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MK-801 Verilen Ratlarm Cerebellumun'da Makromolekiiler Oksidasyon ve Cape'nin Koruyucu Etkisi

Yıl 2006, Cilt: 7 Sayı: 3, - , 01.12.2006

Öz

Kaynakça

  • Olney JW, Newcomer JW, Farber NB. NMDA
  • receptor hypofunction model of schizophrenia. J
  • Psychiatr Res, 1999; 33:523-33.
  • Javitt DC, Zukin SR. Recent advances in the
  • phencyclidine model of schizophrenia. Am J
  • Psychiatry, 1991; [48:1301-8.
  • Corso TD, Sesma MA, Tenkova TI, Der TC,
  • Wozniak DF, Farber NB, Olney JW. Multifocal brain
  • damage induced by phencyclidine is augmented by
  • pilocarpine. Brain Res, 1997; 75221-14.
  • Haring R, Pellegrini-Giampietro DE, Zukin SR,
  • Zukin RS, Scheideler MA. High efŞciency
  • reconstitution of a phencyclidine/MK-801 receptor
  • binding site solubilized from rat forebrain
  • membranes. Mol Pharmacol. 1991; 402666-73.
  • Ferrer-Montiel AV, Sun W, Montal M. Molecular
  • design of the N—methyl-D-aspartate receptor binding
  • site for phencyclidine and dizolcipine. Proc Natl
  • Acad Sci U S A. 1995; 92:8021-5.
  • Hoffman DC. Typical and atypical neuroleptics
  • antagonize MK-801-induced locomotion and
  • stereotypy in rats. J Neural Transm Gen Sect. 1992;89:1-10.
  • Andine P, Widerrnark N, Axelsson R et al..
  • Characterization of MK-SOl-induced behavior as a
  • putative rat model of pschosis. JPET. 1999;290: 1393-1408.
  • Mastropaolo J, Rosse RB, Deutsch Sl. Anabasine, a
  • selective nicotinic acetylcholine receptor agonist,
  • antagonizes MK-801-elicited mouse popping
  • behavior, an animal model of schizophrenia. Behav
  • Brain Res. 2004. 31; 53z419-22.
  • Deutsch SI, Rosse RB, Billingslea EN, Bellack AS,
  • Mastropaolo J. Modulation of MK-801-elicited
  • mouse popping behavior by galantamine is complex
  • and dose-dependent. Life Sci. 2003. 7318:2355-61. . Rung JP, Carlsson A, Ryden Markinhuhta K,
  • Carlsson ML. (+)-MK—801 induced social withdrawal
  • in rats; a model for negative symptoms of
  • schizophrenia. Prog Neuropsychopharmacol Biol
  • Psychiatry. 2005. 29:827-32. . Nakki R, Sharp F., Sagar SM. FOS expression in the
  • brainstem and cerebellum following phencyclidine
  • and MK801. J Neurosci Res. 1996; 43:203-12.
  • Cortas, N. K., Wakid, N. W.:Determination of
  • inorganic nitrate in serum and urine by a kinetic
  • cadmium-reduction method. Clin Chem
  • ;36:1440-1443. . Esterbauer H, Cheeseman KH. Determination of
  • aldehydic lipid peroxidation products:
  • Malonaldehyde and 4-hydroxynonenal. ln Methods in
  • MK-801 Verilen Rat/arm Cerebellumun 'da Makromolekiiler Oksidasyon ve Cape ’nin Koruyucu Etkisi / 67 The Macromoleculer Oxıdation in Cerebellum of Rat Exposed To NIK-80] and The Protective Effect of Cape
  • EnzymolOgy, V 186, Oxygen radicals in biological
  • systems edited by Packer L, Glazer AN. Academic
  • Press, California, 1990, pp 407—421. . Packer L, Glazer NA. Determination of Carbonyl
  • Content in Oxidatively ModiŞed Proteins, Methods in
  • Enzymology. California. 1990;186:464-479. . Lowry O, Rosenbraugh N, Farr L, Rondall R. Protein
  • measurement with the folin-phenol reagent. J Biol
  • Chem 1951;183:265-275. . Mahadik SP, Evans D, Lal H. Oxidative stress and ro—
  • le of antioxidant and omega-3 essential fatty acid
  • supplementation in schizophrenia. Prog
  • Neuropsychopharmacol Biol Psychiatry. 2001; 25: 463-93. . Mahadik SP, Mukherjee S, Scheffer R, Correnti EE,
  • Mahadik JS. Elevated plasma lipid peroxides at the
  • onset of nonaffective psychosis. Biol Psychiatry.
  • ; 43:674-9. .Mates JM, Perez-Gomez C, De Castro IN.
  • Antioxidant enzymes and human diseases. Clin.
  • Biocehmistry. 1999; 32: 595—603. . Akyol O, Herken H, Uz E, Fadillioglu E, Unal S,
  • Sogut S, Ozyurt H, Savas HA. The indices of
  • endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antioxidant imbalance. Prog
  • Neuropsychopharmacol Biol Psychiatry. 2002; 262995-1005. . Ozyurt B, Sarsilmaz M, Akpolat N, Ozyurt H, Akyol
  • O, Herken H, Kus I. The protective effects of omega
  • fatty acids against MK-801—induced neurotoxicity
  • in prefrontal cortex of rat. Neurochem Int. 2007; 50:196-202. . Herken H, Uz E, Ozyurt H, Akyol 0. Red blood cell
  • nitric oxide levels in patients with schizophrenia.
  • Schizophr Res. 2001; 52:289-90. . Özyurt B, Güleç M, Özyurt H, Ekici F, Atış Ö, Akbaş
  • A. The effect of antioxidant caffeic acid phenethyl es
  • ter (CAPE) on some enzyme activities in cisplatin
  • induced neurotoxicity in rats. Eur J Gen Med. 2006; 3:167-172. .Sud'ina GF, Mirzoeva OK, Pushkareva MA,
  • Korshunova GA, Sumbatyan NV, Varfolomeev SD.
  • Caffeic acid phenethyl ester as a lipoxygenase
  • inhibitor with antioxidant properties. FEBS Lett. 1993; 329:21-24.
  • Kocatepe Tıp Dergisi, Cil 7 No: 3, Eylül 2006.

