Nonobstruktif Azoospermik ve Şiddetli Oligozoospermik Erkeklerde Saptanan Kromozomal Anomaliler

Yıl 2005, Cilt: 6 Sayı: 1, 7 - 11, 01.04.2005

Hale Şamlı Mustafa Solak Necat İmirzalioğlu M. Murat Şamlı

Öz

Anahtar Kelimeler

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Nonobstruktif Azoospermik ve Şiddetli Oligozoospermik Erkeklerde Saptanan Kromozomal Anomaliler

Öz

Genetik faktörler erkek infertilitesi nedenleri arasında
önemli bir yer tutmaktadır. Sayısal ve yapısal
kromozomal düzensizliklere, sebebi bilinmeyen
oligozoospermik ve azoospermik olgularda sık rastlanmaktadır.
Bu çalışmada 1995-2005 yılları arasında
infertilite kıliniğine başvuran 383 azoospermik ve 436
şiddetli oligozoospermik toplam 819 Türk erkek incelemeye
alındı. Bir ay ara ile iki kez spermogram ve basal
hormon profilleri (FSH-Testosterone) çalışıldı. Tüm olguların
karyogram analizleri yapıldı.
İncelenen 383 azoospermik olgunun 47(%12,3) tanesinde,
436 oligozoospermik olgunun 20(%4,6) tanesinde
kromozomal düzensizlik tesbit edilmiştir. Azoospermik
olgularda tesbit edilen kromozomal düzensizliklerin
9(%19,1) tanesi otosomal ve 38(%80,9) tanesi gonozomal
kromozomlara ait bulunmuştur. Oligozoospermik olgularda
ise tespit edilen kromozomal düzensizliklerin 8(%40)
tanesi otozomal, 12(%60) tanesi gonozomal kromozomlara
aittir.
Erkekte infertiliteye neden olan genetik nedenlerin belirlenmesi
ve yardımcı üreme teknikleri kullanılarak elde edilecek
bu bireylere ait çocukların taşıyabilecekleri genetik
riskin saptanması amacıyla infertilite kliniğine başvuran
azoospermik, oligozoospermik infertil erkeklerde genetik
danışma verilmesi ve sitogenetik inceleme yapılması
doğru tanının konmasına yardımcı olacaktır.

Anahtar Kelimeler

Azoospermia, oligozoospermia, karyogram.

Kaynakça

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