Araştırma Makalesi
BibTex RIS Kaynak Göster

Hemodializ Hastalarında Tedavi Uyumu, Akılcı İlaç Kullanımının Değerlendirilmesi ve Diyaliz Yeterliliğini Öngörücü Faktörler

Yıl 2023, Cilt: 18 Sayı: 1, 153 - 162, 16.03.2023
https://doi.org/10.17517/ksutfd.1176552

Öz

Amaç: Bu çalışmada hemodiyaliz hastalarında tedaviye uyum ve akılcı ilaç kullanımının değerlendirilmesi ve diyaliz yeterliliğini öngören faktörlerin
araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Bu, kesitsel tanımlayıcı bir çalışmadır. Veriler yüz yüze anketler ve hasta dosyaları incelenerek elde edildi. Hastalara Hastanede Yatan
Hasta Anketi ve Son Dönem Böbrek Hastalığı Uyum Anketi (ESRD-AQ) uygulandı. Diyaliz yeterliliği için Kt/V değeri kullanıldı. Elde edilen veriler incelenerek
Kt/V değeri ile ilişkilendirilebilecek değişkenler araştırılmıştır.
Bulgular: Çalışmaya toplam 145 hasta dahil edildi. Katılımcıların %69’u 51 yaş üstü ve %54.5’i erkekti. Medyan Kt/v değeri 1.38 idi (Q1=1.25; Q3=1.54).
İlaçlara gelince, Kt∕V≥1.2 olanların Kt/V<1.2 olan gruba göre daha fazla antihipertansif ajan, folik asit, vitamin B12 ve vitamin C kullandığı ancak daha az
levokarnitin kullandığı bulundu (p<0.05). Son Dönem Böbrek Yetmezliği Uyum Anketindeki Medyan Puanı 1150 idi (Q1=1050; Q3=1200). Toplam Uyum
Skoru Kt/V≥1.2 olan grupta istatistiksel olarak anlamlı derecede yüksek bulundu (p<0.05).
Sonuç: Araştırmaya katılan hastaların tedaviye uyum düzeylerinin oldukça yüksek olduğu belirlendi. Toplam uyum puanları arttıkça yeterli diyaliz alma
olasılığı artmaktaydı. Hastaların akılcı ilaç kullanımına ilişkin bilgi düzeyi uyumu etkiler. Bu çalışmada folik asit, C vitamini ve levokarnitin kullanımı
diyaliz yeterliliği ile ilişkilendirilmiştir.

