CLINICOPATHOLOGICAL CHARACTERISTICS OF 38 PATIENTS WITH STAGE I HIGH-GRADE SEROUS OVARIAN CANCER WHO RECEIVED ADJUVANT CHEMOTHERAPY

Öz

OBJECTIVE: Epithelial ovarian cancer is the most mortal among female cancers and is mostly diagnosed at an advanced stage It was aimed to investigate the clinicopathological features and recurrence patterns of patients who were diagnosed with stage 1 high-grade serous ovarian cancer and received adjuvant chemotherapy after surgery.
MATERIAL AND METHODS: Thirty-eight high-grade serous ovarian cancer patients treated in our clinic, stage 1 patient who underwent total abdominal hysterectomy + bilateral salpingooferectomy + pelvic-paraaortic lymph node dissection +/- omentectomy were included in the study.
RESULTS: Regarding the stage distribution of the patients, Stage IA 10 patients (26.3%), IB 7 patients (18.4), IC1 5 patients (13.2%), IC2 11 patients (28.9%), IC3 5 patients (13%) , 2). Recurrence developed in 11 (28.9%) of 38 patients. Regarding the recurring regions of the patients with recurrence, only pelvic 1 (2.6%), only the abdomen 8 (21.1%), while abdominal + pelvic recurrence developed in 1 (2.6) patient.
CONCLUSIONS: Serous histology is the most common subgroup of epithelial ovarian cancers and usually diagnosed at an advanced stage. The relapse rate is also high in patients diagnosed at an early stage.

Anahtar Kelimeler

• Serous ovarian cancer
• Early stage
• Recurrence.

ADJUVANT KEMOTERAPİ ALMIŞ EVRE I YÜKSEK DERECELİ SERÖZ OVER KANSERİ OLAN 38 HASTANIN KLİNİKOPATOLOJİK ÖZELLİKLERİ

Öz

AMAÇ: Epitelyal over kanseri kadın kanserleri arasında en mortal olan olup çoğunlukla ileri evrede tanı almaktadır. Evre I high-grade seröz over kanseri tanısı alan ve cerrahi sonrasında adjuvant kemoterapi alan hastaların klinikopatolojik özellikleri ve nüks paternlerinin araştırılması amaçlanmıştır.
GEREÇ VE YÖNTEM: Kliniğimizde tedavi görmüş olan 38 high-grade seröz over kanseri nedeniyle total abdominal histerektomi+bilateral salfingooferektomi+pelvik-paraaortik lenf nodu diseksiyon +/- omentektomi yapılan evre I hasta çalışmaya dahil edilmiştir.
BULGULAR: Hastaların evre dağılımına bakıldığında Evre IA 10 hasta (%26,3), IB 7 hasta (18,4), IC1 5 hasta (%13,2), IC2 11 hasta (%28,9), IC3 5 hasta (% 13,2) idi. 38 hastanın 11’inde (%28,9) rekürrens gelişti. Rekürrens gelişen hastaların nüks gelişen bölgelere bakıldığında sadece pelvik 1 (%2,6), sadece abdomen 8 (%21,1) iken abdominal + pelvik nüks 1 (2,6) hastada gelişti.
SONUÇ: Epitelyal over kanserleri arasında en sık görülen alt grup seröz histolojidir ve genelde ileri evrede tanı alırlar. Erken evrede tanı alan alan hastalarda da nüks oranı yüksektir.

Anahtar Kelimeler

• Seröz overyan kanser
• Erken evre
• Rekürrens.

Kaynakça

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