Investigation of the Risk of Sudden Cardiac Death Using Heart Rate Variation in Migraineurs
Abstract
Objective: Migraine is an episodic syndrome that results from dysfunction of the sympathetic nervous system and consists of various clinical features. The aim of our study is to evaluate the risk of sudden cardiac death and autonomic dysfunction in patients with migraine by heart rate turbulence (HRT) and heart rate variability (HRV). In addition, it is aimed to inform patients about their cardiovascular risks.
Material and Method: A total of 77 individuals, 35 of whom were chronic migraine sufferers and 42 healthy individuals, who were followed up by the neurology clinic over the age of 18 and under the age of 70, were included in this study. A 24-hour holter recording was made for all participants. Heart rate variability and heart rate turbulence parameters were calculated using European Society of Cardiology studies.
Findings: A significant difference was found between the migraine and control groups in terms of Tonset measurements (p=0.004). There was no statistically significant difference in terms of other variables.
Conclusion: Our findings showed that Tonset, one of the heart rate turbulence parameters, was associated with autonomic function in patients with migraine, whereas heart rate variability parameters were not associated with autonomic dysfunction in patients with migraine.
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- Laffitte C, Even C, Henry-Lebras F,et.al. Migraine and angina pectoris by coronary artery spasm. Headache 1996; 36: 332–4.
- Yakinci C, Mungen B, Er H,et.al. Autonomic nervous system func- tion in childhood migraine. Pediatr Int 1999; 41: 529–33.
- Kayıkçıoğlu M, Payzın S. Kalp hızı değişkenliği Türk Kardiyoloji Derneği Arş. 2001;29:238-45
- Pieper SJ, Hammill SC. Heart rate variability:tecnique and investigational applications in cardiovascular medicine. Mayo Clin Proc 1995;70:955-64
- Schwartz PJ, Zipes DP. Autonomic modulation of cardiac arrhymias. In:Zipes DP, Jalife I, eds. Cardiac Elektrophisology. From cell to Bedside. Philadelphia:W. B. Saunders, 2000;300-14
- Kleiger RE, Stein PK, Bosner MS,et.al. Time domain measurements of heart rate variability Cardiol Clin 1992;10:487-498
- Task Force of the European Society of Cardiology and North American Society of Pacing and Electrophysiology Heart rate variability:standarts of measurement, physiological interpretation, and clinical use. Circulation 1996;93:10431065
- Schmidt G, Malik M, Barthel P,et.al. Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet 1999; 353:1390– 1396.
- Lin LY, Lai LP, Lin JL,et.al. Tight mechanism correlation between heart rate turbulence and baroreflex sensitivity: sequential autonomic blockade analysis. J Cardiovasc Electrophysiol 2002; 13:427–431.
- Mari A. Watanabe, MD, Heart Rate Turbulence: a Review,PhDIndian Pacing and Electrophysiology Journal 2003;3(1):10-22