Kaynakça

  • Tanrıverdi MH, Karadağ A, Hatipoğlu E.Ş. Kronik böbrek yetmezliği. Konuralp Medical J. 2010;2(2):27-32.
  • Seyahi N, Ates K, Suleymanlar G. Current status of renal replacement therapies in Turkey: Turkish society of nephrology registry 2015 summary report. Turk. Nephrol. Dial. Transp J. 2017;26(2):154-160.
  • KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 update. Am J Kidney Dis. Nov 2015;66(5):884-930.
  • Braun MM, Khayat M. Kidney Disease: End-Stage Renal Disease. FP Essent. Oct 2021;509:26-32.
  • Alikari V, Matziou V, Tsironi M, Theofilou P, Giannakopoulou N, Tzavella F et al. Patient Knowledge, Adherence, and Quality of Life in Hemodialysis. Adv Exp Med Biol. 2021;1337:259-272.
  • Alshamrani M, Almalki A, Qureshi M, Yusuf O, Ismail S. Polypharmacy and Medication-Related Problems in Hemodialysis Patients: A Call for Deprescribing. Pharmacy (Basel). 2018 Jul 25;6(3):76.
  • Cengiz Z, Ozkan M. Applying the health belief model to the rational use of drugs for hemodialysis patients: A randomized controlled trial. Patient Educ Couns. Mar 2022;105(3):679-685.
  • Kimura H, Kalantar-Zadeh K, Rhee CM, Streja E, Sy J. Polypharmacy and Frailty among Hemodialysis Patients. Nephron. 2021;145(6):624-632.
  • Organization WH. Rational use of medicines: progress in implementing the WHO medicines strategy. EB118/6. 2006;11.
  • Saran R, Bragg-Gresham JL, Rayner HC, Goodkin DA, Keen ML, Van Dijk PC et al. Nonadherence in hemodialysis: Associations with mortality, hospitalization, and practice patterns in the DOPPS. Kidney Int. 2003 Jul;64(1):254-262.
  • Leggat JE, Jr. Adherence with dialysis: a focus on mortality risk. Semin Dial. 2005;18(2):137-41.
  • Johansen KL, Chertow GM, Foley RN, Gilbertson DT, Herzog CA, Ishani A et al. US Renal Data System 2020 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2021;77(4):7-8.
  • Özkurt S, Sağlan Y, Gölgeli H, Sağlan R, Balcıoğlu H, Bilge U et al. Hemodiyaliz hastalarında tedaviye uyumun değerlendirilmesi. Ank. Med. J. 2017;17(4):275-283.
  • Karabulutlu EY, Yılmaz MÇ. Hemodiyaliz tedavisi alan bireylerin sıvı kısıtlamasına uyum düzeyleri. ACU Sağlık Bil Derg. 2019;(3):390-398.
  • Kim B, Kim J. Influence of uncertainty, depression, and social support on self-care compliance in hemodialysis patients. Ther Clin Risk Manag. 2019;15:1243.
  • Korkmaz Y. Hemodiyaliz hastalarının tedavi ve sıvı kısıtlamasına uyum, uyumsuzluk ve öz etkililik durumunun incelenmesi. Master Thesis. Sağlık Bilimleri Enstitüsü; 2016.
  • Denhaerynck K, Manhaeve D, Dobbels F, Garzoni D, Nolte C, De Geest S. Prevalence and consequences of nonadherence to hemodialysis regimens. Am J Crit Care. May 2007;16(3):222-235.
  • Cengiz Z, Ozkan M. Applying the health belief model to the rational use of drugs for hemodialysis patients: A randomized controlled trial. Patient Educ Couns. 2022;105(3):679-685.
  • Daniels GB, Robinson JR, Walker CA. Adherence to Treatment by African Americans Undergoing Hemodialysis. Nephrol Nurs J. 2018;45(6):561-568.
  • Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. May 2007;39(2):175-91. DOI: 10.3758/bf03193146.
  • Çobanoğlu A, Alkanat HÖ. Hastanede Yatan Hastaların Akılcı İlaç Kullanımına Yönelik Bilgi ve Davranışlarının İncelenmesi. J Nursology. 2019;22(1):33-40.
  • Health TMo. Webpage. Accessed 05.01, 2022. http://www.akilciilac.gov.tr/?p=718
  • Ok E, Kutlu FY. Son Dönem Böbrek Yetmezliği Uyum Ölçeği Türkçe Uyarlamasının Psikometrik Özellikleri. ACU Sağlık Bil Derg. 2019;10(3),427-437.
  • I. NKF-K/DOQI Clinical Practice Guidelines for Hemodialysis Adequacy: update 2000. Am J Kidney Dis. Jan 2001;37(1 Suppl 1):7-64.
  • Crawford PW, Lerma EV. Treatment Options for End Stage Renal Disease. Prim. Care. 2008/09/01/ 2008;35(3):407-432.
  • Bossola M, Pepe G, Picca A, Calvani R, Marzetti E. Treating symptoms to improve the quality of life in patients on chronic hemodialysis. Int Urol Nephrol 2019;51(5):885-887.
  • Alemayehu YH, Seylania K, Bahramnezhad F. The relationship between health literacy and quality of life among hemodialysis patients: An integrative review. Hum Antibodies. 2020;28:75-81.
  • Mateti U, Nagappa A, Attur R, Nagarapu S, Rangaswamy D. Impact of pharmaceutical care on the health-related quality of life among hemodialysis patients- A multicenter randomized controlled study. Original Article. Saudi J Kidney Dis Transpl. 2017;28(6):1293-1306.
  • Kanda H, Hirasaki Y, Iida T, Kanao-Kanda M, Toyama Y, Chiba T et al. Perioperative Management of Patients With End-Stage Renal Disease. J Cardiothorac Vasc Anesth. 2017;31(6):2251-2267.
