Yıl 2006,
Cilt: 7 Sayı: 3, - , 01.12.2006
Öz
Anahtar Kelimeler
Kaynakça
- Olney JW, Newcomer JW, Farber NB. NMDA
- receptor hypofunction model of schizophrenia. J
- Psychiatr Res, 1999; 33:523-33.
- Javitt DC, Zukin SR. Recent advances in the
- phencyclidine model of schizophrenia. Am J
- Psychiatry, 1991; [48:1301-8.
- Corso TD, Sesma MA, Tenkova TI, Der TC,
- Wozniak DF, Farber NB, Olney JW. Multifocal brain
- damage induced by phencyclidine is augmented by
- pilocarpine. Brain Res, 1997; 75221-14.
- Haring R, Pellegrini-Giampietro DE, Zukin SR,
- Zukin RS, Scheideler MA. High efŞciency
- reconstitution of a phencyclidine/MK-801 receptor
- binding site solubilized from rat forebrain
- membranes. Mol Pharmacol. 1991; 402666-73.
- Ferrer-Montiel AV, Sun W, Montal M. Molecular
- design of the N—methyl-D-aspartate receptor binding
- site for phencyclidine and dizolcipine. Proc Natl
- Acad Sci U S A. 1995; 92:8021-5.
- Hoffman DC. Typical and atypical neuroleptics
- antagonize MK-801-induced locomotion and
- stereotypy in rats. J Neural Transm Gen Sect. 1992;89:1-10.
- Andine P, Widerrnark N, Axelsson R et al..
- Characterization of MK-SOl-induced behavior as a
- putative rat model of pschosis. JPET. 1999;290: 1393-1408.
- Mastropaolo J, Rosse RB, Deutsch Sl. Anabasine, a
- selective nicotinic acetylcholine receptor agonist,
- antagonizes MK-801-elicited mouse popping
- behavior, an animal model of schizophrenia. Behav
- Brain Res. 2004. 31; 53z419-22.
- Deutsch SI, Rosse RB, Billingslea EN, Bellack AS,
- Mastropaolo J. Modulation of MK-801-elicited
- mouse popping behavior by galantamine is complex
- and dose-dependent. Life Sci. 2003. 7318:2355-61. . Rung JP, Carlsson A, Ryden Markinhuhta K,
- Carlsson ML. (+)-MK—801 induced social withdrawal
- in rats; a model for negative symptoms of
- schizophrenia. Prog Neuropsychopharmacol Biol
- Psychiatry. 2005. 29:827-32. . Nakki R, Sharp F., Sagar SM. FOS expression in the
- brainstem and cerebellum following phencyclidine
- and MK801. J Neurosci Res. 1996; 43:203-12.
- Cortas, N. K., Wakid, N. W.:Determination of
- inorganic nitrate in serum and urine by a kinetic
- cadmium-reduction method. Clin Chem
- ;36:1440-1443. . Esterbauer H, Cheeseman KH. Determination of
- aldehydic lipid peroxidation products:
- Malonaldehyde and 4-hydroxynonenal. ln Methods in
- MK-801 Verilen Rat/arm Cerebellumun 'da Makromolekiiler Oksidasyon ve Cape ’nin Koruyucu Etkisi / 67 The Macromoleculer Oxıdation in Cerebellum of Rat Exposed To NIK-80] and The Protective Effect of Cape
- EnzymolOgy, V 186, Oxygen radicals in biological
- systems edited by Packer L, Glazer AN. Academic
- Press, California, 1990, pp 407—421. . Packer L, Glazer NA. Determination of Carbonyl
- Content in Oxidatively ModiŞed Proteins, Methods in
- Enzymology. California. 1990;186:464-479. . Lowry O, Rosenbraugh N, Farr L, Rondall R. Protein
- measurement with the folin-phenol reagent. J Biol
- Chem 1951;183:265-275. . Mahadik SP, Evans D, Lal H. Oxidative stress and ro—
- le of antioxidant and omega-3 essential fatty acid
- supplementation in schizophrenia. Prog
- Neuropsychopharmacol Biol Psychiatry. 2001; 25: 463-93. . Mahadik SP, Mukherjee S, Scheffer R, Correnti EE,
- Mahadik JS. Elevated plasma lipid peroxides at the
- onset of nonaffective psychosis. Biol Psychiatry.
- ; 43:674-9. .Mates JM, Perez-Gomez C, De Castro IN.
- Antioxidant enzymes and human diseases. Clin.
