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KORONER TROMBÜSÜN NEDEN OLDUĞU AKUT KORONER SENDROMLU ÜÇ OLGUNUN DEĞERLENDİRİLMESİ

Yıl 2021, Cilt 22, Sayı 6, 501 - 504, 18.10.2021
https://doi.org/10.18229/kocatepetip.571532

Öz

Akut miyokard infarktüsü olan hastalarda koroner trombüs, kan akımının azalmasına neden olur. Amacımız, üç olguda trombüs analizi yaparak, trombüsün neden olduğu koroner oklüzyon mekanizmalarının anlaşılmasına katkıda bulunmaktı. Olgulara koroner anjiyografi ile ST elevasyon tipi miyokard infarktüsü tanısı konuldu. Trombüslerde histopatolojik inceleme ve PTX3 (Pentraksin 3, bir akut faz proteini) ve CD68 (monosit ve makrofajlardan salınan bir sitokin) ile immünohistokimyasal boyama yapıldı. Ayrıca troponin ve PTX3 kan düzeyleri ölçüldü. PTX3 immün boyama skoru, tüm vakalarda yüksekti ve kan düzeyleri ile uyumlu değildi. PTX3 kan düzeyi normal olan vakada boyanma yoğunluğunun fazla olmasının, PTX3'ün hızlı lokal salınımı sonucu olabileceği düşünüldü. En yüksek PTX3 kan düzeyi olan vakada, bu artışı sağlayabilecek başka bir inflamatuar hastalık vardı. PTX3 ve CD68 immün boyamalarının, koroner trombüsün histopatolojik değerlendirilmesinde bir belirteç olarak kullanılabileceğini düşünüyoruz.

Kaynakça

  • 1. Ambrose JA, Winters SL, Stern A, et al. Angiographic morphology and the pathogenesis of unstable angina pectoris. J Am Coll Cardiol. 1985;5(3):609-16.
  • 2. Fuijkschot WW, Groothuizen WE, Appelman Y, et al. Inflammatory cell content of coronary thrombi is dependent on thrombus age in patients with ST-elevation myocardial infarction. J Cardiol. 2017;69(1):394-400.
  • 3. Bottazzi B, Bastone A, Doni A, et al. The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. J Leukoc Biol. 2006;79(5):909-12.
  • 4. Yunoki K, Naruko T, Sugioka K, et al. Thrombus aspiration therapy and coronary thrombus components in patients with acute ST-elevation myocardial infarction. J Atheroscler Thromb. 2013;20(6):524-37.
  • 5. Bonacina F, Baragetti A, Catapano AL, et al. Long pentraxin 3: experimental and clinical relevance in cardiovascular diseases. Mediators Inflamm. 2013;2013:725102.
  • 6. Savchenko A, Imamura M, Ohashi R, et al. Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions. J Pathol. 2008;215:48-55.
  • 7. Latini R, Maggioni AP, Peri G, et al. Lipid Assessment Trial Italian Network (LATIN) Investigators. Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2004;110(16):2349-54.
  • 8. Maugeri N, Rovere-Querini P, Slavich M, et al. Correction: Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. J Immunol. 2011;187(12):970- 9.
  • 9. Blasco A, Bellas C, Goicolea L, et al. Immunohistological Analysis of Intracoronary Thrombus Aspirate in STEMI Patients: ClinicalImplications of Pathological Findings. Rev Esp Cardiol (Engl Ed). 2017;70:170-7.
  • 10. Takashima A, Shimabukuro M, Tabata M, et al. Histopathological heterogeneity of in-stent restenosis in four coronary endarterectomy specimens. Cardiovasc Pathol . 2015;24:194-7.

EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS

Yıl 2021, Cilt 22, Sayı 6, 501 - 504, 18.10.2021
https://doi.org/10.18229/kocatepetip.571532

Öz

Coronary thrombus causes reduced blood flow in patients with acute myocardial infarction. Our aim was to to contribute to the understanding of the mechanisms of coronary occlusion caused by thrombus, evaluating the histopathological characteristics of thrombi in three cases. Cases were diagnosed with ST elevation type of myocardial infarction by coronary angiography. Histopathological analysis of thrombi as well as immunohistochemical staining with PTX3 (pentraxin 3, an acute phase protein) and CD68 (a cytokine released from monocyte and macrophages) were performed. Blood levels of troponin and PTX3 were also evaluated. The PTX3 immunostaining score was high in all cases but it was not consistent with its blood level. The high PTX3 staining intensity in the case with normal PTX3 blood level may be the result of rapid local release of PTX3. Case with highest PTX3 blood level had another inflammatory disease that could have driven this increase. We suggest that PTX3 and CD68 immunostainings can be used as a marker in the histopathological evaluation of coronary thrombus.