  • Iwashita Y, Ohya M, Kunimoto S, Iwashita Y, Mima T, Negi S et al. A Survey of Drug Burden in Patients Undergoing Maintenance Hemodialysis in Japan. Intern Med. 2018;57(20):2937-2944.
  • Gao D, Jing S, Wu J, Wu G. Economic Burden and Medical Insurance Impact of the Different Dialysis for End-stage Renal Diseases. Iran J Public Health. 2018;47(11):1675-1680.
  • Yiğit V, Erdem R. Türkiye'de Diyaliz ve Böbrek Transplantasyonu Tedavisinin Maliyet Etkililik Analizi-Cost-Effectiveness Analysis of Dialysis and Kidney Transplantation Treatment in Turkey. Maku Sobed. 2016;1(13):182-205.
  • Kutner NG, Zhang R, McClellan WM, Cole SA. Psychosocial predictors of non-compliance in haemodialysis and peritoneal dialysis patients. Nephrol Dial Transplant. Jan 2002;17(1):93-99.
  • Ohya M, Iwashita Y, Kunimoto S, Yamamoto S, Mima T, Negi S et al. An analysis of medication adherence and patient preference in long-term stable maintenance hemodialysis patients in Japan. Intern. Med. 2019;58(18):2595-2603.
  • Sultan BO, Fouad AM, Zaki HM. Adherence to hemodialysis and medical regimens among patients with end-stage renal disease during COVID-19 pandemic: A cross-sectional study. BMC Nephrol. 2022;23(1):138.
  • Theofilou P, Togas C, Vasilopoulou C, Minos C, Zyga S, Tzitzikos G. The impact of Kt/V urea-based dialysis adequacy on quality of life and adherence in haemodialysis patients: a cross-sectional study in Greece. Health Psychol. Res. 2015;3(1).
  • Adequacy H. Work group. KDOQI clinical practice guideline for hemodialysis adequacy: 2015 update. Am J Kidney Dis. 2015;66(5):884-930.
  • Almeida FAA, Machado FC, Moura Junior JA, Guimarães AC. Global and cardiovascular mortality and risk factors in patients under hemodialysis treatment. Arq Bras Cardiol . 2010;94:201-206.
  • Stosovic MD, Petrovic MZ, Vujisic-Tesic BD, Stanojevic MLj, Simic-Ogrizovic SP, Jovanovic DB et al. Predictive value of echocardiography and its relation to Kt/V and anthropometric parameters in hemodialysis patients. Ren Fail. 2015;37(4):589-596.
  • Manns BJ, Johnson JA, Taub K, Mortis G, Ghali WA, Donaldson C. Dialysis Adequacy and Health Related Quality of Life in Hemodialysis Patients. ASAIO Journal. 2002;48(5).
  • Drüeke TB, Parfrey PS. Summary of the KDIGO guideline on anemia and comment: reading between the (guide) line (s). Kidney international. 2012;82(9):952-960.
  • Zha Y, Qian Q. Protein nutrition and malnutrition in CKD and ESRD. Nutrients. 2017;9(3):208.
  • Amouzou EK, Chabi NW, Adjalla CE, Rodriguez-Guéant RM, Feillet F, Villaume C et al. High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C→ T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa. The Am J Clin Nutr. 2004;79(4):619-624.
  • Çetinkaya R, Odabaş AR, Aktaş E, Selçuk Y. Kronik Hemodiyaliz Hastalarında Hemodiyaliz Yeterliliğinin Homosistein Düzeylerine Etkisi. Turk J Nephrol 2001;10(4):219-222.
  • Sales I, Bawazeer G, Tarakji AR, Ben Salha FK, Al-Deaiji NH, Saeed M et al. Assessment of Dietary Folate Intake and Pill Burden among Saudi Patients on Maintenance Hemodialysis. Int J Environ Res Public Health.2021;18(23):12710.
  • Ma L, Zhao S. Risk factors for mortality in patients undergoing hemodialysis: A systematic review and meta-analysis. Int J Cardiol. 2017;238:151-158.
  • de Mutsert R, Grootendorst DC, Indemans F, Boeschoten EW, Krediet RT, Dekker FW et al. Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition. J Ren Nutr. 2009;19(2):127-135.
  • Rebollo Rubio A, Morales Asencio JM, Pons Raventos ME. Biomarkers associated with mortality in patients undergoing dialysis. J Ren Care. 2017;43(3):163-174.
  • Galić G, Tomić M, Galesić K, Kvesić A, Soljić M, Mozetić V et al. Hypoalbuminemia and complication incidence in hemodialysed uremic patients. Coll Antropol . 2009;33(2):559-566.
  • Atabilen B, Yıldıran H. The Use of Carnitine in Hemodialysis Patients. Turk Neph Dial Transpl. 2017;26 (3):246-253.
  • Erdinç S. Hemodiyaliz hastalarında C vitamini infüzyonunun lipit profili, apolipoprotein B içeren lipoproteinlerin oksidasyonu ve serum paraoksonaz-arilesteraz enzim aktiviteleri üzerine etkisi. Master Thesis. Gazi University; 2007.
  • Deicher R, Ziai F, Bieglmayer C, Schillinger M, Hörl WH. Low total vitamin C plasma level is a risk factor for cardiovascular morbidity and mortality in hemodialysis patients. J Am Soc Nephrol. Jun 2005;16(6):1811-1818.
  • Galić G, Tomić M, Galesić K, Kvesić A, Soljić M, Mozetić V et al. Blood Pressure Control and Antihypertensive Treatment among Hemodialysis Patients-Retrospective Single Center Experience. Medicina (Kaunas). 2021;57(6).