MK-801 Verilen Ratlarm Cerebellumun'da Makromolekiiler Oksidasyon ve Cape'nin Koruyucu Etkisi

Yıl 2006, Cilt: 7 Sayı: 3, - , 01.12.2006

Öz

Bu çalışmanın amacı MK-801 ile oluşan nörotoksisitede oksidatif stresin etkisini incelemek, oksidatif stresin önlenmesi ile prognozun düzelebileceğinin gösterilmesidir. MK-801 en nörotoksik NMDA reseptör antagonistlerinden biridir. Wistar Albino ratlar 3 gruba ayrıldı: l.grup: Kontrol, 2. grup: MK-80:l, 3. grup: MK— 801+CAPE. MK-80] beş gün intraperitoneal verildi. Tedavi grubuna MK—80l ’e maruzken CAPE verildi. Kontrol grubuna aynı sürede serum fizyolojik intraperitoneal verildi. 7 gün sonra ratlar dekapitasyonla öldürüldü. Serebellumları biyokimyasal analizler için çıkarıldı. Oksidatif stres parametresi olan Nitrik oksit (NO) yanı sıra Malondialdehit (MDA) ve Protein karbonil (PC) seviyeleri kontrol ile karşılaştırıldığında MK-801 grubu serebellumunda anlamlı artmıştı. CAPE ile tedavi edilen grupta NO, MDA ve PC seviyesi MK-80l grubu ile karşılaştırıldıgında ise anlamlı azaldı. Bu çalışmanın sonuçları serebellumda MK-801 ile oluşan nörotoksisitenin patogenesizinde oksidatif stresin önemli rolü olduğunu ortaya koydu. Bu deneysel çalışma aynı zamanda MK-80] ile oluşan nörotoksisite üzerine CAPE’nin koruyucu etkisi olabileceği yönünde bazı deliller sağlar

