COVID-19 HASTALARINDA RETİNA KALINLIĞININ OPTİK KOHERENS TOMOGRAFİ ANALİZİ

Yıl 2024, Cilt: 25 Sayı: 2, 241 - 245, 29.04.2024

Emin Serbülent Güçlü , Ömer Özer

https://doi.org/10.18229/kocatepetip.1197468

Öz

AMAÇ: Bu çalışmanın amacı COVID-19 enfeksiyonu olan hastalarda retinal değişikliklerin Optik Koherens Tomografi analizini yapmak ve bunları sağlıklı kontrollerle karşılaştırmaktır.
GEREÇ VE YÖNTEM: Bu amaçla, 1 Ekim 2020 ile 1 Mayıs 2021 tarihleri arasında kliniğimize başvuran, 18 ile 68 yaş arasında, COVID-19 pozitif 42 hasta (grup 1) ve 44 sağlıklı yetişkin (grup 2) çalışmaya alındı. Santral foveal kalınlık, koroidal kalınlık (subfoveal) ve peripapiller retina sinir lifi kalınlığı ölçülmüştür. Ölçümler merkezi foveada ve merkezi foveadan 1500 μm nazal ve 1500 μm temporal noktalarda gerçekleştirilmiştir.
BULGULAR: Gruplarda yaş ve cinsiyet dağılımı benzerdir (sırasıyla p=0,610 ve p=0,992). Ancak, santral foveal kalınlık (p<0,001), subfoveal koroid kalınlığı (p=0,001) ve peripapiller retina sinir lifi tabakası kalınlığı (p<0,001) iki grup arasında anlamlı olarak farklıydı.
SONUÇ: Sonuç olarak, polymerase chain reaction pozitif COVID-19 hastalarında santral fovea, foveal altı koroid ve peripapiller retina sinir lifi tabakası kalınlığı sağlıklı kontrollere kıyasla daha yüksektir. COVID-19'un neden olduğu sistemik ve lokal değişikliklerin patogenezini anlamak için, çok sayıda hasta alt grubu ile çok merkezli ve uzun süreli çalışmalar gereklidir.

OPTICAL COHERENCE TOMOGRAPHY ANALYSIS OF RETINAL THICKNESS IN COVID-19 PATIENTS

Öz

OBJECTIVE: The aim of this study was to perform Optical Coherence Tomography analysis of retinal changes in patients with COVID-19 infection and compare them with healthy controls.
MATERIAL AND METHODS: For this purpose, 42 COVID-19 positive patients (group 1) and 44 healthy adults (group 2), aged between 18 and 68 years, who were admitted to our clinic between October 1, 2020 and May 1, 2021, were included in the study. Central foveal thickness, choroidal thickness (subfoveal) and peripapillary retinal nerve fiber thickness were measured. Measurements were performed at the central fovea and at 1500 μm nasal and 1500 μm temporal points from the central fovea.
RESULTS: Age and gender distribution were similar in the groups (p=0.610 and p=0.992, respectively). However, central foveal thickness (p<0.001), subfoveal choroidal thickness (p=0.001) and peripapillary retinal nerve fiber layer thickness (p<0.001) were significantly different between the two groups.
CONCLUSIONS: In conclusion, central fovea, subfoveal choroidal and peripapillary retinal nerve fiber layer thickness were higher in polymerase chain reaction positive COVID-19 patients compared to healthy controls. To understand the pathogenesis of systemic and local changes caused by COVID-19, multicenter and long-term studies with a large number of patient subgroups are necessary.

Anahtar Kelimeler

COVID-19, Macula, Optical Coherence Tomography, Retina

Kaynakça

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