Osteoartritin Patogenezinde Rolü Olan Oksidatif Stres ve İnflamasyon Üzerine Hyalüronik Asidin Etkisi

Yıl 2010, Cilt: 11 Sayı: 1, 1 - 7, 01.04.2010

Sibel Koçar Çelik Ahmet Kahraman Gökhan Maralcan

Öz

Anahtar Kelimeler

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Osteoartritin Patogenezinde Rolü Olan Oksidatif Stres ve İnflamasyon Üzerine Hyalüronik Asidin Etkisi

Öz

Amaç: Osteoartrit (OA), deformite ve sakatlığa kadar giden bulgu ve semptomlara neden olarak hayatın yaşam kalitesini düşürmektedir. Hastanın yaşam kalitesini artırmak amacıyla uygulanan birçok tedavi semptomlara yöneliktir ve semptomatik iyileşme sağlarlar. Asıl kıkırdak yapımını azaltan ve yapımını artıran kıkırdak koruyucu tedaviye ihtiyaç vardır. Konroprotektif ilaçlar, hastalığını gerilemesini ve progresyonunun yavaşlamasını sağlarlar. Bu amaçla hyalüronik asit (HA ) preparatları kullanılmaktadır. Bu çalışmada osteoartritli (OA) hastalara hyalüronik asit (HA) uygulamasının OA’in patogenezinde rolü olan inflamasyon ve oksidatif stres üzerine etkilerini belirlemeyi amaçladık. Gereç ve yöntemler: Diz OA’li hastalara (n=8) intraartiküler olarak 3 doz HA uygulandı. HA uygulanmadan önce (kontrol grubu) ve 3. dozunun uygulanmasından sonra (tedavi grubu) enjektör ile eklem sıvısı elde edildi. Kontrol grubu ve tedavi grubu eklem sıvılarında lipit peroksidasyon ürünü olan malondialdehit düzeyi (MDA) , anti oksidan kapasiteyi gösteren redükte glutatyon (GSH) ve protein sülfidril (SH) grupları ile infilamatuar procesin göstergesi olarak tümör nekrozis faktör-α (TNF- α) düzeyleri ve protein karbonil içeriği çalışıldı. Bulgular: Tedavi grubunda MDA (p < 0.05), karbonil (p < 0.01) ve TNF-α (p < 0.01) düzeylerinin anlamlı olarak azaldığı, GSH (p < 0.05) düzeylerinin anlamlı olarak arttığı gözlendi. Protein SH gruplarının düzeylerinde de hafif artma saptandı. Ancak istatistiksel olarak anlamlı değildi (p > 0.05). Sonuç: Biz HA tedavisinin, eklem sıvısında azalmış MDA, karbonil ve TNF-α düzeyleri, artmış SH ve GSH düzeyleri ile ilişkili olarak OA’in patogenezinde pozitif etkileri olduğu düşünüyoruz

Anahtar Kelimeler

Osteoartrit, hyalüronik asit, inflamasyon, oksidatif stres

Kaynakça

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