Kaynakça

  • Olney JW, Newcomer JW, Farber NB. NMDA
  • receptor hypofunction model of schizophrenia. J
  • Psychiatr Res, 1999; 33:523-33.
  • Javitt DC, Zukin SR. Recent advances in the
  • phencyclidine model of schizophrenia. Am J
  • Psychiatry, 1991; [48:1301-8.
  • Corso TD, Sesma MA, Tenkova TI, Der TC,
  • Wozniak DF, Farber NB, Olney JW. Multifocal brain
  • damage induced by phencyclidine is augmented by
  • pilocarpine. Brain Res, 1997; 75221-14.
  • Haring R, Pellegrini-Giampietro DE, Zukin SR,
  • Zukin RS, Scheideler MA. High efŞciency
  • reconstitution of a phencyclidine/MK-801 receptor
  • binding site solubilized from rat forebrain
  • membranes. Mol Pharmacol. 1991; 402666-73.
  • Ferrer-Montiel AV, Sun W, Montal M. Molecular
  • design of the N—methyl-D-aspartate receptor binding
  • site for phencyclidine and dizolcipine. Proc Natl
  • Acad Sci U S A. 1995; 92:8021-5.
  • Hoffman DC. Typical and atypical neuroleptics
  • antagonize MK-801-induced locomotion and
  • stereotypy in rats. J Neural Transm Gen Sect. 1992;89:1-10.
  • Andine P, Widerrnark N, Axelsson R et al..
  • Characterization of MK-SOl-induced behavior as a
  • putative rat model of pschosis. JPET. 1999;290: 1393-1408.
  • Mastropaolo J, Rosse RB, Deutsch Sl. Anabasine, a
  • selective nicotinic acetylcholine receptor agonist,
  • antagonizes MK-801-elicited mouse popping
  • behavior, an animal model of schizophrenia. Behav
  • Brain Res. 2004. 31; 53z419-22.
  • Deutsch SI, Rosse RB, Billingslea EN, Bellack AS,
  • Mastropaolo J. Modulation of MK-801-elicited
  • mouse popping behavior by galantamine is complex
  • and dose-dependent. Life Sci. 2003. 7318:2355-61. . Rung JP, Carlsson A, Ryden Markinhuhta K,
  • Carlsson ML. (+)-MK—801 induced social withdrawal
  • in rats; a model for negative symptoms of
  • schizophrenia. Prog Neuropsychopharmacol Biol
  • Psychiatry. 2005. 29:827-32. . Nakki R, Sharp F., Sagar SM. FOS expression in the
  • brainstem and cerebellum following phencyclidine
  • and MK801. J Neurosci Res. 1996; 43:203-12.
  • Cortas, N. K., Wakid, N. W.:Determination of
  • inorganic nitrate in serum and urine by a kinetic
  • cadmium-reduction method. Clin Chem
  • ;36:1440-1443. . Esterbauer H, Cheeseman KH. Determination of
  • aldehydic lipid peroxidation products:
  • Malonaldehyde and 4-hydroxynonenal. ln Methods in
  • MK-801 Verilen Rat/arm Cerebellumun 'da Makromolekiiler Oksidasyon ve Cape ’nin Koruyucu Etkisi / 67 The Macromoleculer Oxıdation in Cerebellum of Rat Exposed To NIK-80] and The Protective Effect of Cape
  • EnzymolOgy, V 186, Oxygen radicals in biological
  • systems edited by Packer L, Glazer AN. Academic
  • Press, California, 1990, pp 407—421. . Packer L, Glazer NA. Determination of Carbonyl
  • Content in Oxidatively ModiŞed Proteins, Methods in
  • Enzymology. California. 1990;186:464-479. . Lowry O, Rosenbraugh N, Farr L, Rondall R. Protein
  • measurement with the folin-phenol reagent. J Biol
  • Chem 1951;183:265-275. . Mahadik SP, Evans D, Lal H. Oxidative stress and ro—
  • le of antioxidant and omega-3 essential fatty acid
  • supplementation in schizophrenia. Prog
  • Neuropsychopharmacol Biol Psychiatry. 2001; 25: 463-93. . Mahadik SP, Mukherjee S, Scheffer R, Correnti EE,
  • Mahadik JS. Elevated plasma lipid peroxides at the
  • onset of nonaffective psychosis. Biol Psychiatry.
  • ; 43:674-9. .Mates JM, Perez-Gomez C, De Castro IN.
  • Antioxidant enzymes and human diseases. Clin.
  • Biocehmistry. 1999; 32: 595—603. . Akyol O, Herken H, Uz E, Fadillioglu E, Unal S,
  • Sogut S, Ozyurt H, Savas HA. The indices of
  • endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antioxidant imbalance. Prog
  • Neuropsychopharmacol Biol Psychiatry. 2002; 262995-1005. . Ozyurt B, Sarsilmaz M, Akpolat N, Ozyurt H, Akyol
  • O, Herken H, Kus I. The protective effects of omega
  • fatty acids against MK-801—induced neurotoxicity
  • in prefrontal cortex of rat. Neurochem Int. 2007; 50:196-202. . Herken H, Uz E, Ozyurt H, Akyol 0. Red blood cell
  • nitric oxide levels in patients with schizophrenia.
  • Schizophr Res. 2001; 52:289-90. . Özyurt B, Güleç M, Özyurt H, Ekici F, Atış Ö, Akbaş
  • A. The effect of antioxidant caffeic acid phenethyl es
  • ter (CAPE) on some enzyme activities in cisplatin
  • induced neurotoxicity in rats. Eur J Gen Med. 2006; 3:167-172. .Sud'ina GF, Mirzoeva OK, Pushkareva MA,
  • Korshunova GA, Sumbatyan NV, Varfolomeev SD.
  • Caffeic acid phenethyl ester as a lipoxygenase
  • inhibitor with antioxidant properties. FEBS Lett. 1993; 329:21-24.
  • Kocatepe Tıp Dergisi, Cil 7 No: 3, Eylül 2006.
Toplam 77 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler-Araştırma Yazıları
Yazarlar

