Insulin Resistance

Öz

Insulin resistance (IR) is an important cause ofnmorbidity. Sedentary lifestyle, dietary habitsnand heredity plays role. IR becomes more important when its relationship with obesity, hypertension, and hyperlipidemia is considered.nIt can be seen in 25% of the healthy population. IR is tried to be tolerated with hyperinsulinemia to achieve euglycemia. It is clinially importantnto identify the type 2 diabetesnrisk and /or cardiovascular disease. HOMA andnQUICKI are reliable methods to measure IR.nTreatment is modulation of life style including
diet. The medical treatment is a good optionnwhen diet and exercise do not work.

Anahtar Kelimeler

• Insulin resistance
• obesity
• hypertension
• type 2 diabetes

İnsülin Direnci

Öz

İnsülin direnci (İR), önemli bir morbidite nedenidir. Hareketsiz yaşam tarzı ve beslenme alışkanlığının yanında, genetik özellikler de rol oynamaktadır. İR, obezite, hipertansiyon ve hiperlipidemi ile ilişkisi nedeniyle ciddi önem taşımaktadır. Sağlıklı populasyonda % 25 oranında İR görülür. Bu direnç, öglisemiyi sağlayabilmek icin hiperinsülinemiyle karşılanmaya çalışılır. İR’nin gösterilmesi tip 2 diyabet ve/veya kardiyovasküler hastalık riskinin tanımlanması açısından klinik önem taşır. İR’nin ölçülmesinde HOMA ve QUICKI güvenilir metodlardır. Tedavi; diyet, egzersiz ve kilo kaybından oluşan yaşam tarzı değişikliğidir. Diyet ve egzersiz yeterli olmadığında ilaç tedavisi iyi bir seçenektir.

Anahtar Kelimeler

• İnsülin direnci
• obezite
• hipertansiyon
• tip 2 diyabet

Kaynakça

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