MALIGNANT TRANSFORMATION OF MATURE CYSTIC TERATOMA OF THE OVARY: SQUAMOUS CELL CARCINOMA POSTMENOPAUSAL PATIENT

Öz

Ovarian tumors account for about %6 of female malignancies. %20 of ovarian tumors are germ cell ovarian malignancies and the commonest type of germ cell tumors of ovary is teratoma.1 Teratomas have subtypes like mature, immature and specialized tissue. Of all the germ cell tumors only mature cystic teratoma (MCT) is benign. However, MCT can under go malign transformation in less than %2 of cases. Malign transformation seen especially in postmenopausal patients. Most common type (%80) of malign transformation is squamous cell carcinoma.2 In this article we report a case of squamous cell carcinoma arising from ovarian MCT in a postmenopausal patient.

Anahtar Kelimeler

• Mature cystic teratoma
• ovarian tumour
• SCC
• imaging.

OVER MATÜR KİSTİK TERATOMDA MALİGN DÖNÜŞÜM: POSTMENOPOZAL HASTADA SKUAMÖZ HÜCRELİ KARSİNOM OLGU SUNUMU

Öz

Over tümörleri, kadın malignitelerinin yaklaşık %6'sını oluşturur. Over tümörlerinin %20'si germ hücreli malignitelerdir ve overin en sık görülen germ hücreli tümör tipi teratomdur.1 Teratomların matür, immatür ve özelleşmiş doku gibi alt tipleri vardır. Tüm germ hücreli tümörler arasında sadece matür kistik teratom (MCT) iyi huyludur. Ancak MCT, vakaların %2'sinden daha azında malign transformasyona uğrayabilir. Malign transformasyon özellikle postmenopozal hastalarda görülür. En sık görülen malign transformasyon tipi (%80) skuamöz hücreli karsinomdur.2 Bu makalede, postmenopozal bir hastada over MCT'sinden kaynaklanan skuamöz hücreli karsinom olgusunu bildiriyoruz.

Anahtar Kelimeler

• Matür kistik teratom
• Ovaryan tümör
• SCC
• Görüntüleme

Kaynakça

1. Bhurgri Y, Shaheen Y, Kayani N, et al. Incidence, trends and morphology of ovarian cancer in Karachi (1995-2002). Asian Pac J Cancer Prev. 2011;12(6):1567-1571.
2. Kido A, Togashi K, Konishi I, et al. Dermoid cysts of the ovary with malignant transformation: MR appearance. AJR Am J Roentgenol. 1999;172(2):445-449. doi:10.2214/ajr.172.2.9930800
3. Kikkawa F, Nawa A, Tamakoshi K, et al. Diagnosis of squamous cell carcinoma arising from mature cystic teratoma of the ovary. Cancer. 1998;82(11):2249-2255. doi:10.1002/(SICI)1097-0142(19980601)82:11<2249::AID-CNCR21>3.0.CO;2-T
4. Mori Y, Nishii H, Takabe K, et al. Preoperative diagnosis of malignant transformation arising from mature cystic teratoma of the ovary. Gynecol Oncol. 2003;90(2):338-341. doi:10.1016/S0090-8258(03)00259-2
5. Atwi D, Kamal M, Quinton M, Hassell LA. Malignant transformation of mature cystic teratoma of the ovary. J Obstet Gynaecol Res. 2022;48(12):3068-3076. doi:10.1111/jog.15409
6. Chiang AJ, Chen MY, Weng CS, et al. Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group study. J Gynecol Oncol. 2017;28(5). doi:10.3802/jgo.2017.28.e69
7. Gürel H, Gürel SA. Ovarian cystic teratoma with a pathognomonic appearance of multiple floating balls: a case report and investigation of common characteristics of the cases in the literature. Fertil Steril. 2008;90(5):2008.e17-2008.e29. doi:10.1016/j.fertnstert.2008.01.013
8. Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA. Cystic teratomas of the ovary: diagnostic value of sonography. AJR Am J Roentgenol. 1998;171(4):1061-1065. doi:10.2214/ajr.171.4.9762997

9. Wu SY, Giannini A, Girardo M, et al. Malignant transformation of squamous cell carcinoma in mature cystic teratoma of the ovary: a systematic review and meta-analysis of data. Gynecol Obstet Invest. 2025;90(3):255-267. doi:10.1159/000542672.