen füzyonu sonucu sentezlenen bcr-abl tirozin kinaz proteininin inhibitörüdür. İleri faz kronik myeloid lösemi vakalarında en sık gözlenen sekonder karyotipik anomaliler, ikinci Ph, trizomi 8, izokromozom 17q ve trizomi 19 dur. Çok sayıda vakada Ph(-) ve Ph(+) hücrelerde klonal karyotipik anomaliler gelişmektedir. Bu çalışmada imatinib mesilat ile tedavi edilmiş biri Ph(-) trizomi 8, üçü de Ph(+) trizomi 8 olmak üzere dört vaka rapor edilmektedir

Anahtar Kelimeler

KML , İmatinib mesilat , Glivec , STI- 571 , Trizomi 8

Kaynakça

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