Birsen Ozyurt Bu kişi benim

Huseyin Ozyurt Bu kişi benim

Fatih Ekici Bu kişi benim

Hasan Erdogan Bu kişi benim

Mustafa Sarsılmaz Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2006
Yayımlandığı Sayı Yıl 2006 Cilt: 7 Sayı: 3

Kaynak Göster

APA Ozyurt, B., Ozyurt, H., Ekici, F., Erdogan, H., vd. (2006). MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon ve Cape’nin Koruyucu Etkisi. Kocatepe Tıp Dergisi, 7(3). https://doi.org/10.18229/ktd.60395
AMA Ozyurt B, Ozyurt H, Ekici F, Erdogan H, Sarsılmaz M. MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon ve Cape’nin Koruyucu Etkisi. KTD. Aralık 2006;7(3). doi:10.18229/ktd.60395
Chicago Ozyurt, Birsen, Huseyin Ozyurt, Fatih Ekici, Hasan Erdogan, ve Mustafa Sarsılmaz. “MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon Ve Cape’nin Koruyucu Etkisi”. Kocatepe Tıp Dergisi 7, sy. 3 (Aralık 2006). https://doi.org/10.18229/ktd.60395.
EndNote Ozyurt B, Ozyurt H, Ekici F, Erdogan H, Sarsılmaz M (01 Aralık 2006) MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon ve Cape’nin Koruyucu Etkisi. Kocatepe Tıp Dergisi 7 3
IEEE B. Ozyurt, H. Ozyurt, F. Ekici, H. Erdogan, ve M. Sarsılmaz, “MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon ve Cape’nin Koruyucu Etkisi”, KTD, c. 7, sy. 3, 2006, doi: 10.18229/ktd.60395.
ISNAD Ozyurt, Birsen vd. “MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon Ve Cape’nin Koruyucu Etkisi”. Kocatepe Tıp Dergisi 7/3 (Aralık 2006). https://doi.org/10.18229/ktd.60395.
JAMA Ozyurt B, Ozyurt H, Ekici F, Erdogan H, Sarsılmaz M. MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon ve Cape’nin Koruyucu Etkisi. KTD. 2006;7. doi:10.18229/ktd.60395.
MLA Ozyurt, Birsen vd. “MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon Ve Cape’nin Koruyucu Etkisi”. Kocatepe Tıp Dergisi, c. 7, sy. 3, 2006, doi:10.18229/ktd.60395.
Vancouver Ozyurt B, Ozyurt H, Ekici F, Erdogan H, Sarsılmaz M. MK-801 Verilen Ratlarm Cerebellumun’da Makromolekiiler Oksidasyon ve Cape’nin Koruyucu Etkisi. KTD. 2006;7(3).

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