Hematological and Inflammatory Parameters Effective on Inflammation and Insulin Resistance in Obesity
Öz
Objective: Obesity is one of the predominant risk factors associated with insulin resistance (IR), type 2 diabetes, and many metabolic syndromes. In this
study, we aimed to investigate inflammatory parameters and their relationship with IR and blood groups in obese individuals.
Materials and Methods: The demographic characteristics, body mass index (BMI), biochemical parameters, hemogram values, and blood group types of
individuals in the obesity and control groups were recorded and compared.
Results: The mean age was 37.37±11.43 years in obese individuals and 41.8% (n=77) of them had IR. Neutrophil and monocyte counts of the obese individuals
with IR were significantly higher than those of the individuals without IR in the control and the obesity groups (p<0.001). The neutrophil/lymphocyte
ratio (NLR), the monocyte/high-density lipoprotein cholesterol ratio (MHR), and the systemic immune-inflammation index (SII) were significantly higher
in obese individuals with IR compared to obese individuals without IR. IR was more common and neutrophil ratios were significantly higher in obese individuals
with B blood type compared to those with O blood type (p=0.023).
Conclusion: We found that the values of hematological inflammatory parameters and the levels of NLR, MHR, and SII as indicators of systemic chronic
inflammation were increased in obese individuals with IR. We think that our study shows the relationship between inflammation due to excess adipose tissue
and the development of IR in obese individuals. We are of the opinion that future studies investigating this subject will help to develop processes for early
diagnosis and treatment.
Anahtar Kelimeler
Destekleyen Kurum
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Kaynakça
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