Kikuchi-Fujimoto disease is a rare, idiopathic and usually self-limiting disease caused by lymphadenitis. The main symptoms are lymphadenopathy and fever, and less frequent symptoms are night sweats, arthralgia, weight loss and rashes. A case of a 16 years old boy is presented. His complaints were cervical mass presenting for about three weeks, night sweats, weight loss and fatigue. Our aim is that in the differential diagnosis of fever and lymphadenopathy of unknown origin, diseases such as lymphoma and tuberculosis, as well as rare and mostly very benign Kikuchi-Fujimoto disease should be remembered.
Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia
with nuclear debris and phagocytosis. Nippon Ketsueki
Gakkai Zasshi. 1972;35:378–380.
Fujimoto Y, Kozima Y, Hamaguchi K. Cervical necrotizing lymphadenitis:
a new clinicopathological agent. Naika. 1972;20:920–
927.
Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier
L et al. Kikuchi-Fujimoto disease: retrospective study of
91 cases and review of the literature. Medicine (Baltimore).
2014;93(24):372–382.
Perry AM, Choi SM. Kikuchi-Fujimoto Disease: A Review. Arch
Pathol Lab Med. 2018;142(11):1341-1346.
Singh JM, Shermetaro CB. Kikuchi-Fujimoto disease in Michigan:
a rare case report and review of the literatüre. Clin Med Insights:
Ear, Nose and Throat. 2019;12:1-5.
Jamal AB. Kikuchi-Fujimoto disease. Clin Med Insights Arthritis
Musculoskelet Disord. 2012;5:63–6.
Lin HC, Su CY, Huang CC, Hwang CF, Chien CY. Kikuchi’s
disease: a review and analysis of 61 cases. Otolaryngology.
2003;128(5):650–3.
Lelii M, Senatore L, Amodeo I, Pinzani R, Torretta S, Fiori S et
al. Kikuchi-Fujimoto disease in children: two case reports and a
review of the literature. Ital J Pediatr. 2018;44:83.
Kucukardali Y, Solmazgul E, Kunter E, Oncul O, Yildirim S,
Kaplan M. Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin
Rheumatol. 2007;26(1):50-54.
Atwater AR, Longley BJ, Aughenbaugh WD. Kikuchi’s disease:
case report and systematic review of cutaneous and histopathologic
presentations. J Am Acad Dermatol. 2008;59:130–136.
Al Mosawi Z, Ebrahim B, Baik S, Madan W, Aljufairi E. Kikuchi-
Fujimoto Disease: Eleven pediatric cases and literature review.
Arch Rheumatol. 2020;35(2):303-307.
Deaver D, Naghashpour M, Sokol L. Kikuchi-Fujimoto disease
in the United States: three case reports and review of the literatüre.
Mediterr J Hematol Infect Dis. 2014;6(1):e2014001.
Lee BC, Patel R. Kikuchi-Fujimoto Disease: A 15-year analysis
at a children’ s hospital in the United States. Clin Pediatr.
2013;52:92-95.
Hutchinson CB, Wang E. Kikuchi-fujimoto disease. Arch Pathol
Lab Med. 2010;134(2):289–293.
Lin YW, Horiuchi H, Ueda I, Nambu M. Recurrent hemophagocytic
lymphohistiocytosis accompanied by Kikuchi’s disease.
Leuk Lymphoma. 2007;48:2447–2451.
Quadir A, Peacock K, Hsu P, Singh-Grewal D, Alexander S. A
familial case of Kikuchi-Fujimoto disease in dizygotic twins. Pediatr
Rheumatol Online J. 2020;18(1):62.
