Obezite ve Obezitenin Genetigi

Yıl 2006, Cilt: 7 Sayı: 3, 1 - 11, 01.12.2006

Mehmet Ali Sozen

Öz

Anahtar Kelimeler

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Obezite ve Obezitenin Genetigi

Öz

Obezite, kalp-damar hastalıkları ve Tip 2 diabet gibi komplikasyonlarıyla birlikte yüzyılımızda epidemik sınırlara yaklaşmaktadır. Günümüzde etkin bir tedavisi olmayan obezite, ciddi bir halk sağlığı problemidir. Obezite pozitif enerji bakiyesi sonucu ortaya çıkar ve genellikle beden kitle indeksi (BMI) ile ölçülür. İnsanlarda obezite ya monogenik sendromlar olarak veya multifaktöryel kalıtım modeline uymaktadirlar. Obezitenin monogenik versiyonları Leptin (LEP), Leptin reseptörü (LEPR), Melanocortin 4 reseptörü (MC4R) gibi belli genlerdeki mutasyonlar sonucu ortaya çıkar. Bunların sıklığı toplam olguların çok az bir kısmını oluşturur. Poligenik kalitim, multifaktöryel kalıtım modeli gösteren formları ise en yaygın versiyonudur ve genler, çevre, davranış ve hepsinin birbiriyle etkileşiminin bir sonucudur

Anahtar Kelimeler

Obezite, obezite genetigi, Melanocortin sistemi , mutasyon, aday genler

Kaynakça

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