Evaluation to Treatment Adherence, Rational Drug Use in Hemodialysis Patients and Predictive Factors on Dialysis Adequacy

Yıl 2023, Cilt: 18 Sayı: 1, 153 - 162, 16.03.2023
https://doi.org/10.17517/ksutfd.1176552

Öz

Objective: This study aimed to evaluate treatment adherence and rational drug use in hemodialysis patients and investigate predictive factors on dialysis
adequacy.
Materıals and Methods: This is a cross-sectional descriptive study. The data were obtained by examining face-to-face questionnaires and patient files. The
Hospitalized Patient Questionnaire and the End Stage Kidney Disease Compliance Questionnaire (ESRD-AQ) were administered to the patients. Kt/V was
used for dialysis proficiency. By examining the obtained data, the variables that can be associated with the Kt/V value were investigated.
Results: A total of 145 patients were included in the study. Sixty nine percent of the participants were over 51 years of age and 54.5% were male. Median
Kt/V level was 1.38 (Q1=1.25; Q3=1.54). As for the medications, those with Kt∕V≥1.2 were found to be using more antihypertensive agents, folic acid, vitamin
B12, and vitamin C but less levocarnitine concerning the group with Kt/V<1.2 (p<0.05). The Median Score on the End-Stage Renal Failure Adherence
Questionnaire was 1150 (Q1=1050; Q3=1200). Total Adherence Score was found to be statistically significantly higher in the group with Kt/V≥1.2 (p<0.05).
Conclusıon: It was determined that the level of treatment adherence of the patients participating in the study were considerably high. The probability of
receiving adequate dialysis increased as total adherence scores increased. The knowledge level of patients on rational drug use affects adherence. In this
study, folic acid, vitamin C, and levocarnitine were associated with dialysis adequacy.

