Öz
Abstract
The most common diseases in the world are upper respiratory tract infections,resulting in substantial morbidity, mortality, and financial loss. Viruses are reported to be the most important pathogens involved. Several antiviral compounds have been developed. Cystus 052, a plant extract from a special variety of Cistusincanus that is rich in polymeric polyphenols, has been shown to exhibit antiviralactivity. In this article, the properties and efficacy of Cistus incanusis reviewed.
Anahtar Kelimeler
Cistus polyphenols upperrespiratory infections antiviral agents
Kaynakça
- Kaynaklar 1.Cos P, De Bruyne T, Hermans N, Apers S, Vanden BergheD, Vlietinck AJ. Proanthocyanidins in health care: currentand new trends. Curr Med Chem 2004; 11: 1345–59. 2.Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shima-mura T. Inhibition of the infectivity of influenza virus by teapolyphenols. Antiviral Res 1993; 21: 289–99. 3.Urquiaga I, Leighton F. Plant polyphenol antioxidants andoxidative stress. Biol Res 2000; 33: 55–64. 4.Ehrhardt C, Hrincius, ER, Korte V, Mazur I, Droebner K,et al. A polyphenol rich plant extract, CYSTUS052, exertsanti influenza virus activity in cell culture without toxicside effects or the tendency to induce viral resistance. Anti-viral Res 2007; 76: 38–47. 5.Kalusa U, Grigorova A, Kadeckib O, Jansenc JP, Kiese-wettera H, Radtkea H. Cistus incanus (CYSTUS052) fortreating patients with infection of the upper respiratorytract A prospective, randomised, placebo-controlled clini-cal study. Antiviral Research 2009: 84; 267–71. 6.Ulrich Kalus, Holger Kiesewetter, Hartmut Radtke. Effectof CYSTUS052 and green tea on subjective symptoms inpatients with infection of the upper respiratory tract.Phytother Res 2010: 24; 96–100. 7.Kiesewetter H. Cystussud zur lokalen Behandlung der Ton-sillopharyngitis. Erfahrungsheilkunge 2002; 11: 792–93. 8.Rebensburg S, Helfer M, Schneider M, Herwig Koppenstei-ner H, Eberle J, et al. Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targetsviral envelope proteins. Scientific Reports 2016; Feb 2; 6:20394. doi: 10.1038/srep20394. 9.Wittpahl G, Kölling-Speer I, Basche S, Herrmann E, Han-nig M, Speer K, et al. The polyphenolic composition of Cis-tus incanus herbal tea and its antibacterial and anti-adhe-rent activity against Streptococcus mutans. Planta Med2015; 81: 1727-35. 10.Kalliomaki M, Antoine JM, Herz U, Rijkers GT, Wells JM,Mercenier A. Guidance for substantiating the evidence forbeneficial effects of probiotics: prevention and managementof allergic diseases by probiotics. J Nutr 2010; 140: 713–21. 11.Singh A, Holvoet S, Mercenier A. Dietary polyphenols inthe prevention and treatment of allergic diseases. Clinical& Experimental Allergy, 2011; 41: 1346–59.
Öz
Öz
Dünyada en yaygın hastalık olan üst solunum yolu enfeksiyonları (ÜSYE) yüksek morbidite, mortalite ve ekonomik kayıplara yol açmaktadır. ÜSYE etiyolojisinde en sık saptanan patojenler viruslardır. Korunma ve tedavi amaçlı birçok antiviral özellikte madde geliştirilmiştir. Cystus 052, Cistus incanus bitkisinden elde edilen bir bitki özütü olup polimerik polifenollerden zengindir ve antiviral etkinliği gösterilmiştir. Bu yazıda Cistus incanus bitki özütünün özellikleri ve etkinliği değerlendirilmektedir.
Anahtar Kelimeler
Cistus polifenoller üst solunumyolu enfeksiyonları antiviralajanlar
Kaynakça
- Kaynaklar 1.Cos P, De Bruyne T, Hermans N, Apers S, Vanden BergheD, Vlietinck AJ. Proanthocyanidins in health care: currentand new trends. Curr Med Chem 2004; 11: 1345–59. 2.Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shima-mura T. Inhibition of the infectivity of influenza virus by teapolyphenols. Antiviral Res 1993; 21: 289–99. 3.Urquiaga I, Leighton F. Plant polyphenol antioxidants andoxidative stress. Biol Res 2000; 33: 55–64. 4.Ehrhardt C, Hrincius, ER, Korte V, Mazur I, Droebner K,et al. A polyphenol rich plant extract, CYSTUS052, exertsanti influenza virus activity in cell culture without toxicside effects or the tendency to induce viral resistance. Anti-viral Res 2007; 76: 38–47. 5.Kalusa U, Grigorova A, Kadeckib O, Jansenc JP, Kiese-wettera H, Radtkea H. Cistus incanus (CYSTUS052) fortreating patients with infection of the upper respiratorytract A prospective, randomised, placebo-controlled clini-cal study. Antiviral Research 2009: 84; 267–71. 6.Ulrich Kalus, Holger Kiesewetter, Hartmut Radtke. Effectof CYSTUS052 and green tea on subjective symptoms inpatients with infection of the upper respiratory tract.Phytother Res 2010: 24; 96–100. 7.Kiesewetter H. Cystussud zur lokalen Behandlung der Ton-sillopharyngitis. Erfahrungsheilkunge 2002; 11: 792–93. 8.Rebensburg S, Helfer M, Schneider M, Herwig Koppenstei-ner H, Eberle J, et al. Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targetsviral envelope proteins. Scientific Reports 2016; Feb 2; 6:20394. doi: 10.1038/srep20394. 9.Wittpahl G, Kölling-Speer I, Basche S, Herrmann E, Han-nig M, Speer K, et al. The polyphenolic composition of Cis-tus incanus herbal tea and its antibacterial and anti-adhe-rent activity against Streptococcus mutans. Planta Med2015; 81: 1727-35. 10.Kalliomaki M, Antoine JM, Herz U, Rijkers GT, Wells JM,Mercenier A. Guidance for substantiating the evidence forbeneficial effects of probiotics: prevention and managementof allergic diseases by probiotics. J Nutr 2010; 140: 713–21. 11.Singh A, Holvoet S, Mercenier A. Dietary polyphenols inthe prevention and treatment of allergic diseases. Clinical& Experimental Allergy, 2011; 41: 1346–59.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | makale |
| Yazarlar | |
| Yayımlanma Tarihi | 25 Ocak 2017 |
| Yayımlandığı Sayı | Yıl 2017 Cilt: 9 Sayı: 1 |