Özet
Kikuchi-Fujimoto hastalığı kendi kendini sınırlayan bir hastalık olup lenfadenitin oldukça nadir görülen sebeplerinden biridir. Başlıca semptomları lenfadenopati ve ateştir. Daha nadir olarak gece terlemesi, artralji, kilo kaybı ve cilt bulguları görülebilir. Bu yazıda üç haftadır mevcut olan servikal bölgede kitle,
gece terlemesi, kilo kaybı ve yorgunluk şikayetleri olan 16 yaşında erkek hasta sunulmuştur. Yazının amacı, nedeni belirsiz ateş ve lenfadenopatinin ayırıcı tanısında lenfoma ve tüberküloz gibi hastalıkların yanı sıra nadir görülen ve genellikle iyi seyirli olan Kikuchi-Fujimoto hastalığının da akılda tutulmasını
vurgulamaktır.
Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia
with nuclear debris and phagocytosis. Nippon Ketsueki
Gakkai Zasshi. 1972;35:378–380.
Fujimoto Y, Kozima Y, Hamaguchi K. Cervical necrotizing lymphadenitis:
a new clinicopathological agent. Naika. 1972;20:920–
927.
Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier
L et al. Kikuchi-Fujimoto disease: retrospective study of
91 cases and review of the literature. Medicine (Baltimore).
2014;93(24):372–382.
Perry AM, Choi SM. Kikuchi-Fujimoto Disease: A Review. Arch
Pathol Lab Med. 2018;142(11):1341-1346.
Singh JM, Shermetaro CB. Kikuchi-Fujimoto disease in Michigan:
a rare case report and review of the literatüre. Clin Med Insights:
Ear, Nose and Throat. 2019;12:1-5.
Jamal AB. Kikuchi-Fujimoto disease. Clin Med Insights Arthritis
Musculoskelet Disord. 2012;5:63–6.
Lin HC, Su CY, Huang CC, Hwang CF, Chien CY. Kikuchi’s
disease: a review and analysis of 61 cases. Otolaryngology.
2003;128(5):650–3.
Lelii M, Senatore L, Amodeo I, Pinzani R, Torretta S, Fiori S et
al. Kikuchi-Fujimoto disease in children: two case reports and a
review of the literature. Ital J Pediatr. 2018;44:83.
Kucukardali Y, Solmazgul E, Kunter E, Oncul O, Yildirim S,
Kaplan M. Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin
Rheumatol. 2007;26(1):50-54.
Atwater AR, Longley BJ, Aughenbaugh WD. Kikuchi’s disease:
case report and systematic review of cutaneous and histopathologic
presentations. J Am Acad Dermatol. 2008;59:130–136.
Al Mosawi Z, Ebrahim B, Baik S, Madan W, Aljufairi E. Kikuchi-
Fujimoto Disease: Eleven pediatric cases and literature review.
Arch Rheumatol. 2020;35(2):303-307.
Deaver D, Naghashpour M, Sokol L. Kikuchi-Fujimoto disease
in the United States: three case reports and review of the literatüre.
Mediterr J Hematol Infect Dis. 2014;6(1):e2014001.
Lee BC, Patel R. Kikuchi-Fujimoto Disease: A 15-year analysis
at a children’ s hospital in the United States. Clin Pediatr.
2013;52:92-95.
Hutchinson CB, Wang E. Kikuchi-fujimoto disease. Arch Pathol
Lab Med. 2010;134(2):289–293.
Lin YW, Horiuchi H, Ueda I, Nambu M. Recurrent hemophagocytic
lymphohistiocytosis accompanied by Kikuchi’s disease.
Leuk Lymphoma. 2007;48:2447–2451.
Quadir A, Peacock K, Hsu P, Singh-Grewal D, Alexander S. A
familial case of Kikuchi-Fujimoto disease in dizygotic twins. Pediatr
Rheumatol Online J. 2020;18(1):62.
Yıldırım S, Aşık A, Çobanoğlu Şimşek B, Bozkurt A. Kikuchi-Fujimoto Disease or Lymphoma?. KSÜ Tıp Fak Der. Temmuz 2022;17(2):240-243. doi:10.17517/ksutfd.900042