- Biocehmistry. 1999; 32: 595—603. . Akyol O, Herken H, Uz E, Fadillioglu E, Unal S,
- Sogut S, Ozyurt H, Savas HA. The indices of
- endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antioxidant imbalance. Prog
- Neuropsychopharmacol Biol Psychiatry. 2002; 262995-1005. . Ozyurt B, Sarsilmaz M, Akpolat N, Ozyurt H, Akyol
- O, Herken H, Kus I. The protective effects of omega
- fatty acids against MK-801—induced neurotoxicity
- in prefrontal cortex of rat. Neurochem Int. 2007; 50:196-202. . Herken H, Uz E, Ozyurt H, Akyol 0. Red blood cell
- nitric oxide levels in patients with schizophrenia.
- Schizophr Res. 2001; 52:289-90. . Özyurt B, Güleç M, Özyurt H, Ekici F, Atış Ö, Akbaş
- A. The effect of antioxidant caffeic acid phenethyl es
- ter (CAPE) on some enzyme activities in cisplatin
- induced neurotoxicity in rats. Eur J Gen Med. 2006; 3:167-172. .Sud'ina GF, Mirzoeva OK, Pushkareva MA,
- Korshunova GA, Sumbatyan NV, Varfolomeev SD.
- Caffeic acid phenethyl ester as a lipoxygenase
- inhibitor with antioxidant properties. FEBS Lett. 1993; 329:21-24.
- Kocatepe Tıp Dergisi, Cil 7 No: 3, Eylül 2006.
Yıl 2006,
Cilt: 7 Sayı: 3, - , 01.12.2006
Öz
Bu çalışmanın amacı MK-801 ile oluşan nörotoksisitede oksidatif stresin etkisini incelemek, oksidatif stresin önlenmesi ile prognozun düzelebileceğinin gösterilmesidir. MK-801 en nörotoksik NMDA reseptör antagonistlerinden biridir. Wistar Albino ratlar 3 gruba ayrıldı: l.grup: Kontrol, 2. grup: MK-80:l, 3. grup: MK— 801+CAPE. MK-80] beş gün intraperitoneal verildi. Tedavi grubuna MK—80l ’e maruzken CAPE verildi. Kontrol grubuna aynı sürede serum fizyolojik intraperitoneal verildi. 7 gün sonra ratlar dekapitasyonla öldürüldü. Serebellumları biyokimyasal analizler için çıkarıldı. Oksidatif stres parametresi olan Nitrik oksit (NO) yanı sıra Malondialdehit (MDA) ve Protein karbonil (PC) seviyeleri kontrol ile karşılaştırıldığında MK-801 grubu serebellumunda anlamlı artmıştı. CAPE ile tedavi edilen grupta NO, MDA ve PC seviyesi MK-80l grubu ile karşılaştırıldıgında ise anlamlı azaldı. Bu çalışmanın sonuçları serebellumda MK-801 ile oluşan nörotoksisitenin patogenesizinde oksidatif stresin önemli rolü olduğunu ortaya koydu. Bu deneysel çalışma aynı zamanda MK-80] ile oluşan nörotoksisite üzerine CAPE’nin koruyucu etkisi olabileceği yönünde bazı deliller sağlar
Kaynakça
- Olney JW, Newcomer JW, Farber NB. NMDA
- receptor hypofunction model of schizophrenia. J
- Psychiatr Res, 1999; 33:523-33.
- Javitt DC, Zukin SR. Recent advances in the
- phencyclidine model of schizophrenia. Am J
- Psychiatry, 1991; [48:1301-8.
- Corso TD, Sesma MA, Tenkova TI, Der TC,
- Wozniak DF, Farber NB, Olney JW. Multifocal brain
- damage induced by phencyclidine is augmented by
- pilocarpine. Brain Res, 1997; 75221-14.
- Haring R, Pellegrini-Giampietro DE, Zukin SR,
- Zukin RS, Scheideler MA. High efŞciency
- reconstitution of a phencyclidine/MK-801 receptor
- binding site solubilized from rat forebrain
- membranes. Mol Pharmacol. 1991; 402666-73.
- Ferrer-Montiel AV, Sun W, Montal M. Molecular
- design of the N—methyl-D-aspartate receptor binding
- site for phencyclidine and dizolcipine. Proc Natl
- Acad Sci U S A. 1995; 92:8021-5.
- Hoffman DC. Typical and atypical neuroleptics
- antagonize MK-801-induced locomotion and
- stereotypy in rats. J Neural Transm Gen Sect. 1992;89:1-10.
- Andine P, Widerrnark N, Axelsson R et al..
- Characterization of MK-SOl-induced behavior as a
- putative rat model of pschosis. JPET. 1999;290: 1393-1408.
- Mastropaolo J, Rosse RB, Deutsch Sl. Anabasine, a
- selective nicotinic acetylcholine receptor agonist,
- antagonizes MK-801-elicited mouse popping
- behavior, an animal model of schizophrenia. Behav
- Brain Res. 2004. 31; 53z419-22.
- Deutsch SI, Rosse RB, Billingslea EN, Bellack AS,
- Mastropaolo J. Modulation of MK-801-elicited
- mouse popping behavior by galantamine is complex
- and dose-dependent. Life Sci. 2003. 7318:2355-61. . Rung JP, Carlsson A, Ryden Markinhuhta K,
- Carlsson ML. (+)-MK—801 induced social withdrawal
- in rats; a model for negative symptoms of
- schizophrenia. Prog Neuropsychopharmacol Biol
- Psychiatry. 2005. 29:827-32. . Nakki R, Sharp F., Sagar SM. FOS expression in the
- brainstem and cerebellum following phencyclidine
- and MK801. J Neurosci Res. 1996; 43:203-12.
- Cortas, N. K., Wakid, N. W.:Determination of
- inorganic nitrate in serum and urine by a kinetic
- cadmium-reduction method. Clin Chem
- ;36:1440-1443. . Esterbauer H, Cheeseman KH. Determination of
- aldehydic lipid peroxidation products:
- Malonaldehyde and 4-hydroxynonenal. ln Methods in
- MK-801 Verilen Rat/arm Cerebellumun 'da Makromolekiiler Oksidasyon ve Cape ’nin Koruyucu Etkisi / 67 The Macromoleculer Oxıdation in Cerebellum of Rat Exposed To NIK-80] and The Protective Effect of Cape
- EnzymolOgy, V 186, Oxygen radicals in biological
- systems edited by Packer L, Glazer AN. Academic
- Press, California, 1990, pp 407—421. . Packer L, Glazer NA. Determination of Carbonyl
- Content in Oxidatively ModiŞed Proteins, Methods in
- Enzymology. California. 1990;186:464-479. . Lowry O, Rosenbraugh N, Farr L, Rondall R. Protein
- measurement with the folin-phenol reagent. J Biol
- Chem 1951;183:265-275. . Mahadik SP, Evans D, Lal H. Oxidative stress and ro—
- le of antioxidant and omega-3 essential fatty acid
- supplementation in schizophrenia. Prog
- Neuropsychopharmacol Biol Psychiatry. 2001; 25: 463-93. . Mahadik SP, Mukherjee S, Scheffer R, Correnti EE,
- Mahadik JS. Elevated plasma lipid peroxides at the
- onset of nonaffective psychosis. Biol Psychiatry.
- ; 43:674-9. .Mates JM, Perez-Gomez C, De Castro IN.
- Antioxidant enzymes and human diseases. Clin.
- Biocehmistry. 1999; 32: 595—603. . Akyol O, Herken H, Uz E, Fadillioglu E, Unal S,
- Sogut S, Ozyurt H, Savas HA. The indices of
- endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antioxidant imbalance. Prog
- Neuropsychopharmacol Biol Psychiatry. 2002; 262995-1005. . Ozyurt B, Sarsilmaz M, Akpolat N, Ozyurt H, Akyol
- O, Herken H, Kus I. The protective effects of omega
- fatty acids against MK-801—induced neurotoxicity
- in prefrontal cortex of rat. Neurochem Int. 2007; 50:196-202. . Herken H, Uz E, Ozyurt H, Akyol 0. Red blood cell
- nitric oxide levels in patients with schizophrenia.
- Schizophr Res. 2001; 52:289-90. . Özyurt B, Güleç M, Özyurt H, Ekici F, Atış Ö, Akbaş
- A. The effect of antioxidant caffeic acid phenethyl es
- ter (CAPE) on some enzyme activities in cisplatin
- induced neurotoxicity in rats. Eur J Gen Med. 2006; 3:167-172. .Sud'ina GF, Mirzoeva OK, Pushkareva MA,
- Korshunova GA, Sumbatyan NV, Varfolomeev SD.
- Caffeic acid phenethyl ester as a lipoxygenase
- inhibitor with antioxidant properties. FEBS Lett. 1993; 329:21-24.
- Kocatepe Tıp Dergisi, Cil 7 No: 3, Eylül 2006.
Toplam 77 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler-Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Aralık 2006 |
| Yayımlandığı Sayı | Yıl 2006 Cilt: 7 Sayı: 3 |
Kaynak Göster
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