Kaynakça

  • Tanrıverdi MH, Karadağ A, Hatipoğlu E.Ş. Kronik böbrek yetmezliği. Konuralp Medical J. 2010;2(2):27-32.
  • Seyahi N, Ates K, Suleymanlar G. Current status of renal replacement therapies in Turkey: Turkish society of nephrology registry 2015 summary report. Turk. Nephrol. Dial. Transp J. 2017;26(2):154-160.
  • KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 update. Am J Kidney Dis. Nov 2015;66(5):884-930.
  • Braun MM, Khayat M. Kidney Disease: End-Stage Renal Disease. FP Essent. Oct 2021;509:26-32.
  • Alikari V, Matziou V, Tsironi M, Theofilou P, Giannakopoulou N, Tzavella F et al. Patient Knowledge, Adherence, and Quality of Life in Hemodialysis. Adv Exp Med Biol. 2021;1337:259-272.
  • Alshamrani M, Almalki A, Qureshi M, Yusuf O, Ismail S. Polypharmacy and Medication-Related Problems in Hemodialysis Patients: A Call for Deprescribing. Pharmacy (Basel). 2018 Jul 25;6(3):76.
  • Cengiz Z, Ozkan M. Applying the health belief model to the rational use of drugs for hemodialysis patients: A randomized controlled trial. Patient Educ Couns. Mar 2022;105(3):679-685.
  • Kimura H, Kalantar-Zadeh K, Rhee CM, Streja E, Sy J. Polypharmacy and Frailty among Hemodialysis Patients. Nephron. 2021;145(6):624-632.
  • Organization WH. Rational use of medicines: progress in implementing the WHO medicines strategy. EB118/6. 2006;11.
  • Saran R, Bragg-Gresham JL, Rayner HC, Goodkin DA, Keen ML, Van Dijk PC et al. Nonadherence in hemodialysis: Associations with mortality, hospitalization, and practice patterns in the DOPPS. Kidney Int. 2003 Jul;64(1):254-262.
  • Leggat JE, Jr. Adherence with dialysis: a focus on mortality risk. Semin Dial. 2005;18(2):137-41.
  • Johansen KL, Chertow GM, Foley RN, Gilbertson DT, Herzog CA, Ishani A et al. US Renal Data System 2020 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2021;77(4):7-8.
  • Özkurt S, Sağlan Y, Gölgeli H, Sağlan R, Balcıoğlu H, Bilge U et al. Hemodiyaliz hastalarında tedaviye uyumun değerlendirilmesi. Ank. Med. J. 2017;17(4):275-283.
  • Karabulutlu EY, Yılmaz MÇ. Hemodiyaliz tedavisi alan bireylerin sıvı kısıtlamasına uyum düzeyleri. ACU Sağlık Bil Derg. 2019;(3):390-398.
  • Kim B, Kim J. Influence of uncertainty, depression, and social support on self-care compliance in hemodialysis patients. Ther Clin Risk Manag. 2019;15:1243.
  • Korkmaz Y. Hemodiyaliz hastalarının tedavi ve sıvı kısıtlamasına uyum, uyumsuzluk ve öz etkililik durumunun incelenmesi. Master Thesis. Sağlık Bilimleri Enstitüsü; 2016.
  • Denhaerynck K, Manhaeve D, Dobbels F, Garzoni D, Nolte C, De Geest S. Prevalence and consequences of nonadherence to hemodialysis regimens. Am J Crit Care. May 2007;16(3):222-235.
  • Cengiz Z, Ozkan M. Applying the health belief model to the rational use of drugs for hemodialysis patients: A randomized controlled trial. Patient Educ Couns. 2022;105(3):679-685.
  • Daniels GB, Robinson JR, Walker CA. Adherence to Treatment by African Americans Undergoing Hemodialysis. Nephrol Nurs J. 2018;45(6):561-568.
  • Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. May 2007;39(2):175-91. DOI: 10.3758/bf03193146.
  • Çobanoğlu A, Alkanat HÖ. Hastanede Yatan Hastaların Akılcı İlaç Kullanımına Yönelik Bilgi ve Davranışlarının İncelenmesi. J Nursology. 2019;22(1):33-40.
