Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value

Didar Gürsoy; İclal Gürses; Vedia Bennu Gilan; Bahar Taşdelen; Ali Arıcan; Celalettin Tok

doi:10.17517/ksutfd.873338

TR EN

Over Karsinomlarında Östrojen, Progesteron Reseptörleri, C-Erb B-2, P53 ve BRCA1’in İmmünhistokimyasal Ekspresyonu ve Prognostik Önemleri

Öz

Çalışmamız ER, PR, C-erbB-2, p53 ve BRCA1 genlerinin immünohistokimyasal ekspresyonunu ve bunların klinikopatolojik özellikler ve prognostik önemi ile ilişkisini belirlemeyi amaçlamaktadır. Çalışmamıza Mersin Üniversitesi Tıp Fakültesi'nde 2002-2012 yılları arasında epitelyal OK tanısı konulan ve takip edilen 85 hasta dahil edildi. ER, PR, C-erbB-2, p53 ve BRCA1'in immünohistokimyasal ekspresyonu ve bunların klinikopatolojik parametrelerle ilişkisi değerlendirildi. Seröz karsinomlarda, ER ekspresyonu fallop tüpüne metastaz ile, PR ekspresyonu hastanın yaşı ile anlamlı şekilde ilişkiliydi, p53 ekspresyonu progresyonsuz sağkalım (PFS) ile anlamlı şekilde ilişkilendirildi, BRCA1'in sitoplazmik ekspresyonu genel sağkalım (OS) ve PFS ile anlamlı şekilde ilişkiliydi. Patogenez gruplarında 55 tümör tip 1 ve 30 tümör tip 2 idi. İki grup arasında ER, PR ve p53 ekspresyonları ile anlamlı korelasyonlar vardı. Çalışmamızda PR ve p53 seröz karsinomda prognostik faktörlerdi. Bu beş immünohistokimyasal belirtecin prognostik değerini belirlemek için her histolojik grupta daha fazla vaka içeren kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

ovarian cancer , hormone receptors , C-erb-B2 , P53 , BRCA1

Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value

Abstract

Our study aimed to determine immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 genes and their relationship with clinicopathological features and prognostic significance. The present study included 85 patients that were diagnosed with epithelial OC, treated and followed-up between 2002 and 2012 at Mersin University, Faculty of Medicine. Immunohistochemical expression of ER, PR, C-erbB-2, p53 and BRCA1 and their relation-ship with clinicopathological parameters were evaluated. In serous carcinomas, expression of ER was significantly associated with metastasis to the fallopian tube, expression of PR was significantly associated with patient’s age, expression of p53 was significantly associated with the progression-free survival (PFS), cytoplasmic expression of BRCA1 was significantly associated with the overall survival (OS) and PFS. In pathogenesis groups, 55 tumors were type 1, and 30 tumors were type 2. There were significant correlations with ER, PR and p53 expressions between the two groups. In our study, PR and p53 were prognostic factors in serous carcinoma. Extensive studies that contain more cases in each histological group are needed to determine the prognostic value of these five immunohistochemical markers.

Keywords

ovarian cancer , hormone receptors , C-erb-B2 , P53 , BRCA1

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Didar Gürsoy ^*
0000-0002-0674-7047
Türkiye

İclal Gürses
0000-0002-0115-2124
Türkiye

Vedia Bennu Gilan
0000-0002-7119-221X
Türkiye

Bahar Taşdelen
0000-0001-8146-4912
Türkiye

Ali Arıcan
0000-0002-6099-2000
Türkiye

Celalettin Tok
0000-0002-1197-6039
Türkiye

Yayımlanma Tarihi

21 Mart 2022

Gönderilme Tarihi

2 Şubat 2021

Kabul Tarihi

13 Nisan 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 17 Sayı: 1

DOI

https://doi.org/10.17517/ksutfd.873338

IZ

https://izlik.org/JA99PH79XE

AMA

1.Gürsoy D, Gürses İ, Gilan VB, Taşdelen B, Arıcan A, Tok C. Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value. KSÜ Tıp Fak Der. 2022;17(1):121-129. doi:10.17517/ksutfd.873338

Over Karsinomlarında Östrojen, Progesteron Reseptörleri, C-Erb B-2, P53 ve BRCA1’in İmmünhistokimyasal Ekspresyonu ve Prognostik Önemleri

Öz

Anahtar Kelimeler

Immunhistochemical Expression of Estrogen, Progesteron Receptors, C-Erb B-2, P53 and BRCA1 in Ovarian Carcinoma and Their Prognostic Value

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster