AS A CARDIOVASCULAR RISK FACTOR IN GRAVES PATIENTS: MPV AND RDW

Öz

OBJECTIVE: In this study, we aimed to compare mean platelet volume (MPV) and red cell distribution width (RDW) values of graves patients compared to the healthy control group and to determine whether there was a relationship with cardiovascular risk factors.
MATERIAL AND METHODS: Fifty graves patients and 50 healthy control patients were evaluated retrospectively. Patients with diabetes mellitus (DM), iron deficiency anemia, chronic kidney injury, hypertension (HT), previous myocardial infarction, congestive heart failure, chronic inflammatory disease, malignancy and using antihyperlipidemic drugs were not included in the study. MPV and RDW values were recorded at the time of admission in the healthy control group and at the time of diagnosis in the graves group before the treatment was started. At the same time, LDL cholesterol (LDL-C), Hdl cholesterol (HDL-C), triglyceride (TG) values, smoking status, height, weight and body mass index (BMI) of both groups were analyzed retrospectively. The comparison of MPV and RDW values was evaluated by student-t test and the relationship with cardiovascular risk factors was evaluated by pearson correlation test.
RESULTS: There was no significant difference between MPV values of patients with Graves' disease who had not started medication and MPV values of healthy controls (p = 0.291). When the RDW values between two groups were examined, RDW values of the graves were significantly lower than the control group (p<0.05). When MPV and RDW values were compared between female patients with Graves and female patients in the control group; MPV and RDW values of female patients in the control group were significantly higher than female patients with graves (p = 0.047, p = 0.012, respectively). No correlation was found between smoking, advanced age and BMI and MPV, RDW values that are among Graves' cardiovascular risk factors. There was no correlation between LDL-C and RDW in the Graves group whereas there was a negative correlation between LDL-C and MPV (p = 0.016, r = -0.443).
CONCLUSIONS: MPV and RDW values, which are accepted as an indicator of inflammation and cardiovascular disease risk, were not correlated with cardiovascular risk factors in patients with graves.

Anahtar Kelimeler

• Graves, MPV, RDW, Cardiovascular risk factor

GRAVES HASTALARINDA KARDİYOVASKÜLER RİSK FAKTÖRÜ OLARAK: MPV VE RDW

Öz

AMAÇ: Bu çalışmada graves hastalarının sağlıklı kontrol grubuna göre ortalama trombosit hacmi (MPV) ve kırmızı kan hücresi dağılım genişliği (RDW) değerlerinin karşılaştırılması ve kardiyovasküler risk faktörleri ile ilişkisinin olup olmadığı amaçlandı.
GEREÇ VE YÖNTEM: 50 graves hastası ve 50 sağlıklı kontrol hasta retrospektif olarak incelendi. Diabetes mellitus (DM), demir eksikliği anemisi, kronik böbrek hasarı, hipertansiyon (HT), daha önce geçirilmiş myokard infarktüsü, konjestif kalp yetmezliği, kronik inflamatuar hastalığı, malignitesi olan ve antihiperlipidemik ilaç kullanan hastalar çalışmaya dahil edilmedi. Sağlıklı kontrol grubunun başvuru anında, graves grubunun ise tanı anında henüz tedavileri başlanmadan tam kan sayımının içinde rutinde bakılan MPV ve RDW değerleri kaydedildi. Aynı zamanda her iki grubun LDL kolesterol (LDL-C), Hdl kolesterol (HDL-C), trigliserid (TG) değerleri, sigara kullanıp kullanmadığı, boy, kilo ve vücut kitle indeksleri (VKİ) dosyalarından retrospektif olarak incelendi. MPV ve RDW değerlerinin karşılaştırılması student-t testi ile, kardiyovasküler risk faktörleri ile olan ilişkisi pearson korelasyon testi ile değerlendirildi.
BULGULAR: Graves hastası olup henüz ilaç tedavisi başlanmamış olan hastaların MPV değerleri ile sağlıklı kontrol grubunun MPV değerleri arasında anlamlı farklılık saptanmadı (p=0.291). İki grup arasında RDW değerlerine bakıldığında; graveslilerin RDW değerleri kontrol grubuna göre anlamlı düşük saptandı (p<0.05). Gravesli kadın hastalar ile kontrol grubundaki kadın hastalar MPV ve RDW değerleri açısından karşılaştırıldığında; kontrol grubundaki kadın hastaların MPV ve RDW değerleri gravesli kadın hastalara göre anlamlı yüksek saptandı (sırasıyla p=0.047, p=0.012). Gravesli hastalarda kardiyovasküler risk faktörlerinden sigara içimi, ileri yaş ve VKİ ile MPV, RDW değerleri arasında korelasyon saptanmadı. Gravesli grupta LDL-C ile RDW arasında korelasyon saptanmazken, LDL-C ile MPV arasında negatif korelasyon saptandı (p=0.016, r=-0.443).
SONUÇ: İnflamasyonun göstergesi ve kardiyovasküler hastalık risk göstergesi olarak kabul gören MPV ve RDW değerlerininin graves hastalarında kardiyovasküler risk faktörleri ile ilişkisi saptanmamıştır.

Anahtar Kelimeler

• Graves
• MPV
• RDW

Kaynakça

1. KAYNAKLAR
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