  • Health TMo. Webpage. Accessed 05.01, 2022. http://www.akilciilac.gov.tr/?p=718
  • Ok E, Kutlu FY. Son Dönem Böbrek Yetmezliği Uyum Ölçeği Türkçe Uyarlamasının Psikometrik Özellikleri. ACU Sağlık Bil Derg. 2019;10(3),427-437.
  • I. NKF-K/DOQI Clinical Practice Guidelines for Hemodialysis Adequacy: update 2000. Am J Kidney Dis. Jan 2001;37(1 Suppl 1):7-64.
  • Crawford PW, Lerma EV. Treatment Options for End Stage Renal Disease. Prim. Care. 2008/09/01/ 2008;35(3):407-432.
  • Bossola M, Pepe G, Picca A, Calvani R, Marzetti E. Treating symptoms to improve the quality of life in patients on chronic hemodialysis. Int Urol Nephrol 2019;51(5):885-887.
  • Alemayehu YH, Seylania K, Bahramnezhad F. The relationship between health literacy and quality of life among hemodialysis patients: An integrative review. Hum Antibodies. 2020;28:75-81.
  • Mateti U, Nagappa A, Attur R, Nagarapu S, Rangaswamy D. Impact of pharmaceutical care on the health-related quality of life among hemodialysis patients- A multicenter randomized controlled study. Original Article. Saudi J Kidney Dis Transpl. 2017;28(6):1293-1306.
  • Kanda H, Hirasaki Y, Iida T, Kanao-Kanda M, Toyama Y, Chiba T et al. Perioperative Management of Patients With End-Stage Renal Disease. J Cardiothorac Vasc Anesth. 2017;31(6):2251-2267.
  • Iwashita Y, Ohya M, Kunimoto S, Iwashita Y, Mima T, Negi S et al. A Survey of Drug Burden in Patients Undergoing Maintenance Hemodialysis in Japan. Intern Med. 2018;57(20):2937-2944.
  • Gao D, Jing S, Wu J, Wu G. Economic Burden and Medical Insurance Impact of the Different Dialysis for End-stage Renal Diseases. Iran J Public Health. 2018;47(11):1675-1680.
  • Yiğit V, Erdem R. Türkiye'de Diyaliz ve Böbrek Transplantasyonu Tedavisinin Maliyet Etkililik Analizi-Cost-Effectiveness Analysis of Dialysis and Kidney Transplantation Treatment in Turkey. Maku Sobed. 2016;1(13):182-205.
  • Kutner NG, Zhang R, McClellan WM, Cole SA. Psychosocial predictors of non-compliance in haemodialysis and peritoneal dialysis patients. Nephrol Dial Transplant. Jan 2002;17(1):93-99.
  • Ohya M, Iwashita Y, Kunimoto S, Yamamoto S, Mima T, Negi S et al. An analysis of medication adherence and patient preference in long-term stable maintenance hemodialysis patients in Japan. Intern. Med. 2019;58(18):2595-2603.
  • Sultan BO, Fouad AM, Zaki HM. Adherence to hemodialysis and medical regimens among patients with end-stage renal disease during COVID-19 pandemic: A cross-sectional study. BMC Nephrol. 2022;23(1):138.
  • Theofilou P, Togas C, Vasilopoulou C, Minos C, Zyga S, Tzitzikos G. The impact of Kt/V urea-based dialysis adequacy on quality of life and adherence in haemodialysis patients: a cross-sectional study in Greece. Health Psychol. Res. 2015;3(1).
  • Adequacy H. Work group. KDOQI clinical practice guideline for hemodialysis adequacy: 2015 update. Am J Kidney Dis. 2015;66(5):884-930.
  • Almeida FAA, Machado FC, Moura Junior JA, Guimarães AC. Global and cardiovascular mortality and risk factors in patients under hemodialysis treatment. Arq Bras Cardiol . 2010;94:201-206.
  • Stosovic MD, Petrovic MZ, Vujisic-Tesic BD, Stanojevic MLj, Simic-Ogrizovic SP, Jovanovic DB et al. Predictive value of echocardiography and its relation to Kt/V and anthropometric parameters in hemodialysis patients. Ren Fail. 2015;37(4):589-596.