Kaynakça

  • 1. Ambrose JA, Winters SL, Stern A, et al. Angiographic morphology and the pathogenesis of unstable angina pectoris. J Am Coll Cardiol. 1985;5(3):609-16.
  • 2. Fuijkschot WW, Groothuizen WE, Appelman Y, et al. Inflammatory cell content of coronary thrombi is dependent on thrombus age in patients with ST-elevation myocardial infarction. J Cardiol. 2017;69(1):394-400.
  • 3. Bottazzi B, Bastone A, Doni A, et al. The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility. J Leukoc Biol. 2006;79(5):909-12.
  • 4. Yunoki K, Naruko T, Sugioka K, et al. Thrombus aspiration therapy and coronary thrombus components in patients with acute ST-elevation myocardial infarction. J Atheroscler Thromb. 2013;20(6):524-37.
  • 5. Bonacina F, Baragetti A, Catapano AL, et al. Long pentraxin 3: experimental and clinical relevance in cardiovascular diseases. Mediators Inflamm. 2013;2013:725102.
  • 6. Savchenko A, Imamura M, Ohashi R, et al. Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions. J Pathol. 2008;215:48-55.
  • 7. Latini R, Maggioni AP, Peri G, et al. Lipid Assessment Trial Italian Network (LATIN) Investigators. Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2004;110(16):2349-54.
  • 8. Maugeri N, Rovere-Querini P, Slavich M, et al. Correction: Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. J Immunol. 2011;187(12):970- 9.
  • 9. Blasco A, Bellas C, Goicolea L, et al. Immunohistological Analysis of Intracoronary Thrombus Aspirate in STEMI Patients: ClinicalImplications of Pathological Findings. Rev Esp Cardiol (Engl Ed). 2017;70:170-7.
  • 10. Takashima A, Shimabukuro M, Tabata M, et al. Histopathological heterogeneity of in-stent restenosis in four coronary endarterectomy specimens. Cardiovasc Pathol . 2015;24:194-7.

Ayrıntılar

Birincil Dil İngilizce
Konular Tıp
Yayınlanma Tarihi Ekim 2021
Bölüm Olgu Sunumu
Yazarlar

Aysel GÜVEN BAĞLA (Sorumlu Yazar)
ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ
0000-0002-1501-9324
Türkiye


Meltem İÇKİN GÜLEN
ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ
0000-0002-6364-8344
Türkiye


Bahadır KIRILMAZ
ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI
0000-0002-5929-1426
Türkiye


Ertuğrul ERCAN Bu kişi benim
İZMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI
0000-0003-0480-4738
Türkiye

Yayımlanma Tarihi 18 Ekim 2021
Yayınlandığı Sayı Yıl 2021, Cilt 22, Sayı 6

Kaynak Göster

Bibtex @olgu sunumu { kocatepetip571532, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {}, publisher = {Afyonkarahisar Sağlık Bilimleri Üniversitesi}, year = {2021}, volume = {22}, pages = {501 - 504}, doi = {10.18229/kocatepetip.571532}, title = {EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS}, key = {cite}, author = {Güven Bağla, Aysel and İçkin Gülen, Meltem and Kırılmaz, Bahadır and Ercan, Ertuğrul} }
APA Güven Bağla, A. , İçkin Gülen, M. , Kırılmaz, B. & Ercan, E. (2021). EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS . Kocatepe Tıp Dergisi , 22 (6) , 501-504 . DOI: 10.18229/kocatepetip.571532
MLA Güven Bağla, A. , İçkin Gülen, M. , Kırılmaz, B. , Ercan, E. "EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS" . Kocatepe Tıp Dergisi 22 (2021 ): 501-504 <https://dergipark.org.tr/tr/pub/kocatepetip/issue/65308/571532>
Chicago Güven Bağla, A. , İçkin Gülen, M. , Kırılmaz, B. , Ercan, E. "EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS". Kocatepe Tıp Dergisi 22 (2021 ): 501-504
RIS TY - JOUR T1 - EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS AU - Aysel Güven Bağla , Meltem İçkin Gülen , Bahadır Kırılmaz , Ertuğrul Ercan Y1 - 2021 PY - 2021 N1 - doi: 10.18229/kocatepetip.571532 DO - 10.18229/kocatepetip.571532 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 501 EP - 504 VL - 22 IS - 6 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.571532 UR - https://doi.org/10.18229/kocatepetip.571532 Y2 - 2020 ER -
EndNote %0 Kocatepe Tıp Dergisi EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS %A Aysel Güven Bağla , Meltem İçkin Gülen , Bahadır Kırılmaz , Ertuğrul Ercan %T EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS %D 2021 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 22 %N 6 %R doi: 10.18229/kocatepetip.571532 %U 10.18229/kocatepetip.571532
ISNAD Güven Bağla, Aysel , İçkin Gülen, Meltem , Kırılmaz, Bahadır , Ercan, Ertuğrul . "EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS". Kocatepe Tıp Dergisi 22 / 6 (Ekim 2021): 501-504 . https://doi.org/10.18229/kocatepetip.571532
AMA Güven Bağla A. , İçkin Gülen M. , Kırılmaz B. , Ercan E. EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS. KTD. 2021; 22(6): 501-504.
Vancouver Güven Bağla A. , İçkin Gülen M. , Kırılmaz B. , Ercan E. EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS. Kocatepe Tıp Dergisi. 2021; 22(6): 501-504.
IEEE A. Güven Bağla , M. İçkin Gülen , B. Kırılmaz ve E. Ercan , "EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS", Kocatepe Tıp Dergisi, c. 22, sayı. 6, ss. 501-504, Eki. 2021, doi:10.18229/kocatepetip.571532

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