The Effects Of Erythropoietin On Liver Tissue In An Experimental Rat Model Of Septic Shock

Yıl 2015, , 178 - 184, 23.08.2015

Serdar Öter Adnan Şahin Dilek Burukoğlu Emine Sutken

https://doi.org/10.18229/ktd.81348

Öz

Background: Sepsis is a systemic response that develops
against infection and inflammation. These disorders remain the most important cause of mortality in intensive
care units.
Materal-Methods: In the present study, we used an experimental model of sepsis and septic shock by cecal ligation and perforation in rats to investigate the effects
of erythropoetin on hepatic functions and liver histology.
Findings: After treatment, we found statistically significant improvement in AST and ALT values at Erythropoietin treatment group. Also statistically significant improvements were observed in histological findings of liver
in rats treated with erythropoetin.
Results: In this study, we used erythropoietin to treat
the septic shock and ischemia-perfusion injury and inflammation. Data suggest that erythropoetin for the treatment of septic shock, as well as the liver damage resulting from the septic shock. Results of this study should
prompt future clinical studies. It seems likely that erythropoetin protects the organs against sepsis-induced oxidative organ injury.

Anahtar Kelimeler

erythropoetin, sepsis, rat, liver

Deneysel Septik Şok Modeli Oluşturulan Ratlarda Eritropoetinin Karaciğer Dokusu Üzerine Etkisi

Öz

Giriş: Sepsis, inflamasyon ve enfeksiyon tablolarına karşı verilen sistemik bir yanıttır. Yoğun bakım ünitelerindeki en önemli ölüm sebeplerindendir.

Materyal-Metot: Bu çalışmada ratlarda çekal ligasyon ve perforasyon modeli ile oluşturulan deneysel septik şok modeli kullanarak eritropoetinin hepatik fonksiyonlar ve histolojik bulguları üzerindeki etkilerini araştırdık.

Bulgular: Eritropoetin uygulanan tedavi grubuna ait sı- çanlarda tedavi sonrası AST ve ALT değerlerinde istatistiksel olarak anlamlı düzelme saptadık. Ayrıca eritropoietin ile tedavi edilen sıçanlardan karaciğerin histolojik yapı- sında istatistiksel olarak anlamlı düzelme saptadık.

Sonuç: Bu çalışmada septik şoktaki iskemi-perfüzyon hasarı ve inflamasyon tedavisinde eritropoetin kullandık. Veriler, septik şokun tedavisinde ve septik şoktan kaynaklanan karaciğer hasarında eritropoetin kullanımını önermektedir. Bu çalışmanın sonuçları, gelecekteki klinik çalışmaları teşvik edecektir. Eritropoetin, sepsis kaynaklı oksidatif hasardan organları korur gibi görünmektedir

Anahtar Kelimeler

Eritropoetin, sepsis, fare, karaciğer

Kaynakça

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