  • Manns BJ, Johnson JA, Taub K, Mortis G, Ghali WA, Donaldson C. Dialysis Adequacy and Health Related Quality of Life in Hemodialysis Patients. ASAIO Journal. 2002;48(5).
  • Drüeke TB, Parfrey PS. Summary of the KDIGO guideline on anemia and comment: reading between the (guide) line (s). Kidney international. 2012;82(9):952-960.
  • Zha Y, Qian Q. Protein nutrition and malnutrition in CKD and ESRD. Nutrients. 2017;9(3):208.
  • Amouzou EK, Chabi NW, Adjalla CE, Rodriguez-Guéant RM, Feillet F, Villaume C et al. High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C→ T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa. The Am J Clin Nutr. 2004;79(4):619-624.
  • Çetinkaya R, Odabaş AR, Aktaş E, Selçuk Y. Kronik Hemodiyaliz Hastalarında Hemodiyaliz Yeterliliğinin Homosistein Düzeylerine Etkisi. Turk J Nephrol 2001;10(4):219-222.
  • Sales I, Bawazeer G, Tarakji AR, Ben Salha FK, Al-Deaiji NH, Saeed M et al. Assessment of Dietary Folate Intake and Pill Burden among Saudi Patients on Maintenance Hemodialysis. Int J Environ Res Public Health.2021;18(23):12710.
  • Ma L, Zhao S. Risk factors for mortality in patients undergoing hemodialysis: A systematic review and meta-analysis. Int J Cardiol. 2017;238:151-158.
  • de Mutsert R, Grootendorst DC, Indemans F, Boeschoten EW, Krediet RT, Dekker FW et al. Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition. J Ren Nutr. 2009;19(2):127-135.
  • Rebollo Rubio A, Morales Asencio JM, Pons Raventos ME. Biomarkers associated with mortality in patients undergoing dialysis. J Ren Care. 2017;43(3):163-174.
  • Galić G, Tomić M, Galesić K, Kvesić A, Soljić M, Mozetić V et al. Hypoalbuminemia and complication incidence in hemodialysed uremic patients. Coll Antropol . 2009;33(2):559-566.
  • Atabilen B, Yıldıran H. The Use of Carnitine in Hemodialysis Patients. Turk Neph Dial Transpl. 2017;26 (3):246-253.
  • Erdinç S. Hemodiyaliz hastalarında C vitamini infüzyonunun lipit profili, apolipoprotein B içeren lipoproteinlerin oksidasyonu ve serum paraoksonaz-arilesteraz enzim aktiviteleri üzerine etkisi. Master Thesis. Gazi University; 2007.
  • Deicher R, Ziai F, Bieglmayer C, Schillinger M, Hörl WH. Low total vitamin C plasma level is a risk factor for cardiovascular morbidity and mortality in hemodialysis patients. J Am Soc Nephrol. Jun 2005;16(6):1811-1818.
  • Galić G, Tomić M, Galesić K, Kvesić A, Soljić M, Mozetić V et al. Blood Pressure Control and Antihypertensive Treatment among Hemodialysis Patients-Retrospective Single Center Experience. Medicina (Kaunas). 2021;57(6).
Toplam 53 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Jale Akgöl 0000-0002-9163-3991

Elif Dizen Kazan 0000-0003-3550-0964

Sinan Kazan 0000-0001-7290-4680

Onur Tunca 0000-0003-1958-7617

Yayımlanma Tarihi 16 Mart 2023
Gönderilme Tarihi 17 Eylül 2022
Kabul Tarihi 3 Ekim 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 18 Sayı: 1

Kaynak Göster

AMA Akgöl J, Dizen Kazan E, Kazan S, Tunca O. Evaluation to Treatment Adherence, Rational Drug Use in Hemodialysis Patients and Predictive Factors on Dialysis Adequacy. KSÜ Tıp Fak Der. Mart 2023;18(1):153-162. doi:10.17517/ksutfd.1176552