ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Ömer Ateş

doi:10.18229/kocatepetip.343171

ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Öz

AMAÇ: Alopesi Areata patogenezinde, değiş- miş T hücre aracılı bağışıklığın rol aldığını gösteren çok sayıda çalışma bulunmaktadır. Sitokinlerin ve kemokinlerin Alopesi Areata’nın immun sürecinde önemli rol oynamasından dolayı, Alopesi Areata’ya yatkınlık ile TNF-α-308G/A polimorfizmi arasındaki olası bağlantının Türk populasyonunda araştırılması amacıyla bu çalışma gerçekleştirildi.

GEREÇ VE YÖNTEM: Sunulan vaka kontrol çalışmasına 107 Alopesi Areata hastası ve 113 sağlıklı kontrol bireyi dahil edildi. TNF-α-308G/A polimorfizminin genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim Analizi (REA) yöntemleri ile gerçekleştirildi.

BULGULAR: Hasta ve kontrol gruplarında TNF-α-308 G/A genotiplerinin ve allel frekanslarının dağılımı arasında anlamlı bir bağlantı bulunamadı (p=0.673 ve p=0.177, sırasıyla). Benzer şekilde, TNF-α-308 G/A polimorfizmi ile Alopesi Areata’nın klinik bulguları arasında fark tespit edilemedi.

SONUÇ: Bu çalışma, TNF-α-308 G/A polimorfizminin Türk populasyonunda Alopesi Areata gelişiminde önemli bir rol oynamadığını göstermektedir.

Anahtar Kelimeler

Alopesi Areata,Polimorfizm,Genetik yatkınlık,TNF-α

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Ömer Ateş

Yayımlanma Tarihi

17 Ocak 2017

Gönderilme Tarihi

25 Şubat 2016

Kabul Tarihi

14 Nisan 2016

Yayımlandığı Sayı

Yıl 2017 Cilt: 18 Sayı: 1

DOI

https://doi.org/10.18229/kocatepetip.343171

IZ

https://izlik.org/JA57JC34XN

Kaynak Göster

RIS / Bibtex

APA

Ateş, Ö. (2017). ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Kocatepe Tıp Dergisi, 18(1), 7-12. https://doi.org/10.18229/kocatepetip.343171

AMA

1.Ateş Ö. ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. KTD. 2017;18(1):7-12. doi:10.18229/kocatepetip.343171

Chicago

Ateş, Ömer. 2017. “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”. Kocatepe Tıp Dergisi 18 (1): 7-12. https://doi.org/10.18229/kocatepetip.343171.

EndNote

Ateş Ö (01 Ocak 2017) ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Kocatepe Tıp Dergisi 18 1 7–12.

IEEE

[1]Ö. Ateş, “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”, KTD, c. 18, sy 1, ss. 7–12, Oca. 2017, doi: 10.18229/kocatepetip.343171.

ISNAD

Ateş, Ömer. “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”. Kocatepe Tıp Dergisi 18/1 (01 Ocak 2017): 7-12. https://doi.org/10.18229/kocatepetip.343171.

JAMA

1.Ateş Ö. ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. KTD. 2017;18:7–12.

MLA

Ateş, Ömer. “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”. Kocatepe Tıp Dergisi, c. 18, sy 1, Ocak 2017, ss. 7-12, doi:10.18229/kocatepetip.343171.

Vancouver

1.Ömer Ateş. ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. KTD. 01 Ocak 2017;18(1):7-12. doi:10.18229/kocatepetip.343171