Rekürren Aftöz Stomatitli Hastalarda Total Oksidan Durum, Total Antioksidan Durum ve Oksidatif Stres İndeksinin Değerlendirilmesi

Öz

Amaç: Çalışmamızda rekürren aftöz stomatitli (RAS) hastalarda total oksidan durum (TOS), total antioksidan durum (TAS) ve oksidatif stress indeksi (OSI) parametrelerini değerlendirmeye çalıştık. Yöntem: Dermatoloji polikliniğine oral ülser şikayeti ile başvuran ve RAS tanısı alan 23 kadın ve 17 erkek olmak üzere yaş ortalaması 29 olan toplam 40 hasta ile 33 kadın ve 16 erkek olmak üzere yaş ortalaması 24 olan 49 sağlıklı gönüllü çalışmaya dahil edildi. Bulgular: TOS ve OSI değerleri RAS grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulunmuştur. İki grup arasındaki TAS değerleri karşılaştırıldığında ise RAS grubuna ait TAS değeri ile kontrol grubuna ait TAS değeri arasında fark bulunamamıştır. Sonuç: RAS’li hastalarda TOS, TAS ve OSI değerleri oksidatif süreç lehine değişmektedirler. RAS patogenezinde oksidan maddeler ve antioksidan aktif maddeler önemlidir.

Anahtar Kelimeler

• Rekürren Aftöz Stomatit
• Total Oksidan Durum
• Total Antioksidan Durum
• Oksidatif Stres İndeksi

Evaluation of Total Oxidant Status, Antioxidant Status and Oxidative Stress Index in Patients with Recurrent Aphthous Stomatitis

Öz

Objective: We try to evaluate total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in patients with recurrent aphtous stomatitis (RAS) in our study. Methods: A total of 40 patients, 23 female and 17 male, with a mean age of 29, who applied to the dermatology outpatient clinic with the complaint of oral ulcers and were diagnosed with RAS and a total of 49 healthy controls, 33 female and 16 male, with a mean age of 24, were included in the study. Results: The TOS and OSI values of the RAS group were statistically significantly higher than the values of the control group. When the TAS values of both groups were compared; the TAS value of the RAS group was statistically indifferent from the TAS value of the control group. Conclusion: In patients with RAS, serum TOS, serum TAS and OSI values are affected in favour of oxidative processes. In the pathogenesis of RAS, oxidant substances and antioxidant-active substances are important.

Anahtar Kelimeler

• Recurrent Aphtous Stomatitis
• Total Oxidant Status
• Total Antioxidant Status
• Oxidative Stress Index

Kaynakça

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